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LAMA2 laminin, alpha 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000426 Homo sapiens laminin, alpha 2 (LAMA2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_001079823 Homo sapiens laminin, alpha 2 (LAMA2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $4749.00 40

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Gene Symbol LAMA2
Entrez Gene ID 3908
Full Name laminin, alpha 2
Synonyms LAMM
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q22-q23

Summary Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 156225

Muscular dystrophy, congenital merosin-deficient, 607855 (3);

mRNA Protein Product Sequence Price Select
NM_000426, 119466530 NP_000417, 28559088 laminin subunit alpha-2 isoform a precursor ORF Sequence $4500.00
NM_001079823, 119466531 NP_001073291, 119466532 laminin subunit alpha-2 isoform b precursor ORF Sequence $4500.00
KEGG
hsa05414Dilated cardiomyopathy
hsa04151PI3K-Akt signaling pathway
hsa05200Pathways in cancer
hsa05145Toxoplasmosis
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05416Viral myocarditis
hsa04512ECM-receptor interaction
hsa05222Small cell lung cancer
hsa05146Amoebiasis
hsa04510Focal adhesion
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
WikiPathways
WP306Focal Adhesion
WP2118Arrhythmogenic right ventricular cardiomyopathy
WP244Alpha6-Beta4 Integrin Signaling Pathway
Reactome
REACT_111102Signal Transduction
REACT_13552Integrin cell surface interactions
Homo sapiens (human)LAMA2NP_000417.2
Pan troglodytes (chimpanzee)LAMA2XP_527501.2
Macaca mulatta (Rhesus monkey)LAMA2XP_001105600.2
Canis lupus familiaris (dog)LAMA2XP_003432570.1
Bos taurus (cattle)LAMA2XP_002690266.1
Mus musculus (house mouse)Lama2NP_032507.2
Rattus norvegicus (Norway rat)Lama2XP_219866.5
Gallus gallus (chicken)LAMA2XP_419746.3
Caenorhabditis eleganslam-3NP_492775.2
GeneCards LAMA2
UniProt Q59H37, P24043
MIM 156225
Ensembl ENSG00000196569
HGNC 6482
HPRD 01125

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
laminin subunit alpha-2
Names
laminin subunit alpha-2
laminin M chain
merosin heavy chain
laminin-2 subunit alpha
laminin-4 subunit alpha
laminin-12 subunit alpha

Interactant



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