KRT86 keratin 86 [Homo sapiens (human)]
| Gene Symbol | KRT86 |
| Entrez Gene ID | 3892 |
| Full Name | keratin 86 |
| Synonyms | FLJ25176, HB6, Hb1, KRTHB1, KRTHB6, MNX, hHb6 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
12 12q13 |
| Summary | The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq]. |
| Disorder | MIM: 601928 Monilethrix, 158000 (3) |
| mRNA | NM_002284, 109637786 |
| Protein | NP_002275, 14318422 |
| Product | keratin, type II cuticular Hb6 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | KRT86 | NP_002275.1 |
| Pan troglodytes (chimpanzee) | KRT86 | XP_522385.2 |
| Canis lupus familiaris (dog) | KRT86 | XP_543656.2 |
| Bos taurus (cattle) | KRT86 | XP_872158.2 |
| Mus musculus (house mouse) | Krt86 | NP_034797.1 |
| Rattus norvegicus (Norway rat) | Krt86 | NP_001008810.1 |
| ID | Name | Evidence |
| GO:0007010 | cytoskeleton organization | NAS |
Component
| ID | Name | Evidence |
| GO:0005882 | intermediate filament | NAS |
| GO:0045095 | keratin filament | IEA |
Function
| ID | Name | Evidence |
| GO:0005198 | structural molecule activity | NAS |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |