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LPL lipoprotein lipase [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25014 NM_000237 Homo sapiens lipoprotein lipase (LPL), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25014C NM_000237 Homo sapiens lipoprotein lipase (LPL), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol LPL
Entrez Gene ID 4023
Full Name lipoprotein lipase
Synonyms HDLCQ11, LIPD
General protein information
Preferred Names
lipoprotein lipase
Names
lipoprotein lipase
NP_000228.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p22

Summary LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008].
Disorder

MIM: 609708

Lipoprotein lipase deficiency, 238600 (3); Combined hyperlipidemia,

mRNA Protein Product Sequence Price Select
NM_000237, 145275217 NP_000228, 4557727 lipoprotein lipase precursor ORF Sequence $550.00
KEGG
hsa00561Glycerolipid metabolism
hsa03320PPAR signaling pathway
hsa05010Alzheimer's disease
WikiPathways
WP1982SREBP signalling
WP716Vitamin A and carotenoid metabolism
WP143Fatty Acid Beta Oxidation
WP325Triacylglyceride Synthesis
WP236Adipogenesis
WP430Statin Pathway
WP2059Alzheimers Disease
Reactome
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_6841Chylomicron-mediated lipid transport
REACT_22258Metabolism of lipids and lipoproteins
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_24968Retinoid metabolism and transport
REACT_111217Metabolism
REACT_111045Developmental Biology
REACT_111102Signal Transduction
REACT_116125Disease
REACT_160102Diseases associated with visual transduction
REACT_160125Visual phototransduction
Homo sapiens (human)LPLNP_000228.1
Pan troglodytes (chimpanzee)LPLXP_001149804.1
Canis lupus familiaris (dog)LPLXP_005635791.1
Bos taurus (cattle)LPLNP_001068588.1
Mus musculus (house mouse)LplNP_032535.2
Rattus norvegicus (Norway rat)LplNP_036730.1
Gallus gallus (chicken)LPLNP_990613.1
Danio rerio (zebrafish)lplNP_571202.1
Danio rerio (zebrafish)LOC101884800XP_005174466.1
Xenopus (Silurana) tropicalis (western clawed frog)lplXP_002934038.1
Process
IDNameEvidence
GO:0001523retinoid metabolic processTAS
GO:0006633fatty acid biosynthetic processIC
GO:0006633fatty acid biosynthetic processIDA
GO:0006633fatty acid biosynthetic processISS
GO:0006641triglyceride metabolic processISS
GO:0006644phospholipid metabolic processISS
GO:0007603phototransduction, visible lightTAS
GO:0009409response to coldIEA
GO:0010744positive regulation of macrophage derived foam cell differentiationIC
GO:0010886positive regulation of cholesterol storageIMP
GO:0010890positive regulation of sequestering of triglycerideIMP
GO:0019432triglyceride biosynthetic processIEA
GO:0019433triglyceride catabolic processIDA
GO:0019433triglyceride catabolic processISS
GO:0034371chylomicron remodelingIC
GO:0034372very-low-density lipoprotein particle remodelingIDA
GO:0034372very-low-density lipoprotein particle remodelingISS
GO:0042157lipoprotein metabolic processTAS
GO:0042493response to drugIEA
GO:0044281small molecule metabolic processTAS
GO:0070328triglyceride homeostasisIGI
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneIEA
GO:0009986cell surfaceIEA
GO:0031012extracellular matrixIEA
GO:0031225anchored component of membraneIEA
GO:0034361very-low-density lipoprotein particleIEA
GO:0042627chylomicronIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004465lipoprotein lipase activityIDA
GO:0004465lipoprotein lipase activityISS
GO:0004620phospholipase activityISS
GO:0004806triglyceride lipase activityIDA
GO:0004806triglyceride lipase activityISS
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GO:0008201heparin bindingIDA
GO:0017129triglyceride bindingIEA
GO:0034185apolipoprotein bindingIPI
GeneCards LPL
UniProt P06858
Vega OTTHUMG00000036645
MIM 609708
Ensembl ENSG00000175445
HGNC 6677
HPRD 01999

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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