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KRT3 keratin 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_057088 Homo sapiens keratin 3 (KRT3), mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005268859 PREDICTED: Homo sapiens keratin 3 (KRT3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006719392 PREDICTED: Homo sapiens keratin 3 (KRT3), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006719393 PREDICTED: Homo sapiens keratin 3 (KRT3), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol KRT3
Entrez Gene ID 3850
Full Name keratin 3
Synonyms CK3, K3
General protein information
Preferred Names
keratin, type II cytoskeletal 3
Names
keratin, type II cytoskeletal 3
CK-3
cytokeratin 3
cytokeratin-3
65 kDa cytokeratin
type-II keratin Kb3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13.13

Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].
Disorder

MIM: 148043

Meesmann corneal dystrophy, 122100 (3)

mRNA Protein Product Sequence Price Select
NM_057088, 109148551 NP_476429, 109148552 keratin, type II cytoskeletal 3 ORF Sequence $700.00
XM_005268859, 530400220 XP_005268916, 530400221 keratin, type II cytoskeletal 3 isoform X1 ORF Sequence $700.00
XM_006719392, 578823705 XP_006719455, 578823706 keratin, type II cytoskeletal 3 isoform X2 ORF Sequence $700.00
XM_006719393, 578823707 XP_006719456, 578823708 keratin, type II cytoskeletal 3 isoform X3 ORF Sequence $700.00
Process
IDNameEvidence
GO:0030855epithelial cell differentiationISS
GO:0045104intermediate filament cytoskeleton organizationIMP
Component
IDNameEvidence
GO:0005882intermediate filamentNAS
GO:0045095keratin filamentTAS
Function
IDNameEvidence
GO:0005198structural molecule activityIMP
GeneCards KRT3
UniProt P12035
Vega OTTHUMG00000169799
MIM 148043
Ensembl ENSG00000186442
HGNC 6440
HPRD 01013

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the KRT3 gene?

The KRT3 gene provides instructions for making a protein called keratin 3. Keratins are a group of tough, fibrous proteins that form the structural framework of epithelial cells, which are cells that line the surfaces and cavities of the body. Keratin 3 is produced in a tissue on the surface of the eye called the corneal epithelium. This tissue forms the outermost layer of the cornea, which is the clear front covering of the eye. The corneal epithelium acts as a barrier to help prevent foreign materials, such as dust and bacteria, from entering the eye.

The keratin 3 protein partners with another keratin protein, keratin 12, to form molecules known as intermediate filaments. These filaments assemble into strong networks that provide strength and resilience to the corneal epithelium.

Interactant

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