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LEP leptin [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000230 Homo sapiens leptin (LEP), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

*Business Day

Related Services

Gene Symbol LEP
Entrez Gene ID 3952
Full Name leptin
Synonyms FLJ94114, OB, OBS
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q31.3

Summary This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008].
Disorder

MIM: 164160

Obesity, severe, due to leptin deficiency (3); Obesity, morbid, with

mRNA Protein Product Sequence Price Select
NM_000230, 169790920 NP_000221, 4557715 leptin precursor ORF Sequence $159.00
KEGG
hsa04920Adipocytokine signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
WikiPathways
WP1403AMPK signaling
WP2034Leptin signaling pathway
WP236Adipogenesis
Pathway Interaction Database
hif1_tfpathwayHIF-1-alpha transcription factor network
ptp1bpathwaySignaling events mediated by PTP1B
Reactome
REACT_23974Incretin Synthesis, Secretion, and Inactivation
REACT_24019Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_116125Disease
REACT_27161Transcriptional Regulation of White Adipocyte Differentiation
REACT_111045Developmental Biology
REACT_19189Synthesis, Secretion, and Deacylation of Ghrelin
REACT_18325Regulation of Insulin Secretion
REACT_15380Diabetes pathways
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
Homo sapiens (human)LEPNP_000221.1
Pan troglodytes (chimpanzee)LEPNP_001180601.1
Macaca mulatta (Rhesus monkey)LEPNP_001036220.1
Canis lupus familiaris (dog)LEPNP_001003070.1
Bos taurus (cattle)LEPNP_776353.2
Mus musculus (house mouse)LepNP_032519.1
Rattus norvegicus (Norway rat)LepNP_037208.1
GeneCards LEP
PDB 1AX8
UniProt P41159, A4D0Y8
MIM 164160
Ensembl ENSG00000174697
HGNC 6553
HPRD 01249

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
leptin
Names
leptin
obese protein
obesity factor
obese, mouse, homolog of
leptin (murine obesity homolog)
leptin (obesity homolog, mouse)

Interactant



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