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LAMB2 laminin, beta 2 (laminin S) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002292 Homo sapiens laminin, beta 2 (laminin S) (LAMB2), mRNA. GenEZ ORF Cloning On-demand $2699.00 30

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Gene Symbol LAMB2
Entrez Gene ID 3913
Full Name laminin, beta 2 (laminin S)
Synonyms LAMS
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011].

MIM: 150325

Nephrosis, congenital, with or without ocular abnormalities, 609049

mRNA Protein Product Sequence Price Select
NM_002292, 119703754 NP_002283, 119703755 laminin subunit beta-2 precursor ORF Sequence $2500.00
hsa05200Pathways in cancer
hsa04510Focal adhesion
hsa04151PI3K-Akt signaling pathway
hsa04512ECM-receptor interaction
hsa05222Small cell lung cancer
WP306Focal Adhesion
WP453Inflammatory Response Pathway
WP244Alpha6-Beta4 Integrin Signaling Pathway
Homo sapiens (human)LAMB2NP_002283.3
Pan troglodytes (chimpanzee)LAMB2XP_003309859.1
Macaca mulatta (Rhesus monkey)LAMB2XP_001110027.1
Canis lupus familiaris (dog)LAMB2XP_533831.2
Bos taurus (cattle)LAMB2NP_001039712.2
Mus musculus (house mouse)Lamb2NP_032509.2
Rattus norvegicus (Norway rat)Lamb2NP_037106.1
Gallus gallus (chicken)LAMB2NP_989497.1
Danio rerio (zebrafish)lamb2XP_002666501.1
Drosophila melanogaster (fruit fly)LanB1NP_476618.1
Caenorhabditis eleganslam-1NP_500734.2
GeneCards LAMB2
UniProt P55268
MIM 150325
Ensembl ENSG00000172037
HGNC 6487
HPRD 01034

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
laminin subunit beta-2
laminin subunit beta-2
laminin S
S-LAM beta
laminin B1s chain
S-laminin subunit beta


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