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LPL lipoprotein lipase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000237 Homo sapiens lipoprotein lipase (LPL), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol LPL
Entrez Gene ID 4023
Full Name lipoprotein lipase
Synonyms HDLCQ11, LIPD
General protein information
Preferred Names
lipoprotein lipase
Names
lipoprotein lipase
NP_000228.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p22

Summary LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008].
Disorder

MIM: 609708

Lipoprotein lipase deficiency, 238600 (3); Combined hyperlipidemia,

mRNA Protein Product Sequence Price Select
NM_000237, 145275217 NP_000228, 4557727 lipoprotein lipase precursor ORF Sequence $550.00
KEGG
hsa00561Glycerolipid metabolism
hsa03320PPAR signaling pathway
hsa05010Alzheimer's disease
WikiPathways
WP1982SREBP signalling
WP716Vitamin A and carotenoid metabolism
WP143Fatty Acid Beta Oxidation
WP325Triacylglyceride Synthesis
WP236Adipogenesis
WP430Statin Pathway
WP2059Alzheimers Disease
Reactome
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_6841Chylomicron-mediated lipid transport
REACT_22258Metabolism of lipids and lipoproteins
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_24968Retinoid metabolism and transport
REACT_111217Metabolism
REACT_111045Developmental Biology
REACT_111102Signal Transduction
REACT_116125Disease
REACT_160102Diseases associated with visual transduction
REACT_160125Visual phototransduction
Homo sapiens (human)LPLNP_000228.1
Pan troglodytes (chimpanzee)LPLXP_001149804.1
Canis lupus familiaris (dog)LPLXP_005635791.1
Bos taurus (cattle)LPLNP_001068588.1
Mus musculus (house mouse)LplNP_032535.2
Rattus norvegicus (Norway rat)LplNP_036730.1
Gallus gallus (chicken)LPLNP_990613.1
Danio rerio (zebrafish)lplNP_571202.1
Danio rerio (zebrafish)LOC101884800XP_005174466.1
Xenopus (Silurana) tropicalis (western clawed frog)lplXP_002934038.1
Process
IDNameEvidence
GO:0001523retinoid metabolic processTAS
GO:0006633fatty acid biosynthetic processIC
GO:0006633fatty acid biosynthetic processIDA
GO:0006633fatty acid biosynthetic processISS
GO:0006641triglyceride metabolic processISS
GO:0006644phospholipid metabolic processISS
GO:0007603phototransduction, visible lightTAS
GO:0009409response to coldIEA
GO:0010744positive regulation of macrophage derived foam cell differentiationIC
GO:0010886positive regulation of cholesterol storageIMP
GO:0010890positive regulation of sequestering of triglycerideIMP
GO:0019432triglyceride biosynthetic processIEA
GO:0019433triglyceride catabolic processIDA
GO:0019433triglyceride catabolic processISS
GO:0034371chylomicron remodelingIC
GO:0034372very-low-density lipoprotein particle remodelingIDA
GO:0034372very-low-density lipoprotein particle remodelingISS
GO:0042157lipoprotein metabolic processTAS
GO:0042493response to drugIEA
GO:0044281small molecule metabolic processTAS
GO:0070328triglyceride homeostasisIGI
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneIEA
GO:0009986cell surfaceIEA
GO:0031012extracellular matrixIEA
GO:0031225anchored component of membraneIEA
GO:0034361very-low-density lipoprotein particleIEA
GO:0042627chylomicronIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004465lipoprotein lipase activityIDA
GO:0004465lipoprotein lipase activityISS
GO:0004620phospholipase activityISS
GO:0004806triglyceride lipase activityIDA
GO:0004806triglyceride lipase activityISS
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GO:0008201heparin bindingIDA
GO:0017129triglyceride bindingIEA
GO:0034185apolipoprotein bindingIPI
GeneCards LPL
UniProt P06858
Vega OTTHUMG00000036645
MIM 609708
Ensembl ENSG00000175445
HGNC 6677
HPRD 01999

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LPL gene?

The LPL gene provides instructions for making an enzyme called lipoprotein lipase. This enzyme is made primarily in fatty (adipose) tissue and in muscle. It plays a critical role in transporting fats and breaking down fat-carrying molecules called lipoproteins.

Lipoprotein lipase removes fatty substances from two types of lipoproteins: chylomicrons and very low density lipoproteins (VLDLs). After a meal, chylomicrons are formed to carry fat from the intestine into the bloodstream. VLDLs are molecules that circulate in the blood, carrying fat and cholesterol from the liver to other tissues throughout the body. Lipoprotein lipase works with another enzyme (apolipoprotein C-II) to remove fats from chylomicrons and VLDLs. The breakdown of these particles releases fat molecules for energy use or for storage in adipose tissue.

Interactant

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