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LMNA lamin A/C [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001257374 Homo sapiens lamin A/C (LMNA), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_005572 Homo sapiens lamin A/C (LMNA), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_170707 Homo sapiens lamin A/C (LMNA), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_170708 Homo sapiens lamin A/C (LMNA), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol LMNA
Entrez Gene ID 4000
Full Name lamin A/C
Synonyms CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q22

Summary The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012].
Disorder

MIM: 150330

Emery-Dreifuss muscular dystrophy, AD, 181350 (3); Cardiomyopathy, dilated, 1A, 115200 (3); Lipodystrophy, familial partial, 151660 (3);

mRNA Protein Product Sequence Price Select
NM_001257374, 383792149 NP_001244303, 383792150 lamin isoform D ORF Sequence $700.00
NM_005572, 153281091 NP_005563, 5031875 lamin isoform C ORF Sequence $490.00
NM_170707, 383792147 NP_733821, 27436946 lamin isoform A ORF Sequence $490.00
NM_170708, 383792148 NP_733822, 27436948 lamin isoform A-delta10 ORF Sequence $700.00
KEGG
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Pathway Interaction Database
caspase_pathwayCaspase cascade in apoptosis
WikiPathways
WP2118Arrhythmogenic right ventricular cardiomyopathy
WP314FAS pathway and Stress induction of HSP regulation
WP236Adipogenesis
Reactome
REACT_116125Disease
REACT_111183Meiosis
REACT_22172Chromosome Maintenance
REACT_75792Meiotic Synapsis
REACT_18273Activation of Chaperone Genes by XBP1(S)
REACT_18368Activation of Chaperones by IRE1alpha
REACT_578Apoptosis
REACT_995Apoptotic execution phase
REACT_13472Breakdown of the nuclear lamina
REACT_15380Diabetes pathways
REACT_18356Unfolded Protein Response
REACT_115566Cell Cycle
REACT_107Apoptotic cleavage of cellular proteins
Homo sapiens (human)LMNANP_733821.1
Pan troglodytes (chimpanzee)LMNANP_001092024.1
Macaca mulatta (Rhesus monkey)LMNAXP_001113604.2
Canis lupus familiaris (dog)LMNAXP_864434.1
Bos taurus (cattle)LMNANP_001029225.1
Mus musculus (house mouse)LmnaNP_001002011.2
Rattus norvegicus (Norway rat)LmnaNP_001002016.1
Danio rerio (zebrafish)lmnaNP_694503.1
GeneCards LMNA
PDB 3V5B, 1IFR, 1IVT, 3V4Q, 1X8Y, 3V4W, 2XV5, 3GEF
UniProt P02545
MIM 150330
Ensembl ENSG00000160789
HGNC 6636
HPRD 01035

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
lamin
Names
lamin
70 kDa lamin
prelamin-A/C
lamin A/C-like 1
renal carcinoma antigen NY-REN-32

Interactant



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