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LAMP2 lysosomal-associated membrane protein 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001122606 Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant C, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_002294 Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant A, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_013995 Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant B, mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

Related Services

Gene Symbol LAMP2
Entrez Gene ID 3920
Full Name lysosomal-associated membrane protein 2
Synonyms CD107b, LAMP-2, LAMPB, LGP110
General protein information
Preferred Names
lysosome-associated membrane glycoprotein 2
Names
lysosome-associated membrane glycoprotein 2
CD107 antigen-like family member B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq24

Summary The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008].
Disorder

MIM: 309060

Glycogen storage disease IIb, 300257 (3)

mRNA Protein Product Sequence Price Select
NM_001122606, 169790832 NP_001116078, 169790833 lysosome-associated membrane glycoprotein 2 isoform C precursor ORF Sequence $400.00
NM_002294, 169790830 NP_002285, 4504957 lysosome-associated membrane glycoprotein 2 isoform A precursor ORF Sequence $269.00
NM_013995, 169790831 NP_054701, 7669503 lysosome-associated membrane glycoprotein 2 isoform B precursor ORF Sequence $400.00
KEGG
hsa04142Lysosome
hsa04145Phagosome
hsa05152Tuberculosis
WikiPathways
WP615Senescence and Autophagy
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
Homo sapiens (human)LAMP2NP_002285.1
Pan troglodytes (chimpanzee)LAMP2XP_003317709.1
Macaca mulatta (Rhesus monkey)LAMP2XP_001084005.2
Canis lupus familiaris (dog)LAMP2XP_005641822.1
Bos taurus (cattle)LAMP2NP_001029742.1
Mus musculus (house mouse)Lamp2NP_034815.2
Rattus norvegicus (Norway rat)Lamp2NP_058764.2
Gallus gallus (chicken)LAMP2NP_001001749.1
Xenopus (Silurana) tropicalis (western clawed frog)lamp2NP_001116192.2
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
GO:0050821protein stabilizationISS
Component
IDNameEvidence
GO:0005764lysosomeIDA
GO:0005765lysosomal membraneIDA
GO:0005770late endosomeIDA
GO:0005886plasma membraneTAS
GO:0016020membraneIDA
GO:0016021integral component of membraneIEA
GO:0030670phagocytic vesicle membraneIEA
GO:0031088platelet dense granule membraneIDA
GO:0031088platelet dense granule membraneTAS
GO:0031902late endosome membraneIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0019899enzyme bindingIPI
GeneCards LAMP2
UniProt P13473
Vega OTTHUMG00000022301
MIM 309060
Ensembl ENSG00000005893
HGNC 6501
HPRD 02396

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LAMP2 gene?

The LAMP2 gene provides instructions for making a protein called lysosomal associated membrane protein-2 (LAMP-2), which, as its name suggests, is found in the membrane of cellular structures called lysosomes. Lysosomes are compartments in the cell that digest and recycle materials. The role the LAMP-2 protein plays in the lysosome is unclear. Some researchers think the LAMP-2 protein may help transport cellular materials or digestive enzymes into the lysosome. The transport of cellular materials into lysosomes requires the formation of cellular structures called autophagic vacuoles (or autophagosomes). Cellular material that will be degraded in a lysosome is first enclosed in an autophagic vacuole inside the cell. The autophagic vacuole attaches (fuses) to a lysosome to transfer the cellular material into the lysosome where it can be broken down. The LAMP-2 protein may be involved in the fusion between autophagic vacuoles and lysosomes.

Slightly different versions (isoforms) of the LAMP-2 protein are produced: LAMP-2A, LAMP-2B, and LAMP-2C. These isoforms are found in different tissues throughout the body. LAMP-2B is the main isoform found in the heart and the muscles used for movement (skeletal muscles).

Interactant

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