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KRT86 keratin 86 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002284 Homo sapiens keratin 86 (KRT86), mRNA. ORF Sequence $423.69
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Gene Symbol KRT86
Entrez Gene ID 3892
Full Name keratin 86
Synonyms FLJ25176, HB6, Hb1, KRTHB1, KRTHB6, MNX, hHb6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13

Summary The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601928

Monilethrix, 158000 (3)

mRNA Protein Product Sequence Price Select
NM_002284, 109637786 NP_002275, 14318422 keratin, type II cuticular Hb6 Full Length $606.39
ORF Sequence $423.69
Homo sapiens (human)KRT86NP_002275.1
Pan troglodytes (chimpanzee)KRT86XP_003313734.1
Macaca mulatta (Rhesus monkey)LOC697511XP_001086087.1
Canis lupus familiaris (dog)KRT86XP_543656.2
Bos taurus (cattle)KRT86NP_001179997.1
Mus musculus (house mouse)Krt86NP_034797.1
Rattus norvegicus (Norway rat)Krt86NP_001008810.1
GeneCards KRT86
UniProt O43790
MIM 601928
Ensembl ENSG00000170442
HGNC 6463
HPRD 03567

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
keratin, type II cuticular Hb6
Names
keratin, type II cuticular Hb6
K86
keratin-86
hair keratin K2.11
keratin protein HB6
type-II keratin Kb26
hard keratin, type II, 6
type II hair keratin Hb6
keratin, hair, basic, 6 (monilethrix)

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