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LAMA5 laminin, alpha 5 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_005560 Homo sapiens laminin, alpha 5 (LAMA5), mRNA. Full Length Quote
ORF Sequence Quote


Gene Symbol LAMA5
Entrez Gene ID 3911
Full Name laminin, alpha 5
Synonyms KIAA1907
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q13.2-q13.3
Summary Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq].
Disorder

MIM: 601033
mRNA NM_005560, 21264601
Protein NP_005551, 21264602
Product laminin subunit alpha-5 precursor
RefSeq Status REVIEWED
KEGG
hsa05222Small cell lung cancer
hsa04512ECM-receptor interaction
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa04510Focal adhesion
hsa05200Pathways in cancer
WikiPathways
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP306Focal Adhesion
WP453Inflammatory Response Pathway
Pathway Interaction Database
syndecan_1_pathwaySyndecan-1-mediated signaling events
Reactome
REACT_13552Integrin cell surface interactions
Homo sapiens (human)LAMA5NP_005551.3
Canis lupus familiaris (dog)LAMA5XP_855195.1
Bos taurus (cattle)LAMA5XP_583244.3
Mus musculus (house mouse)Lama5NP_001074640.1
Rattus norvegicus (Norway rat)Lama5XP_215963.4
Danio rerio (zebrafish)lama5NP_001034260.1
Drosophila melanogaster (fruit fly)LanANP_476617.1
Caenorhabditis elegansepi-1NP_001023282.1
Process
IDNameEvidence
GO:0001525angiogenesisNAS
GO:0001658branching involved in ureteric bud morphogenesisIEA
GO:0001738morphogenesis of a polarized epitheliumIEA
GO:0001755neural crest cell migrationIEA
GO:0001942hair follicle developmentIEA
GO:0007010cytoskeleton organizationNAS
GO:0007229integrin-mediated signaling pathwayIMP
GO:0007517muscle organ developmentIEA
GO:0008037cell recognitionNAS
GO:0008283cell proliferationNAS
GO:0009790embryo developmentNAS
GO:0009887organ morphogenesisIEA
GO:0016331morphogenesis of embryonic epitheliumIEA
GO:0016477cell migrationIDA
GO:0030154cell differentiationNAS
GO:0030155regulation of cell adhesionIEA
GO:0030324lung developmentIEA
GO:0030334regulation of cell migrationIEA
GO:0034446substrate adhesion-dependent cell spreadingIDA
GO:0042127regulation of cell proliferationIEA
GO:0042384cilium assemblyIEA
GO:0042475odontogenesis of dentine-containing toothIEA
GO:0045446endothelial cell differentiationNAS
GO:0045995regulation of embryonic developmentIEA
GO:0048041focal adhesion assemblyNAS
GO:0060445branching involved in salivary gland morphogenesisIEA
GO:0090002establishment of protein localization in plasma membraneIEA
Component
IDNameEvidence
GO:0005576extracellular regionEXP
GO:0005604basement membraneIDA
GO:0005605basal laminaNAS
GO:0005606laminin-1 complexIEA
GO:0005615extracellular spaceIDA
GO:0031012extracellular matrixIDA
GO:0043259laminin-10 complexIDA
GO:0043259laminin-10 complexTAS
GO:0043260laminin-11 complexTAS
Function
IDNameEvidence
GO:0005178integrin bindingIDA
GO:0005198structural molecule activityIC
GO:0005488bindingIEA
GeneCards LAMA5
UniProt O15230
MIM 601033
Ensembl ENSG00000130702
HGNC 6485
HPRD 03020

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