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LAMB2 laminin, beta 2 (laminin S) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17891 NM_002292 Homo sapiens laminin, beta 2 (laminin S) (LAMB2), mRNA. pcDNA3.1+-DYK On-demand 30 $2699.00
OHu17891 XM_005265127 PREDICTED: Homo sapiens laminin, beta 2 (laminin S) (LAMB2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 30 $2699.00
OHu17891C NM_002292 Homo sapiens laminin, beta 2 (laminin S) (LAMB2), mRNA. Customized vector On-demand 30 $2699.00
OHu17891C XM_005265127 PREDICTED: Homo sapiens laminin, beta 2 (laminin S) (LAMB2), transcript variant X1, mRNA. Customized vector On-demand 30 $2699.00

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Gene Symbol LAMB2
Entrez Gene ID 3913
Full Name laminin, beta 2 (laminin S)
Synonyms LAMS, NPHS5
General protein information
Preferred Names
laminin subunit beta-2
Names
laminin subunit beta-2
laminin S
S-LAM beta
laminin B1s chain
S-laminin subunit beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21

Summary Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011].
Disorder

MIM: 150325

Nephrosis, congenital, with or without ocular abnormalities, 609049

mRNA Protein Product Sequence Price Select
NM_002292, 119703754 NP_002283, 119703755 laminin subunit beta-2 precursor ORF Sequence $2500.00
XM_005265127, 578806065 XP_005265184, 530372442 laminin subunit beta-2 isoform X1 ORF Sequence $2500.00
KEGG
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa04151PI3K-Akt signaling pathway
WikiPathways
WP453Inflammatory Response Pathway
WP244Alpha6-Beta4 Integrin Signaling Pathway
Reactome
REACT_118779Extracellular matrix organization
REACT_163906ECM proteoglycans
REACT_163874Non-integrin membrane-ECM interactions
REACT_169262Laminin interactions
Homo sapiens (human)LAMB2NP_002283.3
Pan troglodytes (chimpanzee)LAMB2XP_003309859.1
Macaca mulatta (Rhesus monkey)LAMB2XP_001110027.1
Canis lupus familiaris (dog)LAMB2XP_005632610.1
Bos taurus (cattle)LAMB2NP_001039712.2
Mus musculus (house mouse)Lamb2NP_032509.2
Rattus norvegicus (Norway rat)Lamb2NP_037106.1
Gallus gallus (chicken)LAMB2NP_989497.1
Danio rerio (zebrafish)lamb2NP_001229974.1
Drosophila melanogaster (fruit fly)LanB1NP_723319.1
Caenorhabditis eleganslam-1NP_500734.3
Xenopus (Silurana) tropicalis (western clawed frog)lamb2XP_002933101.1
Process
IDNameEvidence
GO:0007155cell adhesionIEA
GO:0007411axon guidanceIEA
GO:0007528neuromuscular junction developmentIEA
GO:0007601visual perceptionIEA
GO:0014002astrocyte developmentIEA
GO:0014044Schwann cell developmentIEA
GO:0030198extracellular matrix organizationTAS
GO:0048677axon extension involved in regenerationIEA
GO:0060041retina development in camera-type eyeIEA
GO:0072249metanephric glomerular visceral epithelial cell developmentIEA
GO:0072274metanephric glomerular basement membrane developmentIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005604basement membraneIDA
GO:0005605basal laminaTAS
GO:0005608laminin-3 complexIPI
GO:0031012extracellular matrixIDA
GO:0031012extracellular matrixISS
GO:0043260laminin-11 complexTAS
GO:0045202synapseIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005178integrin bindingIEA
GO:0005198structural molecule activityNAS
GeneCards LAMB2
UniProt P55268
Vega OTTHUMG00000156807
MIM 150325
Ensembl ENSG00000172037
HGNC 6487
HPRD 01034

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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