Sequence in raw or FASTA format:
KRT83 keratin 83 [Homo sapiens (human)]
|Entrez Gene ID||3889|
|Full Name||keratin 83|
|Synonyms||HB3, Hb-3, KRTHB3|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008].|
Monilethrix, 158000 (3)
|Homo sapiens (human)||KRT83||NP_002273.3|
|Pan troglodytes (chimpanzee)||KRT83||XP_003313733.1|
|Macaca mulatta (Rhesus monkey)||KRT83||XP_001093322.1|
|Bos taurus (cattle)||KRT83||NP_001076854.1|
|Mus musculus (house mouse)||5430421N21Rik||NP_001188252.1|
|Rattus norvegicus (Norway rat)||Kb23||NP_001008813.1|
|GO:0005198||structural molecule activity||IEA|
What is the normal function of the KRT83 gene?
The KRT83 gene provides instructions for making the type II hair keratin K83 protein (K83). This protein belongs to a group of proteins known as keratins, which are tough, fibrous proteins that form the structural framework of cells that make up the hair, skin, and nails. Each keratin protein partners with another keratin protein to form molecules called intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the tissues and protect them from being damaged by everyday physical stresses. The K83 protein is found in cells that make up the inner compartment of the hair shaft known as the cortex, and this protein helps give hair its strength and elasticity.
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