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LMNA lamin A/C [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16808 NM_001282625 Homo sapiens lamin A/C (LMNA), transcript variant 6, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20696 NM_170708 Homo sapiens lamin A/C (LMNA), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu21250 NM_170707 Homo sapiens lamin A/C (LMNA), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu22769 NM_001257374 Homo sapiens lamin A/C (LMNA), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16808 NM_005572 Homo sapiens lamin A/C (LMNA), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu27626 NM_001282624 Homo sapiens lamin A/C (LMNA), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu27661 NM_001282626 Homo sapiens lamin A/C (LMNA), transcript variant 7, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16808C NM_001282625 Homo sapiens lamin A/C (LMNA), transcript variant 6, mRNA. Customized vector On-demand 7-9 $269.00
OHu20696C NM_170708 Homo sapiens lamin A/C (LMNA), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu21250C NM_170707 Homo sapiens lamin A/C (LMNA), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu22769C NM_001257374 Homo sapiens lamin A/C (LMNA), transcript variant 4, mRNA. Customized vector On-demand 7-9 $269.00
OHu16808C NM_005572 Homo sapiens lamin A/C (LMNA), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu27626C NM_001282624 Homo sapiens lamin A/C (LMNA), transcript variant 5, mRNA. Customized vector On-demand 7-9 $269.00
OHu27661C NM_001282626 Homo sapiens lamin A/C (LMNA), transcript variant 7, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol LMNA
Entrez Gene ID 4000
Full Name lamin A/C
Synonyms CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
General protein information
Preferred Names
lamin
Names
lamin
70 kDa lamin
prelamin-A/C
lamin A/C-like 1
renal carcinoma antigen NY-REN-32
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q22

Summary The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012].
Disorder

MIM: 150330

Emery-Dreifuss muscular dystrophy, AD, 181350 (3); Cardiomyopathy, dilated, 1A, 115200 (3); Lipodystrophy, familial partial, 151660 (3);

mRNA Protein Product Sequence Price Select
NM_001257374, 544063462 NP_001244303, 383792150 lamin isoform D ORF Sequence $700.00
NM_001282624, 544063463 NP_001269553, 544063464 lamin isoform E ORF Sequence $550.00
NM_001282625, 544063465 NP_001269554, 544063466 lamin isoform C ORF Sequence $700.00
NM_001282626, 544063467 NP_001269555, 544063468 lamin isoform A-delta50 ORF Sequence $700.00
NM_005572, 153281091 NP_005563, 5031875 lamin isoform C ORF Sequence $490.00
NM_170707, 383792147 NP_733821, 27436946 lamin isoform A ORF Sequence $490.00
NM_170708, 383792148 NP_733822, 27436948 lamin isoform A-delta10 ORF Sequence $700.00
KEGG
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
WikiPathways
WP236Adipogenesis
WP314FAS pathway and Stress induction of HSP regulation
WP2118Arrhythmogenic right ventricular cardiomyopathy
Pathway Interaction Database
caspase_pathwayCaspase cascade in apoptosis
Reactome
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_13472Breakdown of the nuclear lamina
REACT_152Cell Cycle, Mitotic
REACT_995Apoptotic execution phase
REACT_765Mitotic Prophase
REACT_1275Mitotic Anaphase
REACT_910M Phase
REACT_18356Unfolded Protein Response (UPR)
REACT_18368IRE1alpha activates chaperones
REACT_17015Metabolism of proteins
REACT_111183Meiosis
REACT_75792Meiotic synapsis
REACT_115566Cell Cycle
REACT_18273XBP1(S) activates chaperone genes
REACT_150314Mitotic Metaphase and Anaphase
REACT_160242Initiation of Nuclear Envelope Reformation
REACT_160113Nuclear Envelope Reassembly
REACT_160255Nuclear Envelope Breakdown
REACT_200828Depolymerisation of the Nuclear Lamina
Homo sapiens (human)LMNANP_733821.1
Pan troglodytes (chimpanzee)LMNANP_001092024.1
Macaca mulatta (Rhesus monkey)LMNAXP_001113604.2
Canis lupus familiaris (dog)LMNAXP_005622768.1
Bos taurus (cattle)LMNANP_001029225.1
Mus musculus (house mouse)LmnaNP_001002011.2
Rattus norvegicus (Norway rat)LmnaNP_001002016.1
Danio rerio (zebrafish)lmnaNP_694503.1
Xenopus (Silurana) tropicalis (western clawed frog)lmnaNP_001039148.1
Process
IDNameEvidence
GO:0000278mitotic cell cycleTAS
GO:0006915apoptotic processTAS
GO:0006921cellular component disassembly involved in execution phase of apoptosisTAS
GO:0006987activation of signaling protein activity involved in unfolded protein responseTAS
GO:0007077mitotic nuclear envelope disassemblyTAS
GO:0007084mitotic nuclear envelope reassemblyTAS
GO:0007517muscle organ developmentIMP
GO:0030334regulation of cell migrationISS
GO:0030951establishment or maintenance of microtubule cytoskeleton polarityISS
GO:0030968endoplasmic reticulum unfolded protein responseTAS
GO:0034504protein localization to nucleusISS
GO:0035105sterol regulatory element binding protein import into nucleusIEA
GO:0044267cellular protein metabolic processTAS
GO:0055015ventricular cardiac muscle cell developmentIEA
GO:0071456cellular response to hypoxiaIEP
GO:0090201negative regulation of release of cytochrome c from mitochondriaIEA
GO:0090343positive regulation of cell agingIDA
GO:2001237negative regulation of extrinsic apoptotic signaling pathwayIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005635nuclear envelopeIDA
GO:0005635nuclear envelopeTAS
GO:0005638lamin filamentIEA
GO:0005638lamin filamentTAS
GO:0005652nuclear laminaTAS
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005882intermediate filamentTAS
GO:0016607nuclear speckIEA
GO:0048471perinuclear region of cytoplasmIDA
Function
IDNameEvidence
GO:0005198structural molecule activityIEA
GO:0005198structural molecule activityTAS
GO:0005515protein bindingIPI
GeneCards LMNA
UniProt Q5TCI8, P02545
Vega OTTHUMG00000013961
MIM 150330
Ensembl ENSG00000160789
HGNC 6636
HPRD 01035

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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