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LDHB lactate dehydrogenase B [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001174097 Homo sapiens lactate dehydrogenase B (LDHB), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_002300 Homo sapiens lactate dehydrogenase B (LDHB), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
XM_006719074 PREDICTED: Homo sapiens lactate dehydrogenase B (LDHB), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol LDHB
Entrez Gene ID 3945
Full Name lactate dehydrogenase B
Synonyms HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5
General protein information
Preferred Names
L-lactate dehydrogenase B chain
Names
L-lactate dehydrogenase B chain
LDH heart subunit
lactate dehydrogenase H chain
renal carcinoma antigen NY-REN-46
NP_001167568.1
NP_002291.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p12.2-p12.1

Summary This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010].
Disorder

MIM: 150100

Lactate dehydrogenase-B deficiency (3)

mRNA Protein Product Sequence Price Select
NM_001174097, 291575127 NP_001167568, 291575128 L-lactate dehydrogenase B chain ORF Sequence $269.00
NM_002300, 291575126 NP_002291, 4557032 L-lactate dehydrogenase B chain ORF Sequence $269.00
XM_006719074, 578822858 XP_006719137, 578822859 L-lactate dehydrogenase B chain isoform X1 ORF Sequence $400.00
KEGG
hsa00010Glycolysis / Gluconeogenesis
hsa00640Propanoate metabolism
hsa00620Pyruvate metabolism
hsa00270Cysteine and methionine metabolism
WikiPathways
WP534Glycolysis and Gluconeogenesis
BIOCYC
HUMAN_PWY-5481pyruvate fermentation to lactate
Reactome
REACT_2071Pyruvate metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_111217Metabolism
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
REACT_116125Disease
REACT_121117Abnormal metabolism in phenylketonuria
Homo sapiens (human)LDHBNP_002291.1
Pan troglodytes (chimpanzee)LDHBNP_001092031.1
Macaca mulatta (Rhesus monkey)LDHBXP_001094453.2
Canis lupus familiaris (dog)LDHBNP_001239093.1
Bos taurus (cattle)LDHBNP_776525.1
Mus musculus (house mouse)LdhbNP_032518.1
Rattus norvegicus (Norway rat)LdhbNP_036727.1
Gallus gallus (chicken)LDHBNP_989508.1
Danio rerio (zebrafish)ldhbbNP_001002474.1
Danio rerio (zebrafish)ldhbaNP_571322.1
Xenopus (Silurana) tropicalis (western clawed frog)ldhbNP_988882.1
Process
IDNameEvidence
GO:0006089lactate metabolic processIEA
GO:0006090pyruvate metabolic processTAS
GO:0006096glycolytic processIEA
GO:0019674NAD metabolic processIEA
GO:0044237cellular metabolic processTAS
GO:0044262cellular carbohydrate metabolic processIEA
GO:0044281small molecule metabolic processTAS
GO:0055114oxidation-reduction processIEA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005737cytoplasmTAS
GO:0005739mitochondrionIEA
GO:0005829cytosolTAS
GO:0016020membraneIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004459L-lactate dehydrogenase activityIEA
GO:0005515protein bindingIPI
GO:0019900kinase bindingIEA
GO:0042802identical protein bindingIEA
GO:0051287NAD bindingIEA
GeneCards LDHB
PDB 1I0Z, 1T2F
UniProt Q5U077, P07195
Vega OTTHUMG00000133760
MIM 150100
Ensembl ENSG00000111716
HGNC 6541
HPRD 01026

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LDHB gene?

The LDHB gene provides instructions for making a protein called lactate dehydrogenase-B, which is one piece (subunit) of the lactate dehydrogenase enzyme. There are five different forms of this enzyme, each made up of four protein subunits. Various combinations of lactate dehydrogenase-B subunits and lactate dehydrogenase-A subunits (which are produced from a different gene) make up the different forms of the enzyme. The lactate dehydrogenase enzyme, which is found throughout the body, is important for creating energy for cells. The simple sugar glucose is the energy source for most cells. In the final step of glucose breakdown, most forms of the lactate dehydrogenase enzyme convert the molecule pyruvate into a similar molecule called lactate, which can be used by the body for energy. Other forms of this enzyme can convert lactate back to pyruvate, which can participate in other chemical reactions to create energy.

The version of lactate dehydrogenase made of four lactate dehydrogenase-B subunits is found primarily in heart (cardiac) muscle. This version of the enzyme converts lactate to pyruvate.

Interactant

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