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LEP leptin [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu27387 NM_000230 Homo sapiens leptin (LEP), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu41550 XM_005250340 PREDICTED: Homo sapiens leptin (LEP), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu27387C NM_000230 Homo sapiens leptin (LEP), mRNA. Customized vector In-stock 5-7 $149.00
OHu41550C XM_005250340 PREDICTED: Homo sapiens leptin (LEP), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol LEP
Entrez Gene ID 3952
Full Name leptin
Synonyms LEPD, OB, OBS
General protein information
Preferred Names
leptin
Names
leptin
obese protein
obesity factor
obese, mouse, homolog of
leptin (murine obesity homolog)
leptin (obesity homolog, mouse)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q31.3

Summary This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008].
Disorder

MIM: 164160

Obesity, severe, due to leptin deficiency (3); Obesity, morbid, with

mRNA Protein Product Sequence Price Select
NM_000230, 169790920 NP_000221, 4557715 leptin precursor ORF Sequence $159.00
XM_005250340, 578814244 XP_005250397, 530385892 leptin isoform X1 ORF Sequence $250.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04152AMPK signaling pathway
WikiPathways
WP1403AMPK signaling
WP236Adipogenesis
WP2034Leptin signaling pathway
WP2431Spinal Cord Injury
Pathway Interaction Database
ptp1bpathwaySignaling events mediated by PTP1B
hif1_tfpathwayHIF-1-alpha transcription factor network
Reactome
REACT_19189Synthesis, secretion, and deacylation of Ghrelin
REACT_17015Metabolism of proteins
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_24019Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_23974Incretin synthesis, secretion, and inactivation
REACT_111045Developmental Biology
REACT_111102Signal Transduction
REACT_169118Signaling by Leptin
REACT_160078Peptide hormone metabolism
Homo sapiens (human)LEPNP_000221.1
Pan troglodytes (chimpanzee)LEPNP_001180601.1
Macaca mulatta (Rhesus monkey)LEPNP_001036220.1
Canis lupus familiaris (dog)LEPNP_001003070.1
Bos taurus (cattle)LEPNP_776353.2
Mus musculus (house mouse)LepNP_032519.1
Rattus norvegicus (Norway rat)LepNP_037208.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100486715XP_002931881.2
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001542ovulation from ovarian follicleIEA
GO:0001666response to hypoxiaIEA
GO:0001819positive regulation of cytokine productionIEA
GO:0001890placenta developmentIDA
GO:0002021response to dietary excessIEA
GO:0006006glucose metabolic processIEA
GO:0006111regulation of gluconeogenesisIEA
GO:0006112energy reserve metabolic processIEA
GO:0006114glycerol biosynthetic processIEA
GO:0007260tyrosine phosphorylation of STAT proteinIEA
GO:0007565female pregnancyIEA
GO:0007623circadian rhythmIEA
GO:0008203cholesterol metabolic processIEA
GO:0008206bile acid metabolic processIEA
GO:0008217regulation of blood pressureIEA
GO:0008284positive regulation of cell proliferationIEA
GO:0008343adult feeding behaviorISS
GO:0009062fatty acid catabolic processIEA
GO:0021954central nervous system neuron developmentIEA
GO:0030073insulin secretionIEA
GO:0030300regulation of intestinal cholesterol absorptionIEA
GO:0032099negative regulation of appetiteISS
GO:0032868response to insulinIEA
GO:0033197response to vitamin EIEA
GO:0033210leptin-mediated signaling pathwayIEA
GO:0033686positive regulation of luteinizing hormone secretionIEA
GO:0035630bone mineralization involved in bone maturationIEA
GO:0042445hormone metabolic processIEA
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIEA
GO:0042755eating behaviorIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0043270positive regulation of ion transportIEA
GO:0043410positive regulation of MAPK cascadeIEA
GO:0045598regulation of fat cell differentiationIEA
GO:0045639positive regulation of myeloid cell differentiationIEA
GO:0045906negative regulation of vasoconstrictionIEA
GO:0046628positive regulation of insulin receptor signaling pathwayIEA
GO:0046881positive regulation of follicle-stimulating hormone secretionIEA
GO:0048639positive regulation of developmental growthIDA
GO:0050796regulation of insulin secretionIEA
GO:0050810regulation of steroid biosynthetic processIEA
GO:0050901leukocyte tethering or rollingIEA
GO:0060587regulation of lipoprotein lipid oxidationIEA
GO:0060612adipose tissue developmentIEA
GO:0061037negative regulation of cartilage developmentIEA
GO:0070093negative regulation of glucagon secretionIEA
GO:0071298cellular response to L-ascorbic acidIEA
GO:0071300cellular response to retinoic acidIEA
GO:2000366positive regulation of STAT protein import into nucleusIEA
GO:2000486negative regulation of glutamine transportIEA
GO:2000491positive regulation of hepatic stellate cell activationIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceISS
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0005179hormone activityIEA
GO:0008083growth factor activityIEA
GO:0051428peptide hormone receptor bindingIEA
GeneCards LEP
PDB 1AX8
UniProt P41159, A4D0Y8
Vega OTTHUMG00000157564
MIM 164160
Ensembl ENSG00000174697
HGNC 6553
HPRD 01249

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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