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LAMP2 lysosomal-associated membrane protein 2 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_013995 Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant B, mRNA. Full Length $1426.60
ORF Sequence $357.57
NM_002294 Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant A, mRNA. Full Length $2971.35
ORF Sequence $357.57
NM_001122606 Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant C, mRNA. Full Length $1318.45
ORF Sequence $358.44


Gene Symbol LAMP2
Entrez Gene ID 3920
Full Name lysosomal-associated membrane protein 2
Synonyms CD107b, LAMPB, LGP110
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq24
Summary The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq].
Disorder

MIM: 309060

Glycogen storage disease IIb, 300257 (3)
mRNA NM_013995, 169790831
Protein NP_054701, 7669503
Product lysosome-associated membrane glycoprotein 2 isoform B precursor
RefSeq Status REVIEWED
mRNA NM_002294, 169790830
Protein NP_002285, 4504957
Product lysosome-associated membrane glycoprotein 2 isoform A precursor
RefSeq Status REVIEWED
mRNA NM_001122606, 169790832
Protein NP_001116078, 169790833
Product lysosome-associated membrane glycoprotein 2 isoform C precursor
RefSeq Status REVIEWED
KEGG
hsa04145Phagosome
hsa04142Lysosome
WikiPathways
WP615Senescence and Autophagy
Reactome
REACT_318Platelet degranulation
REACT_604Hemostasis
REACT_798Platelet Activation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_20Formation of Platelet plug
Homo sapiens (human)LAMP2NP_001116078.1
Canis lupus familiaris (dog)LAMP2XP_538159.2
Bos taurus (cattle)LAMP2NP_001029742.1
Mus musculus (house mouse)Lamp2NP_034815.2
Rattus norvegicus (Norway rat)Lamp2NP_058764.2
Gallus gallus (chicken)LAMP2NP_001001749.1
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
Component
IDNameEvidence
GO:0005624membrane fractionIDA
GO:0005764lysosomeIDA
GO:0005765lysosomal membraneIDA
GO:0005770late endosomeIDA
GO:0005886plasma membraneEXP
GO:0010008endosome membraneIEA
GO:0016021integral to membraneIEA
GO:0031088platelet dense granule membraneEXP
GO:0031088platelet dense granule membraneIDA
GeneCards LAMP2
UniProt Q6Q3G8, P13473
MIM 309060
Ensembl ENSG00000005893
HGNC 6501
HPRD 02396

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