Sequence in raw or FASTA format:
LAMP1 lysosomal-associated membrane protein 1 [
Homo sapiens (human)]
Gene Symbol LAMP1
Entrez Gene ID
Full Name lysosomal-associated membrane protein 1
Synonyms CD107a, LAMPA, LGP120
General protein information
lysosome-associated membrane glycoprotein 1
lysosome-associated membrane glycoprotein 1
CD107 antigen-like family member A
lysosome-associated membrane protein 1
Gene Type protein-coding
Homo sapiens (human)
Chromosome:13 Map Location:13q34
Summary The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008].
WP615 Senescence and Autophagy
ID Name Evidence
GO:0006914 autophagy IEA
GO:0008626 granzyme-mediated apoptotic signaling pathway IMP
GO:0043323 positive regulation of natural killer cell degranulation IMP
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
GO:0048102 autophagic cell death IEA
GO:0050821 protein stabilization ISS
GO:0072594 establishment of protein localization to organelle IMP
GO:0090160 Golgi to lysosome transport IMP
GO:1902513 regulation of organelle transport along microtubule IMP
Related articles in PubMed SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Xu Y, et al. Cell Rep, 2012 Dec 27. PMID 23246001. Generation and characterization of a lysosomally targeted, genetically encoded Ca(2+)-sensor. McCue HV, et al. Biochem J, 2013 Jan 15. PMID 23098255. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629. A high-throughput approach for measuring temporal changes in the interactome. Kristensen AR, et al. Nat Methods, 2012 Sep. PMID 22863883. Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome. Boita M, et al. Clin Exp Rheumatol, 2012 Jan-Feb. PMID 22640649. See all (71) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
LAMP proteins retain TAPL on the limiting membrane of endosomes and prevent its sorting to intraluminal vesicles.
Title: The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2.
Data indicate that lysosomally targeted cameleon Ca2+ probe LAMP1-YCaM accurately and sensitively responds to both global and lysosome-specific Ca2+ signals.
Title: Generation and characterization of a lysosomally targeted, genetically encoded Ca(2+)-sensor.
Report expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome.
Title: Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome.
nucleolin and LAMP-1 have a role in promoting infection of human monocytes by Francisella tularensis
Title: Nucleolin, a shuttle protein promoting infection of human monocytes by Francisella tularensis.
Human full-length amelogenin increases the proliferation of mesenchymal stem cells by interaction with LAMP1 through the MAPK-ERK signaling pathway.
Title: Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow.
Immunohistochemistry studies showed EGBs to exhibit pronounced reactivity to antibodies against lysosome-associated membrane proteins (LAMP)-1 and LAMP-2, and the lysosomal enzyme cathepsin D.
Title: Distribution of lysosome-associated membrane proteins-1 and -2, and cathepsin D in eosinophilic granular bodies: possible relationship to cyst development in pilocytic astrocytomas.
Data show that The cell surface expression levels of (ICAM)-2 and -3 on the apoptotic cells were markedly lower, while those of calnexin, calreticulin, and (LAMP)-1 and -2 were significantly higher compared to non-apoptotic cells.
Title: Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and intracellular translocation of glycoproteins.
Most Hassal's corpuscules in thymoma were negative for LAMPs, but positive in normal thymus. Both lymphocytes and epithelial cells in pathological thymus showed higher intensity for LAMP-2 compared with LAMP-1.
Title: Differential expression of LAMPs and ubiquitin in human thymus.
Despite its abundance, LAMP-1 is not essential, but LAMP-2 may be partially important for the Salmonella-containing vacuolar membrane.
Title: Effects of lysosomal membrane protein depletion on the Salmonella-containing vacuole.
the activation-induced degranulation of Fas ligand has distinct requirements and involves different mechanisms than those of the granule markers CD63 and CD107a/Lamp-1
Title: Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells.
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