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LAMB1 laminin, beta 1 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_002291 Homo sapiens laminin, beta 1 (LAMB1), mRNA. Full Length $2639.70
ORF Sequence $2412.45


Gene Symbol LAMB1
Entrez Gene ID 3912
Full Name laminin, beta 1
Synonyms CLM, MGC142015
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q22
Summary Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq].
Disorder

MIM: 150240

?Cutis laxa, marfanoid neonatal type (1)
mRNA NM_002291, 167614503
Protein NP_002282, 167614504
Product laminin subunit beta-1 precursor
RefSeq Status REVIEWED
KEGG
hsa05146Amoebiasis
hsa04510Focal adhesion
hsa05222Small cell lung cancer
hsa05145Toxoplasmosis
hsa04512ECM-receptor interaction
hsa05200Pathways in cancer
WikiPathways
WP306Focal Adhesion
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP453Inflammatory Response Pathway
Reactome
REACT_18266Axon guidance
REACT_22205L1CAM interactions
REACT_13552Integrin cell surface interactions
Homo sapiens (human)LAMB1NP_002282.2
Pan troglodytes (chimpanzee)LAMB1XP_001165667.1
Canis lupus familiaris (dog)LAMB1XP_533089.2
Mus musculus (house mouse)Lamb1NP_032508.2
Rattus norvegicus (Norway rat)Lamb1XP_216679.4
Gallus gallus (chicken)LAMB1XP_415943.2
Danio rerio (zebrafish)lamb1aNP_775382.1
Process
IDNameEvidence
GO:0007155cell adhesionTAS
GO:0007411axon guidanceTAS
GO:0030335positive regulation of cell migrationIDA
GO:0031175neuron projection developmentIDA
GO:0034446substrate adhesion-dependent cell spreadingIDA
GO:0042476odontogenesisIDA
GO:0050679positive regulation of epithelial cell proliferationTAS
Component
IDNameEvidence
GO:0005576extracellular regionEXP
GO:0005576extracellular regionTAS
GO:0005604basement membraneIDA
GO:0005604basement membraneTAS
GO:0005606laminin-1 complexIDA
GO:0005606laminin-1 complexIPI
GO:0005606laminin-1 complexTAS
GO:0005607laminin-2 complexIDA
GO:0005607laminin-2 complexTAS
GO:0005615extracellular spaceIDA
GO:0043257laminin-8 complexIDA
GO:0043257laminin-8 complexTAS
GO:0043259laminin-10 complexIDA
GO:0048471perinuclear region of cytoplasmISS
Function
IDNameEvidence
GO:0005198structural molecule activityNAS
GO:0005201extracellular matrix structural constituentIDA
GeneCards LAMB1
UniProt Q8TAS6, P07942
MIM 150240
Ensembl ENSG00000091136
HGNC 6486
HPRD 01029

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