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Sequence in raw or FASTA format:


Blast Method:


LAMB3 laminin, beta 3 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000228 Homo sapiens laminin, beta 3 (LAMB3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001017402 Homo sapiens laminin, beta 3 (LAMB3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001127641 Homo sapiens laminin, beta 3 (LAMB3), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005273124 PREDICTED: Homo sapiens laminin, beta 3 (LAMB3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol LAMB3
Entrez Gene ID 3914
Full Name laminin, beta 3
Synonyms BM600-125KDA, LAM5, LAMNB1
General protein information
Preferred Names
laminin subunit beta-3
laminin subunit beta-3
kalinin B1 chain
laminin B1k chain
laminin S B3 chain
nicein subunit beta
kalinin subunit beta
epiligrin subunit bata
laminin-5 subunit beta
laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD))
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

MIM: 150310

Epidermolysis bullosa, junctional, Herlitz type, 226700 (3);

mRNA Protein Product Sequence Price Select
NM_000228, 62868214 NP_000219, 62868215 laminin subunit beta-3 precursor ORF Sequence $1500.00
NM_001017402, 62868216 NP_001017402, 62868217 laminin subunit beta-3 precursor ORF Sequence $1500.00
NM_001127641, 189083718 NP_001121113, 189083719 laminin subunit beta-3 precursor ORF Sequence $1500.00
XM_005273124, 578800921 XP_005273181, 530366188 laminin subunit beta-3 isoform X1 ORF Sequence $1500.00
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
WP244Alpha6-Beta4 Integrin Signaling Pathway
REACT_20537Type I hemidesmosome assembly
REACT_20676Cell junction organization
REACT_111155Cell-Cell communication
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_120729Collagen formation
REACT_163874Non-integrin membrane-ECM interactions
REACT_150180Assembly of collagen fibrils and other multimeric structures
REACT_150268Anchoring fibril formation
REACT_169262Laminin interactions
Homo sapiens (human)LAMB3NP_001017402.1
Pan troglodytes (chimpanzee)LAMB3XP_003949737.1
Macaca mulatta (Rhesus monkey)LAMB3XP_002802197.1
Canis lupus familiaris (dog)LAMB3XP_005622385.1
Bos taurus (cattle)LAMB3NP_001075065.1
Mus musculus (house mouse)Lamb3NP_001264857.1
Rattus norvegicus (Norway rat)Lamb3NP_001094311.1
Gallus gallus (chicken)LAMB3XP_425827.3
Xenopus (Silurana) tropicalis (western clawed frog)lamb3XP_002933550.2
GO:0007155cell adhesionIEA
GO:0008544epidermis developmentTAS
GO:0022617extracellular matrix disassemblyTAS
GO:0030198extracellular matrix organizationTAS
GO:0031581hemidesmosome assemblyTAS
GO:0034329cell junction assemblyTAS
GO:0050873brown fat cell differentiationIEA
GO:0005576extracellular regionTAS
GO:0005610laminin-5 complexIEA
GO:0005198structural molecule activityNAS
GO:0005515protein bindingIPI
GO:0032403protein complex bindingIEA
GeneCards LAMB3
UniProt Q13751
Vega OTTHUMG00000036360
MIM 150310
Ensembl ENSG00000196878
HGNC 6490
HPRD 01032

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LAMB3 gene?

The LAMB3 gene provides instructions for making one part (subunit) of a protein called laminin 332 (formerly known as laminin 5). This protein is made up of three subunits, called alpha, beta, and gamma. The LAMB3 gene carries instructions for the beta subunit; the alpha and gamma subunits are produced from other genes.

Laminins are a group of proteins that regulate cell growth, cell movement (motility), and the attachment of cells to one another (adhesion). They are also involved in the formation and organization of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Laminin 332 has a particularly important role in the basement membrane that underlies the top layer of skin (the epidermis). This membrane gives strength and resiliency to the skin and creates an additional barrier between the body and its surrounding environment. Laminin 332 is a major component of fibers called anchoring filaments, which connect the two layers of the basement membrane and help hold the skin together.

Studies suggest that laminin 332 also has several other functions. This protein appears to be important for wound healing. Additionally, researchers have proposed roles for laminin 332 in the clear outer covering of the eye (the cornea) and in the development of tooth enamel.


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