Sequence in raw or FASTA format:
KRT6A keratin 6A [Homo sapiens (human)]
|Entrez Gene ID||3853|
|Full Name||keratin 6A|
|Synonyms||CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].|
Pachyonychia congenita, Jadassohn-Lewandowsky type, 167200 (3)
|Homo sapiens (human)||KRT6A||NP_005545.1|
|Pan troglodytes (chimpanzee)||KRT6A||XP_509078.2|
|Macaca mulatta (Rhesus monkey)||LOC100424162||XP_002798640.1|
|Canis lupus familiaris (dog)||KRT6B||XP_003433560.1|
|Canis lupus familiaris (dog)||KRT6A||XP_005636851.1|
|Bos taurus (cattle)||KRT6A||NP_001076979.1|
|Bos taurus (cattle)||KRT6B||NP_001244333.1|
|Bos taurus (cattle)||KRT6C||XP_002687296.1|
|Gallus gallus (chicken)||KRT3||XP_004949798.1|
|GO:0008284||positive regulation of cell proliferation||NAS|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0005200||structural constituent of cytoskeleton||NAS|
What is the normal function of the KRT6A gene?
The KRT6A gene provides instructions for making a protein called keratin 6a or K6a. Keratins are a group of tough, fibrous proteins that form the structural framework of certain cells, particularly cells that make up the skin, hair, nails, and similar tissues. Keratin 6a is produced in the nails, the skin on the palms of the hands and soles of the feet, and the oral mucosa that lines the inside of the mouth.
Keratin 6a partners with a similar protein, keratin 16, to form molecules called keratin intermediate filaments. These filaments assemble into dense networks that provide strength and resilience to the skin, nails, and other tissues. Networks of keratin filaments protect these tissues from being damaged by friction and other everyday physical stresses. Keratin 6a is also among several keratins involved in wound healing.
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