LDHB lactate dehydrogenase B [Homo sapiens (human)]
| Gene Symbol | LDHB |
| Entrez Gene ID | 3945 |
| Full Name | lactate dehydrogenase B |
| Synonyms | LDH-H, TRG-5 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
12 12p12.2-p12.1 |
| Summary | This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]. |
| Disorder | MIM: 150100 Lactate dehydrogenase-B deficiency (3) |
| mRNA | NM_002300, 291575126 |
| Protein | NP_002291, 4557032 |
| Product | L-lactate dehydrogenase B chain |
| RefSeq Status | REVIEWED |
| mRNA | NM_001174097, 291575127 |
| Protein | NP_001167568, 291575128 |
| Product | L-lactate dehydrogenase B chain |
| RefSeq Status | REVIEWED |
| hsa00640 | Propanoate metabolism |
| hsa01100 | Metabolic pathways |
| hsa00270 | Cysteine and methionine metabolism |
| hsa00010 | Glycolysis / Gluconeogenesis |
| hsa00620 | Pyruvate metabolism |
WikiPathways
| WP534 | Glycolysis and Gluconeogenesis |
Reactome
| REACT_1046 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| REACT_2071 | Pyruvate metabolism |
| Homo sapiens (human) | LDHB | NP_001167568.1 |
| Pan troglodytes (chimpanzee) | LDHB | XP_520791.2 |
| Canis lupus familiaris (dog) | LDHB | XP_534868.1 |
| Bos taurus (cattle) | LDHB | NP_776525.1 |
| Mus musculus (house mouse) | Ldhb | NP_032518.1 |
| Rattus norvegicus (Norway rat) | Ldhb | NP_036727.1 |
| Gallus gallus (chicken) | LDHB | NP_989508.1 |
| Danio rerio (zebrafish) | ldhbb | NP_001002474.1 |
| Danio rerio (zebrafish) | ldhba | NP_571322.1 |
| ID | Name | Evidence |
| GO:0006089 | lactate metabolic process | IEA |
| GO:0006090 | pyruvate metabolic process | TAS |
| GO:0006096 | glycolysis | IEA |
| GO:0019674 | NAD metabolic process | IEA |
| GO:0044262 | cellular carbohydrate metabolic process | IEA |
Component
| ID | Name | Evidence |
| GO:0005625 | soluble fraction | IEA |
| GO:0005737 | cytoplasm | TAS |
| GO:0005739 | mitochondrion | IEA |
| GO:0005829 | cytosol | TAS |
Function
| ID | Name | Evidence |
| GO:0004459 | L-lactate dehydrogenase activity | IEA |
| GO:0005488 | binding | IEA |
| GO:0016491 | oxidoreductase activity | IEA |
| GO:0042802 | identical protein binding | IEA |
| GO:0051287 | NAD binding | IEA |
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