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LAMA3 laminin, alpha 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000227 Homo sapiens laminin, alpha 3 (LAMA3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
NM_001127717 Homo sapiens laminin, alpha 3 (LAMA3), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_001127718 Homo sapiens laminin, alpha 3 (LAMA3), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
NM_198129 Homo sapiens laminin, alpha 3 (LAMA3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol LAMA3
Entrez Gene ID 3909
Full Name laminin, alpha 3
Synonyms BM600, E170, LAMNA, LOCS, lama3a
General protein information
Preferred Names
laminin subunit alpha-3
Names
laminin subunit alpha-3
BM600 150kD subunit
nicein 150kD subunit
nicein subunit alpha
kalinin 165kD subunit
kalinin subunit alpha
epiligrin subunit alpha
laminin-5 alpha 3 chain
laminin-5 subunit alpha
laminin-6 subunit alpha
laminin-7 subunit alpha
epiligrin 170 kda subunit
epiligrin alpha 3 subunit
laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18q11.2

Summary Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600805

Epidermolysis bullosa, junctional, Herlitz type, 226700 (3);

mRNA Protein Product Sequence Price Select
NM_000227, 189217423 NP_000218, 38045908 laminin subunit alpha-3 isoform 2 precursor ORF Sequence $2500.00
NM_001127717, 189217424 NP_001121189, 189217425 laminin subunit alpha-3 isoform 3 precursor ORF Sequence $4500.00
NM_001127718, 189217427 NP_001121190, 189217428 laminin subunit alpha-3 isoform 4 precursor ORF Sequence $2500.00
NM_198129, 38045909 NP_937762, 38045910 laminin subunit alpha-3 isoform 1 precursor ORF Sequence $-1.00
KEGG
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa04151PI3K-Akt signaling pathway
WikiPathways
WP244Alpha6-Beta4 Integrin Signaling Pathway
Pathway Interaction Database
syndecan_2_pathwaySyndecan-2-mediated signaling events
syndecan_4_pathwaySyndecan-4-mediated signaling events
fra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
Reactome
REACT_20537Type I hemidesmosome assembly
REACT_20676Cell junction organization
REACT_111155Cell-Cell communication
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_120729Collagen formation
REACT_163906ECM proteoglycans
REACT_163874Non-integrin membrane-ECM interactions
REACT_150180Assembly of collagen fibrils and other multimeric structures
REACT_150268Anchoring fibril formation
REACT_169262Laminin interactions
Homo sapiens (human)LAMA3NP_937762.1
Pan troglodytes (chimpanzee)LAMA3XP_001156417.2
Macaca mulatta (Rhesus monkey)LAMA3XP_001095558.2
Canis lupus familiaris (dog)LAMA3XP_003435052.1
Bos taurus (cattle)LAMA3XP_003587818.2
Mus musculus (house mouse)Lama3NP_034810.1
Rattus norvegicus (Norway rat)Lama3XP_006254490.1
Gallus gallus (chicken)LAMA3XP_004939845.1
Xenopus (Silurana) tropicalis (western clawed frog)lama3XP_002934184.2
Process
IDNameEvidence
GO:0007155cell adhesionIEA
GO:0008544epidermis developmentTAS
GO:0022617extracellular matrix disassemblyTAS
GO:0030155regulation of cell adhesionIEA
GO:0030198extracellular matrix organizationTAS
GO:0030334regulation of cell migrationIEA
GO:0031581hemidesmosome assemblyTAS
GO:0034329cell junction assemblyTAS
GO:0045995regulation of embryonic developmentIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005604basement membraneTAS
GO:0005606laminin-1 complexIEA
GO:0005610laminin-5 complexIEA
Function
IDNameEvidence
GO:0005102receptor bindingIEA
GO:0005198structural molecule activityNAS
GeneCards LAMA3
UniProt Q16787
Vega OTTHUMG00000131874
MIM 600805
Ensembl ENSG00000053747
HGNC 6483
HPRD 02883

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LAMA3 gene?

The LAMA3 gene provides instructions for making one part (subunit) of a protein called laminin 332 (formerly known as laminin 5). This protein is made up of three subunits, called alpha, beta, and gamma. The LAMA3 gene carries instructions for the alpha subunit; the beta and gamma subunits are produced from other genes.

Laminins are a group of proteins that regulate cell growth, cell movement (motility), and the attachment of cells to one another (adhesion). They are also involved in the formation and organization of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Laminin 332 has a particularly important role in the basement membrane that underlies the top layer of skin (the epidermis). This membrane gives strength and resiliency to the skin and creates an additional barrier between the body and its surrounding environment. Laminin 332 is a major component of fibers called anchoring filaments, which connect the two layers of the basement membrane and help hold the skin together.

Studies suggest that laminin 332 also has several other functions. This protein appears to be important for wound healing. Additionally, researchers have proposed roles for laminin 332 in the clear outer covering of the eye (the cornea) and in the development of tooth enamel.

Interactant

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