Sequence in raw or FASTA format:

LEP leptin [Homo sapiens (human)]

Gene Symbol	LEP
Entrez Gene ID	3952
Full Name	leptin
Synonyms	FLJ94114, OB, OBS
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:7 Map Location:7q31.3
Summary	This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq].
Disorder	MIM: 164160 Obesity, severe, due to leptin deficiency (3); Obesity, morbid, with

KEGG

hsa04920	Adipocytokine signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04630	Jak-STAT signaling pathway
hsa04080	Neuroactive ligand-receptor interaction

WikiPathways

WP236

Adipogenesis

Pathway Interaction Database

ptp1bpathway	Signaling events mediated by PTP1B
hif1_tfpathway	HIF-1-alpha transcription factor network

Reactome

REACT_19189	Synthesis, Secretion, and Deacylation of Ghrelin
REACT_15380	Diabetes pathways
REACT_18325	Regulation of Insulin Secretion
REACT_1505	Integration of energy metabolism
REACT_23974	Incretin Synthesis, Secretion, and Inactivation
REACT_24019	Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)

Homo sapiens (human)	LEP	NP_000221.1
Pan troglodytes (chimpanzee)	LEP	XP_519353.2
Canis lupus familiaris (dog)	LEP	NP_001003070.1
Bos taurus (cattle)	LEP	NP_776353.2
Mus musculus (house mouse)	Lep	NP_032519.1
Rattus norvegicus (Norway rat)	Lep	NP_037208.1

Process

ID	Name	Evidence
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA
GO:0001542	ovulation from ovarian follicle	IEA
GO:0001890	placenta development	IDA
GO:0001932	regulation of protein phosphorylation	IEA
GO:0002021	response to dietary excess	IEA
GO:0006006	glucose metabolic process	IEA
GO:0006111	regulation of gluconeogenesis	IEA
GO:0006112	energy reserve metabolic process	IEA
GO:0006629	lipid metabolic process	IEA
GO:0007165	signal transduction	IEA
GO:0008203	cholesterol metabolic process	IEA
GO:0008206	bile acid metabolic process	IEA
GO:0008343	adult feeding behavior	ISS
GO:0009062	fatty acid catabolic process	IEA
GO:0009892	negative regulation of metabolic process	IEA
GO:0021954	central nervous system neuron development	IEA
GO:0030300	regulation of intestinal cholesterol absorption	IEA
GO:0032099	negative regulation of appetite	ISS
GO:0032868	response to insulin stimulus	IEA
GO:0033210	leptin-mediated signaling pathway	IEA
GO:0042307	positive regulation of protein import into nucleus	IEA
GO:0042445	hormone metabolic process	IEA
GO:0042755	eating behavior	IEA
GO:0043410	positive regulation of MAPKKK cascade	IEA
GO:0045639	positive regulation of myeloid cell differentiation	IEA
GO:0046427	positive regulation of JAK-STAT cascade	IEA
GO:0048639	positive regulation of developmental growth	IDA
GO:0050796	regulation of insulin secretion	IEA
GO:0050810	regulation of steroid biosynthetic process	IEA
GO:0070093	negative regulation of glucagon secretion	IEA

Component

Function

ID	Name	Evidence
GO:0005179	hormone activity	IEA
GO:0008083	growth factor activity	IEA
GO:0051428	peptide hormone receptor binding	IEA

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