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LPL lipoprotein lipase [Homo sapiens (human)]

RefSeq Accession Definition Services Price Order
NM_000237 Homo sapiens lipoprotein lipase (LPL), mRNA. ORF Sequence $414.12
Peptide Services
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Gene Symbol LPL
Entrez Gene ID 4023
Full Name lipoprotein lipase
Synonyms HDLCQ11, LIPD
Gene Type protein-coding
Organism Homo sapiens (human)



Summary LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008].

MIM: 609708

Lipoprotein lipase deficiency, 238600 (3); Combined hyperlipidemia,

mRNA Protein Product Sequence Price Select
NM_000237, 145275217 NP_000228, 4557727 lipoprotein lipase precursor Full Length $1311.45
ORF Sequence $414.12
hsa00561Glycerolipid metabolism
hsa03320PPAR signaling pathway
hsa05010Alzheimer's disease
WP430Statin Pathway
WP325Triacylglyceride Synthesis
WP716Vitamin A and carotenoid metabolism
WP2059Alzheimers Disease
WP143Fatty Acid Beta Oxidation
WP1982SREBP signalling
REACT_6841Chylomicron-mediated lipid transport
REACT_27161Transcriptional Regulation of White Adipocyte Differentiation
REACT_111045Developmental Biology
REACT_6823Lipoprotein metabolism
REACT_602Lipid digestion, mobilization, and transport
REACT_22258Metabolism of lipids and lipoproteins
Homo sapiens (human)LPLNP_000228.1
Pan troglodytes (chimpanzee)LPLXP_001149804.1
Canis lupus familiaris (dog)LPLXP_534584.3
Bos taurus (cattle)LPLNP_001068588.1
Mus musculus (house mouse)LplNP_032535.2
Rattus norvegicus (Norway rat)LplNP_036730.1
Gallus gallus (chicken)LPLNP_990613.1
Danio rerio (zebrafish)lplNP_571202.1
GeneCards LPL
UniProt P06858
MIM 609708
Ensembl ENSG00000175445
HGNC 6677
HPRD 01999

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
lipoprotein lipase
lipoprotein lipase


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