LIPC lipase, hepatic [Homo sapiens (human)]
| Gene Symbol | LIPC |
| Entrez Gene ID | 3990 |
| Full Name | lipase, hepatic |
| Synonyms | HDLCQ12, HL, HTGL, LIPH |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
15 15q21-q23 |
| Summary | LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq]. |
| Disorder | MIM: 151670 Hepatic lipase deficiency (3); [High density lipoprotein cholesterol |
| mRNA | NM_000236, 194097334 |
| Protein | NP_000227, 194097335 |
| Product | hepatic triacylglycerol lipase precursor |
| RefSeq Status | REVIEWED |
| hsa01100 | Metabolic pathways |
| hsa00561 | Glycerolipid metabolism |
WikiPathways
| WP143 | Fatty Acid Beta Oxidation |
| WP430 | Statin Pathway |
| WP325 | Triacylglyceride Synthesis |
Reactome
| REACT_6841 | Chylomicron-mediated lipid transport |
| REACT_6823 | Lipoprotein metabolism |
| REACT_602 | Lipid digestion, mobilization, and transport |
| REACT_22258 | Metabolism of lipids and lipoproteins |
| Homo sapiens (human) | LIPC | NP_000227.2 |
| Pan troglodytes (chimpanzee) | LIPC | XP_001172231.1 |
| Canis lupus familiaris (dog) | LIPC | XP_535495.2 |
| Bos taurus (cattle) | LIPC | NP_001030487.1 |
| Mus musculus (house mouse) | Lipc | NP_032306.2 |
| Rattus norvegicus (Norway rat) | Lipc | NP_036729.2 |
| Gallus gallus (chicken) | LIPC | XP_425067.2 |
| Danio rerio (zebrafish) | lipc | NP_957316.1 |
| ID | Name | Evidence |
| GO:0006633 | fatty acid biosynthetic process | IDA |
| GO:0008203 | cholesterol metabolic process | IEA |
| GO:0016042 | lipid catabolic process | IEA |
| GO:0019433 | triglyceride catabolic process | IDA |
| GO:0034372 | very-low-density lipoprotein particle remodeling | IDA |
| GO:0034373 | intermediate-density lipoprotein particle remodeling | TAS |
| GO:0034374 | low-density lipoprotein particle remodeling | IMP |
| GO:0034375 | high-density lipoprotein particle remodeling | IMP |
| GO:0034382 | chylomicron remnant clearance | TAS |
| GO:0034638 | phosphatidylcholine catabolic process | TAS |
| GO:0042632 | cholesterol homeostasis | IMP |
| GO:0043691 | reverse cholesterol transport | IC |
| GO:0070328 | triglyceride homeostasis | IMP |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0005615 | extracellular space | IDA |
| GO:0034364 | high-density lipoprotein particle | IEA |
Function
| ID | Name | Evidence |
| GO:0004620 | phospholipase activity | TAS |
| GO:0004806 | triglyceride lipase activity | IDA |
| GO:0008201 | heparin binding | IEA |
| GO:0016787 | hydrolase activity | IEA |
| GO:0030169 | low-density lipoprotein particle binding | ISS |
| GO:0034185 | apolipoprotein binding | ISS |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |