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LRP5 low density lipoprotein receptor-related protein 5 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002335 Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5), mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol LRP5
Entrez Gene ID 4041
Full Name low density lipoprotein receptor-related protein 5
Synonyms BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13.4

Summary This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. [provided by RefSeq, Nov 2009].
Disorder

MIM: 603506

Osteoporosis-pseudoglioma syndrome, 259770 (3); [Bone mineral density

mRNA Protein Product Sequence Price Select
NM_002335, 119709831 NP_002326, 119709832 low-density lipoprotein receptor-related protein 5 precursor ORF Sequence $2500.00
KEGG
hsa04310Wnt signaling pathway
Pathway Interaction Database
ncadherinpathwayN-cadherin signaling events
wnt_signaling_pathwayWnt signaling network
WikiPathways
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP399Wnt Signaling Pathway and Pluripotency
WP363Wnt Signaling Pathway NetPath
Homo sapiens (human)LRP5NP_002326.2
Pan troglodytes (chimpanzee)LRP5XP_508605.3
Canis lupus familiaris (dog)LRP5XP_003432463.1
Bos taurus (cattle)LRP5XP_002699451.1
Mus musculus (house mouse)Lrp5NP_032539.2
Rattus norvegicus (Norway rat)Lrp5NP_001099791.2
Gallus gallus (chicken)LRP5NP_001012915.1
Danio rerio (zebrafish)lrp5NP_001170929.1
Drosophila melanogaster (fruit fly)arrNP_524737.2
GeneCards LRP5
UniProt O75197
MIM 603506
Ensembl ENSG00000162337
HGNC 6697
HPRD 04616

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
low-density lipoprotein receptor-related protein 5
Names
low-density lipoprotein receptor-related protein 5
LRP-5
low density lipoprotein receptor-related protein 7

Interactant



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