• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


KRT12 keratin 12 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000223 Homo sapiens keratin 12 (KRT12), mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol KRT12
Entrez Gene ID 3859
Full Name keratin 12
Synonyms K12
General protein information
Preferred Names
keratin, type I cytoskeletal 12
keratin, type I cytoskeletal 12
Gene Type protein-coding
Organism Homo sapiens (human)



Summary KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008].

MIM: 601687

Meesmann corneal dystrophy, 122100 (3)

mRNA Protein Product Sequence Price Select
NM_000223, 156602658 NP_000214, 4557699 keratin, type I cytoskeletal 12 ORF Sequence $550.00
Homo sapiens (human)KRT12NP_000214.1
Pan troglodytes (chimpanzee)KRT12XP_001168468.1
Macaca mulatta (Rhesus monkey)KRT12XP_001101582.1
Canis lupus familiaris (dog)KRT12NP_001075890.1
Bos taurus (cattle)KRT12XP_002696056.2
Mus musculus (house mouse)Krt12NP_034791.2
Rattus norvegicus (Norway rat)Krt12NP_001008761.1
Gallus gallus (chicken)KRT12XP_004948663.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100486967XP_002940696.1
GO:0007601visual perceptionTAS
GO:0005882intermediate filamentIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0005198structural molecule activityIEA
GeneCards KRT12
UniProt Q99456
Vega OTTHUMG00000133369
MIM 601687
Ensembl ENSG00000187242
HGNC 6414
HPRD 03405

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the KRT12 gene?

The KRT12 gene provides instructions for making a protein called keratin 12. Keratins are a group of tough, fibrous proteins that form the structural framework of epithelial cells, which are cells that line the surfaces and cavities of the body. Keratin 12 is produced in a tissue on the surface of the eye called the corneal epithelium. This tissue forms the outermost layer of the cornea, which is the clear front covering of the eye. The corneal epithelium acts as a barrier to help prevent foreign materials, such as dust and bacteria, from entering the eye.

The keratin 12 protein partners with another keratin protein, keratin 3, to form molecules known as intermediate filaments. These filaments assemble into strong networks that provide strength and resilience to the corneal epithelium.


Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.