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LIPC lipase, hepatic [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000236 Homo sapiens lipase, hepatic (LIPC), mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005254372 PREDICTED: Homo sapiens lipase, hepatic (LIPC), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005254374 PREDICTED: Homo sapiens lipase, hepatic (LIPC), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006720501 PREDICTED: Homo sapiens lipase, hepatic (LIPC), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006720502 PREDICTED: Homo sapiens lipase, hepatic (LIPC), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol LIPC
Entrez Gene ID 3990
Full Name lipase, hepatic
Synonyms HDLCQ12, HL, HTGL, LIPH
General protein information
Preferred Names
hepatic triacylglycerol lipase
Names
hepatic triacylglycerol lipase
hepatic lipase
lipase member C
NP_000227.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q21-q23

Summary LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008].
Disorder

MIM: 151670

Hepatic lipase deficiency (3); [High density lipoprotein cholesterol

mRNA Protein Product Sequence Price Select
NM_000236, 194097334 NP_000227, 194097335 hepatic triacylglycerol lipase precursor ORF Sequence $550.00
XM_005254372, 530405831 XP_005254429, 530405832 hepatic triacylglycerol lipase isoform X1 ORF Sequence $550.00
XM_005254374, 578826909 XP_005254431, 530405836 hepatic triacylglycerol lipase isoform X3 ORF Sequence $550.00
XM_006720501, 578826907 XP_006720564, 578826908 hepatic triacylglycerol lipase isoform X4 ORF Sequence $550.00
XM_006720502, 578826910 XP_006720565, 578826911 hepatic triacylglycerol lipase isoform X5 ORF Sequence $550.00
KEGG
hsa00561Glycerolipid metabolism
hsa_M00098Acylglycerol degradation
WikiPathways
WP143Fatty Acid Beta Oxidation
WP325Triacylglyceride Synthesis
WP430Statin Pathway
BIOCYC
HUMAN_LIPAS-PWYtriacylglycerol degradation
HUMAN_PWY-6857retinol biosynthesis
Reactome
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_6841Chylomicron-mediated lipid transport
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
Homo sapiens (human)LIPCNP_000227.2
Pan troglodytes (chimpanzee)LIPCXP_001172241.1
Macaca mulatta (Rhesus monkey)LIPCXP_001095252.1
Canis lupus familiaris (dog)LIPCXP_535495.3
Bos taurus (cattle)LIPCNP_001030487.1
Mus musculus (house mouse)LipcNP_032306.2
Rattus norvegicus (Norway rat)LipcNP_036729.2
Gallus gallus (chicken)LIPCXP_425067.4
Danio rerio (zebrafish)lipcaNP_957316.1
Xenopus (Silurana) tropicalis (western clawed frog)lipcNP_001107731.1
Process
IDNameEvidence
GO:0006633fatty acid biosynthetic processIDA
GO:0008203cholesterol metabolic processIEA
GO:0019433triglyceride catabolic processIDA
GO:0034372very-low-density lipoprotein particle remodelingIDA
GO:0034373intermediate-density lipoprotein particle remodelingTAS
GO:0034374low-density lipoprotein particle remodelingIMP
GO:0034375high-density lipoprotein particle remodelingIMP
GO:0034382chylomicron remnant clearanceTAS
GO:0034638phosphatidylcholine catabolic processTAS
GO:0042632cholesterol homeostasisIMP
GO:0043691reverse cholesterol transportIC
GO:0070328triglyceride homeostasisIMP
Component
IDNameEvidence
GO:0005615extracellular spaceIDA
GO:0034364high-density lipoprotein particleIEA
Function
IDNameEvidence
GO:0004620phospholipase activityTAS
GO:0004806triglyceride lipase activityIDA
GO:0008201heparin bindingIEA
GO:0030169low-density lipoprotein particle bindingISS
GO:0034185apolipoprotein bindingISS
GeneCards LIPC
UniProt A6H8L5, P11150
Vega OTTHUMG00000132632
MIM 151670
Ensembl ENSG00000166035
HGNC 6619
HPRD 01058

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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