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KRT86 keratin 86 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002284 Homo sapiens keratin 86 (KRT86), mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005268866 PREDICTED: Homo sapiens keratin 86 (KRT86), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Related Services

Gene Symbol KRT86
Entrez Gene ID 3892
Full Name keratin 86
Synonyms HB6, Hb1, KRTHB1, KRTHB6, MNX, hHb6
General protein information
Preferred Names
keratin, type II cuticular Hb6
Names
keratin, type II cuticular Hb6
K86
keratin-86
hair keratin K2.11
keratin protein HB6
type-II keratin Kb26
hard keratin, type II, 6
type II hair keratin Hb6
keratin, hair, basic, 6 (monilethrix)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13

Summary The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601928

Monilethrix, 158000 (3)

mRNA Protein Product Sequence Price Select
NM_002284, 109637786 NP_002275, 14318422 keratin, type II cuticular Hb6 ORF Sequence $550.00
XM_005268866, 578823713 XP_005268923, 530400236 keratin, type II cuticular Hb6 isoform X1 ORF Sequence $550.00
Homo sapiens (human)KRT86NP_002275.1
Pan troglodytes (chimpanzee)KRT86XP_522385.2
Canis lupus familiaris (dog)KRT86XP_543656.2
Bos taurus (cattle)KRT86NP_001179997.1
Mus musculus (house mouse)Krt86NP_034797.1
Rattus norvegicus (Norway rat)Krt86NP_001008810.1
Component
IDNameEvidence
GO:0005615extracellular spaceIDA
GO:0045095keratin filamentIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005198structural molecule activityIEA
GeneCards KRT86
UniProt O43790
Vega OTTHUMG00000184153
MIM 601928
Ensembl ENSG00000170442
HGNC 6463
HPRD 03567

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the KRT86 gene?

The KRT86 gene provides instructions for making the type II hair keratin K86 protein (K86). This protein belongs to a group of proteins known as keratins, which are tough, fibrous proteins that form the structural framework of cells that make up the hair, skin, and nails. Each keratin protein partners with another keratin protein to form molecules called intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the tissues and protect them from being damaged by everyday physical stresses. The K86 protein is found in cells that make up the inner compartment of the hair shaft known as the cortex, and this protein helps give hair its strength and elasticity.

Interactant

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