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KRT10 keratin 10 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000421 Homo sapiens keratin 10 (KRT10), mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005257343 PREDICTED: Homo sapiens keratin 10 (KRT10), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol KRT10
Entrez Gene ID 3858
Full Name keratin 10
Synonyms BCIE, BIE, CK10, EHK, K10, KPP
General protein information
Preferred Names
keratin, type I cytoskeletal 10
Names
keratin, type I cytoskeletal 10
CK-10
keratin-10
cytokeratin 10
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21

Summary This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008].
Disorder

MIM: 148080

Epidermolytic hyperkeratosis, 113800 (3); Ichthyosis, cyclic, with

mRNA Protein Product Sequence Price Select
NM_000421, 195972865 NP_000412, 195972866 keratin, type I cytoskeletal 10 ORF Sequence $700.00
XM_005257343, 530412175 XP_005257400, 530412176 keratin, type I cytoskeletal 10 isoform X1 ORF Sequence $700.00
KEGG
hsa05150Staphylococcus aureus infection
Process
IDNameEvidence
GO:0030216keratinocyte differentiationIEP
GO:0071277cellular response to calcium ionIEA
Component
IDNameEvidence
GO:0005615extracellular spaceIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005882intermediate filamentNAS
GO:0016020membraneIDA
GO:0045095keratin filamentIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0030280structural constituent of epidermisNAS
GeneCards KRT10
PDB 4F1Z, 3ASW
UniProt P13645
Vega OTTHUMG00000133368
MIM 148080
Ensembl ENSG00000186395
HGNC 6413
HPRD 01021

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the KRT10 gene?

The KRT10 gene provides instructions for making a protein called keratin 10. Keratins are a group of tough, fibrous proteins that form the structural framework of cells called keratinocytes that make up the skin, hair, and nails. Keratin 10 is produced in keratinocytes in the outer layer of the skin (the epidermis).

In the fluid-filled space inside these cells (the cytoplasm), the keratin 10 protein partners with a similar protein, keratin 1 (produced from the KRT1 gene), to form molecules called keratin intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the skin and protect it from being damaged by friction and other everyday physical stresses.

Interactant

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