Sequence in raw or FASTA format:
KRT86 keratin 86 [Homo sapiens (human)]
|Entrez Gene ID||3892|
|Full Name||keratin 86|
|Synonyms||HB6, Hb1, KRTHB1, KRTHB6, MNX, hHb6|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008].|
Monilethrix, 158000 (3)
|Homo sapiens (human)||KRT86||NP_002275.1|
|Pan troglodytes (chimpanzee)||KRT86||XP_522385.2|
|Canis lupus familiaris (dog)||KRT86||XP_543656.2|
|Bos taurus (cattle)||KRT86||NP_001179997.1|
|Mus musculus (house mouse)||Krt86||NP_034797.1|
|Rattus norvegicus (Norway rat)||Krt86||NP_001008810.1|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0005198||structural molecule activity||IEA|
What is the normal function of the KRT86 gene?
The KRT86 gene provides instructions for making the type II hair keratin K86 protein (K86). This protein belongs to a group of proteins known as keratins, which are tough, fibrous proteins that form the structural framework of cells that make up the hair, skin, and nails. Each keratin protein partners with another keratin protein to form molecules called intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the tissues and protect them from being damaged by everyday physical stresses. The K86 protein is found in cells that make up the inner compartment of the hair shaft known as the cortex, and this protein helps give hair its strength and elasticity.
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