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LDHA lactate dehydrogenase A [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001135239 Homo sapiens lactate dehydrogenase A (LDHA), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001165414 Homo sapiens lactate dehydrogenase A (LDHA), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001165415 Homo sapiens lactate dehydrogenase A (LDHA), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001165416 Homo sapiens lactate dehydrogenase A (LDHA), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_005566 Homo sapiens lactate dehydrogenase A (LDHA), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

*Business Day

Related Services

Gene Symbol LDHA
Entrez Gene ID 3939
Full Name lactate dehydrogenase A
Synonyms GSD11, HEL-S-133P, LDH1, LDHM
General protein information
Preferred Names
L-lactate dehydrogenase A chain
Names
L-lactate dehydrogenase A chain
LDH-A
LDH-M
LDH muscle subunit
lactate dehydrogenase M
proliferation-inducing gene 19
renal carcinoma antigen NY-REN-59
cell proliferation-inducing gene 19 protein
NP_001128711.1
NP_001158886.1
NP_001158887.1
NP_001158888.1
NP_005557.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.4

Summary The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008].
Disorder

MIM: 150000

Glycogen storage disease XI, 612933 (3)

mRNA Protein Product Sequence Price Select
NM_001135239, 207028493 NP_001128711, 207028494 L-lactate dehydrogenase A chain isoform 2 ORF Sequence $300.00
NM_001165414, 260099722 NP_001158886, 260099723 L-lactate dehydrogenase A chain isoform 3 ORF Sequence $400.00
NM_001165415, 260099724 NP_001158887, 260099725 L-lactate dehydrogenase A chain isoform 4 ORF Sequence $300.00
NM_001165416, 260099726 NP_001158888, 260099727 L-lactate dehydrogenase A chain isoform 5 ORF Sequence $250.00
NM_005566, 207028465 NP_005557, 5031857 L-lactate dehydrogenase A chain isoform 1 ORF Sequence $269.00
KEGG
hsa00010Glycolysis / Gluconeogenesis
hsa00640Propanoate metabolism
hsa00620Pyruvate metabolism
hsa00270Cysteine and methionine metabolism
hsa04066HIF-1 signaling pathway
WikiPathways
WP534Glycolysis and Gluconeogenesis
Pathway Interaction Database
hif1_tfpathwayHIF-1-alpha transcription factor network
myc_activpathwayValidated targets of C-MYC transcriptional activation
BIOCYC
HUMAN_PWY-5481pyruvate fermentation to lactate
Reactome
REACT_2071Pyruvate metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_111217Metabolism
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
Homo sapiens (human)LDHANP_001158886.1
Pan troglodytes (chimpanzee)LDHANP_001029268.1
Macaca mulatta (Rhesus monkey)LDHAXP_001086967.1
Canis lupus familiaris (dog)LDHAXP_534084.4
Bos taurus (cattle)LDHANP_776524.1
Mus musculus (house mouse)LdhaNP_001129541.2
Gallus gallus (chicken)LDHANP_990615.1
Danio rerio (zebrafish)ldhaNP_571321.1
Drosophila melanogaster (fruit fly)ImpL3NP_476581.1
Caenorhabditis elegansldh-1NP_496503.1
Arabidopsis thaliana (thale cress)AT4G17260NP_193459.1
Xenopus (Silurana) tropicalis (western clawed frog)ldhaNP_989153.1
Process
IDNameEvidence
GO:0006090pyruvate metabolic processTAS
GO:0006096glycolytic processNAS
GO:0021762substantia nigra developmentIEP
GO:0031668cellular response to extracellular stimulusIEA
GO:0044237cellular metabolic processTAS
GO:0044262cellular carbohydrate metabolic processIEA
GO:0044281small molecule metabolic processTAS
GO:0055114oxidation-reduction processIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005739mitochondrionIEA
GO:0005829cytosolTAS
GO:0005929ciliumIEA
GO:0016020membraneIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004459L-lactate dehydrogenase activityNAS
GO:0005515protein bindingIPI
GeneCards LDHA
UniProt P00338, V9HWB9
Vega OTTHUMG00000167721
MIM 150000
Ensembl ENSG00000134333
HGNC 6535
HPRD 01025

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LDHA gene?

The LDHA gene provides instructions for making a protein called lactate dehydrogenase-A, which is one piece (subunit) of the lactate dehydrogenase enzyme. There are five different forms of this enzyme, each made up of four protein subunits. Various combinations of lactate dehydrogenase-A subunits and lactate dehydrogenase-B subunits (which are produced from a different gene) make up the different forms of the enzyme. The lactate dehydrogenase enzyme is found throughout the body and is important for performing a chemical reaction that provides energy for the body.

The version of lactate dehydrogenase made of four lactate dehydrogenase-A subunits is found primarily in skeletal muscles, which are muscles used for movement. Skeletal muscles need large amounts of energy during high-intensity physical activity when the body's oxygen intake is not sufficient for the amount of energy required (anaerobic exercise). To create additional energy, glucose stored in the body as glycogen gets broken down. During the final stage of glycogen breakdown, the lactate dehydrogenase enzyme converts the molecule pyruvate into a similar molecule called lactate, which can be used by the body for energy.

Interactant

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