Sequence in raw or FASTA format:
KRT12 keratin 12 [Homo sapiens (human)]
|Entrez Gene ID||3859|
|Full Name||keratin 12|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008].|
Meesmann corneal dystrophy, 122100 (3)
|Homo sapiens (human)||KRT12||NP_000214.1|
|Pan troglodytes (chimpanzee)||KRT12||XP_001168468.1|
|Macaca mulatta (Rhesus monkey)||KRT12||XP_001101582.1|
|Canis lupus familiaris (dog)||KRT12||NP_001075890.1|
|Bos taurus (cattle)||KRT12||XP_002696056.2|
|Mus musculus (house mouse)||Krt12||NP_034791.2|
|Rattus norvegicus (Norway rat)||Krt12||NP_001008761.1|
|Gallus gallus (chicken)||KRT12||XP_004948663.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||LOC100486967||XP_002940696.1|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0005198||structural molecule activity||IEA|
What is the normal function of the KRT12 gene?
The KRT12 gene provides instructions for making a protein called keratin 12. Keratins are a group of tough, fibrous proteins that form the structural framework of epithelial cells, which are cells that line the surfaces and cavities of the body. Keratin 12 is produced in a tissue on the surface of the eye called the corneal epithelium. This tissue forms the outermost layer of the cornea, which is the clear front covering of the eye. The corneal epithelium acts as a barrier to help prevent foreign materials, such as dust and bacteria, from entering the eye.
The keratin 12 protein partners with another keratin protein, keratin 3, to form molecules known as intermediate filaments. These filaments assemble into strong networks that provide strength and resilience to the corneal epithelium.
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