KRT10 keratin 10 [Homo sapiens (human)]
| Gene Symbol | KRT10 |
| Entrez Gene ID | 3858 |
| Full Name | keratin 10 |
| Synonyms | BCIE, BIE, CK10, EHK, K10, KPP |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17q21 |
| Summary | This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq]. |
| Disorder | MIM: 148080 Epidermolytic hyperkeratosis, 113800 (3); Ichthyosis, cyclic, with |
| mRNA | NM_000421, 195972865 |
| Protein | NP_000412, 195972866 |
| Product | keratin, type I cytoskeletal 10 |
| RefSeq Status | REVIEWED |
| hsa05150 | Staphylococcus aureus infection |
| Homo sapiens (human) | KRT10 | NP_000412.3 |
| Pan troglodytes (chimpanzee) | KRT10 | XP_001169499.1 |
| Canis lupus familiaris (dog) | KRT10 | NP_001013443.1 |
| Bos taurus (cattle) | LOC100138974 | XP_001788780.1 |
| Bos taurus (cattle) | KRT10 | NP_776802.1 |
| Mus musculus (house mouse) | Krt10 | NP_034790.2 |
| Rattus norvegicus (Norway rat) | Krt10 | NP_001008804.1 |
| Gallus gallus (chicken) | KRT10 | XP_001235182.1 |
| Gallus gallus (chicken) | KRT10 | XP_418163.2 |
| ID | Name | Evidence |
| GO:0008544 | epidermis development | TAS |
| GO:0030855 | epithelial cell differentiation | IEA |
| GO:0071277 | cellular response to calcium ion | IEA |
Component
| ID | Name | Evidence |
| GO:0005882 | intermediate filament | NAS |
| GO:0045095 | keratin filament | IEA |
Function
| ID | Name | Evidence |
| GO:0005198 | structural molecule activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0030280 | structural constituent of epidermis | NAS |
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