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KRT18 keratin 18 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000224 Homo sapiens keratin 18 (KRT18), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_199187 Homo sapiens keratin 18 (KRT18), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol KRT18
Entrez Gene ID 3875
Full Name keratin 18
Synonyms CYK18, K18
General protein information
Preferred Names
keratin, type I cytoskeletal 18
Names
keratin, type I cytoskeletal 18
CK-18
keratin-18
cytokeratin 18
cytokeratin-18
cell proliferation-inducing protein 46
cell proliferation-inducing gene 46 protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13

Summary KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 148070

Cirrhosis, cryptogenic (3); {Cirrhosis, noncryptogenic,

mRNA Protein Product Sequence Price Select
NM_000224, 40354193 NP_000215, 4557888 keratin, type I cytoskeletal 18 ORF Sequence $360.00
NM_199187, 40354194 NP_954657, 40354195 keratin, type I cytoskeletal 18 ORF Sequence $360.00
KEGG
hsa05130Pathogenic Escherichia coli infection
WikiPathways
WP437EGFR1 Signaling Pathway
WP2272Pathogenic Escherichia coli infection
Pathway Interaction Database
caspase_pathwayCaspase cascade in apoptosis
Homo sapiens (human)KRT18NP_954657.1
Pan troglodytes (chimpanzee)KRT18XP_509083.2
Macaca mulatta (Rhesus monkey)LOC695989XP_002808189.1
Canis lupus familiaris (dog)KRT18XP_534794.1
Bos taurus (cattle)KRT18NP_001179024.1
Mus musculus (house mouse)Krt18NP_034794.2
Rattus norvegicus (Norway rat)Krt18NP_446428.1
Danio rerio (zebrafish)krt18NP_848524.1
Danio rerio (zebrafish)zgc:77517NP_956862.1
Xenopus (Silurana) tropicalis (western clawed frog)krt18NP_988944.1
Process
IDNameEvidence
GO:0007049cell cycleIEA
GO:0009653anatomical structure morphogenesisTAS
GO:0016032viral processIEA
GO:0033209tumor necrosis factor-mediated signaling pathwayIEA
GO:0043000Golgi to plasma membrane CFTR protein transportIDA
GO:0043066negative regulation of apoptotic processIDA
GO:0045104intermediate filament cytoskeleton organizationIDA
GO:0097191extrinsic apoptotic signaling pathwayIEA
GO:0097284hepatocyte apoptotic processIEA
Component
IDNameEvidence
GO:0005730nucleolusIEA
GO:0005737cytoplasmIDA
GO:0005815microtubule organizing centerIDA
GO:0005882intermediate filamentIDA
GO:0034451centriolar satelliteIDA
GO:0045095keratin filamentIDA
GO:0048471perinuclear region of cytoplasmIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005198structural molecule activityIEA
GO:0005515protein bindingIPI
GO:0044822poly(A) RNA bindingIDA
GO:0097110scaffold protein bindingIPI
GeneCards KRT18
UniProt P05783
Vega OTTHUMG00000169882
MIM 148070
Ensembl ENSG00000111057
HGNC 6430
HPRD 01020

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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