Sequence in raw or FASTA format:
KRT10 keratin 10 [Homo sapiens (human)]
|Entrez Gene ID||3858|
|Full Name||keratin 10|
|Synonyms||BCIE, BIE, CK10, EHK, K10, KPP|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008].|
Epidermolytic hyperkeratosis, 113800 (3); Ichthyosis, cyclic, with
|hsa05150||Staphylococcus aureus infection|
|GO:0071277||cellular response to calcium ion||IEA|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0030280||structural constituent of epidermis||NAS|
What is the normal function of the KRT10 gene?
The KRT10 gene provides instructions for making a protein called keratin 10. Keratins are a group of tough, fibrous proteins that form the structural framework of cells called keratinocytes that make up the skin, hair, and nails. Keratin 10 is produced in keratinocytes in the outer layer of the skin (the epidermis).
In the fluid-filled space inside these cells (the cytoplasm), the keratin 10 protein partners with a similar protein, keratin 1 (produced from the KRT1 gene), to form molecules called keratin intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the skin and protect it from being damaged by friction and other everyday physical stresses.
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