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LAMA2 laminin, alpha 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000426 Homo sapiens laminin, alpha 2 (LAMA2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_001079823 Homo sapiens laminin, alpha 2 (LAMA2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_005266981 PREDICTED: Homo sapiens laminin, alpha 2 (LAMA2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_005266982 PREDICTED: Homo sapiens laminin, alpha 2 (LAMA2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $4749.00 40

*Business Day

Related Services

Gene Symbol LAMA2
Entrez Gene ID 3908
Full Name laminin, alpha 2
Synonyms LAMM
General protein information
Preferred Names
laminin subunit alpha-2
Names
laminin subunit alpha-2
laminin M chain
merosin heavy chain
laminin-2 subunit alpha
laminin-4 subunit alpha
laminin-12 subunit alpha
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q22-q23

Summary Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 156225

Muscular dystrophy, congenital merosin-deficient, 607855 (3);

mRNA Protein Product Sequence Price Select
NM_000426, 119466530 NP_000417, 28559088 laminin subunit alpha-2 isoform a precursor ORF Sequence $4500.00
NM_001079823, 119466531 NP_001073291, 119466532 laminin subunit alpha-2 isoform b precursor ORF Sequence $4500.00
XM_005266981, 530383699 XP_005267038, 530383700 laminin subunit alpha-2 isoform X1 ORF Sequence $4500.00
XM_005266982, 530383701 XP_005267039, 530383702 laminin subunit alpha-2 isoform X2 ORF Sequence $4500.00
KEGG
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05416Viral myocarditis
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa04151PI3K-Akt signaling pathway
WikiPathways
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP2118Arrhythmogenic right ventricular cardiomyopathy
Reactome
REACT_118779Extracellular matrix organization
REACT_163906ECM proteoglycans
REACT_163874Non-integrin membrane-ECM interactions
REACT_169262Laminin interactions
Homo sapiens (human)LAMA2NP_001073291.1
Pan troglodytes (chimpanzee)LAMA2XP_003311525.1
Macaca mulatta (Rhesus monkey)LAMA2XP_001105600.2
Canis lupus familiaris (dog)LAMA2XP_003432570.1
Bos taurus (cattle)LAMA2XP_002690266.1
Mus musculus (house mouse)Lama2NP_032507.2
Rattus norvegicus (Norway rat)Lama2XP_219866.6
Gallus gallus (chicken)LAMA2XP_419746.4
Danio rerio (zebrafish)lama2NP_001265728.1
Caenorhabditis eleganslam-3NP_492775.2
Xenopus (Silurana) tropicalis (western clawed frog)lama2XP_002936356.2
Process
IDNameEvidence
GO:0007155cell adhesionIEA
GO:0007411axon guidanceIEA
GO:0007517muscle organ developmentTAS
GO:0022011myelination in peripheral nervous systemIEA
GO:0030155regulation of cell adhesionIEA
GO:0030198extracellular matrix organizationTAS
GO:0030334regulation of cell migrationIEA
GO:0032224positive regulation of synaptic transmission, cholinergicIEA
GO:0045995regulation of embryonic developmentIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005604basement membraneIDA
GO:0005606laminin-1 complexIEA
GO:0031012extracellular matrixISS
GO:0042383sarcolemmaIEA
GO:0043197dendritic spineIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005102receptor bindingIEA
GO:0005198structural molecule activityTAS
GeneCards LAMA2
UniProt Q59H37, P24043
Vega OTTHUMG00000015545
MIM 156225
Ensembl ENSG00000196569
HGNC 6482
HPRD 01125

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LAMA2 gene?

The LAMA2 gene provides instructions for making a part (subunit) of certain members of a protein family called laminins. Laminin proteins are made of three different subunits called alpha, beta, and gamma. There are several forms of each subunit, and each form is produced from instructions carried by a different gene. The LAMA2 gene provides instructions for the alpha-2 subunit. This subunit, together with the beta-1 and gamma-1 subunits, forms the laminin 2 protein, also known as merosin or laminin-211. The alpha-2 subunit, along with the beta-2 and gamma-1 subunits, also forms another laminin called laminin 4, sometimes known as laminin-221.

Laminins are found in an intricate lattice of proteins and other molecules that forms in the spaces between cells (the extracellular matrix). There, the laminins help regulate cell growth, cell movement (motility), and the attachment of cells to one another (adhesion). They are also involved in the formation and organization of basement membranes, which are thin, sheet-like structures within the extracellular matrix that separate and support cells in many tissues. Laminin 2 and laminin 4 play a particularly important role in the muscles used for movement (skeletal muscles). The laminins attach (bind) to other proteins in the extracellular matrix and in the membrane of muscle cells, which helps maintain the stability of muscle fibers.

Interactant

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