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LRP5 low density lipoprotein receptor-related protein 5 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001291902 Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_002335 Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005273994 PREDICTED: Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol LRP5
Entrez Gene ID 4041
Full Name low density lipoprotein receptor-related protein 5
Synonyms BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
General protein information
Preferred Names
low-density lipoprotein receptor-related protein 5
low-density lipoprotein receptor-related protein 5
low density lipoprotein receptor-related protein 7
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

MIM: 603506

Osteoporosis-pseudoglioma syndrome, 259770 (3); [Bone mineral density

mRNA Protein Product Sequence Price Select
NM_001291902, 631790828 NP_001278831, 631790829 low-density lipoprotein receptor-related protein 5 isoform 2 ORF Sequence $1500.00
NM_002335, 631790827 NP_002326, 119709832 low-density lipoprotein receptor-related protein 5 isoform 1 precursor ORF Sequence $2500.00
XM_005273994, 530396779 XP_005274051, 530396780 low-density lipoprotein receptor-related protein 5 isoform X1 ORF Sequence $2500.00
hsa04310Wnt signaling pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP363Wnt Signaling Pathway NetPath
WP399Wnt Signaling Pathway and Pluripotency
Pathway Interaction Database
wnt_signaling_pathwayWnt signaling network
ncadherinpathwayN-cadherin signaling events
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_200777TCF dependent signaling in response to WNT
REACT_200716regulation of FZD by ubiquitination
REACT_200643negative regulation of TCF-dependent signaling by WNT ligand antagonists
REACT_200610disassembly of the destruction complex and recruitment of AXIN to the membrane
Homo sapiens (human)LRP5NP_002326.2
Pan troglodytes (chimpanzee)LRP5XP_508605.3
Canis lupus familiaris (dog)LRP5XP_003432463.2
Bos taurus (cattle)LRP5XP_002699451.2
Mus musculus (house mouse)Lrp5NP_032539.2
Rattus norvegicus (Norway rat)Lrp5NP_001099791.2
Gallus gallus (chicken)LRP5NP_001012915.1
Danio rerio (zebrafish)lrp5NP_001170929.1
Xenopus (Silurana) tropicalis (western clawed frog)lrp5XP_002941689.1
GO:0001702gastrulation with mouth forming secondIBA
GO:0002053positive regulation of mesenchymal cell proliferationIMP
GO:0002076osteoblast developmentIBA
GO:0006007glucose catabolic processIMP
GO:0008203cholesterol metabolic processIEA
GO:0008217regulation of blood pressureIMP
GO:0008284positive regulation of cell proliferationIDA
GO:0009952anterior/posterior pattern specificationIBA
GO:0016055Wnt signaling pathwayIDA
GO:0030326embryonic limb morphogenesisIBA
GO:0033690positive regulation of osteoblast proliferationIEA
GO:0035019somatic stem cell maintenanceIEA
GO:0035426extracellular matrix-cell signalingIEA
GO:0042074cell migration involved in gastrulationIEA
GO:0042632cholesterol homeostasisIMP
GO:0042733embryonic digit morphogenesisIEA
GO:0042981regulation of apoptotic processIEA
GO:0043434response to peptide hormoneIEA
GO:0044332Wnt signaling pathway involved in dorsal/ventral axis specificationIDA
GO:0045600positive regulation of fat cell differentiationIMP
GO:0045668negative regulation of osteoblast differentiationIMP
GO:0045840positive regulation of mitosisIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0046849bone remodelingIBA
GO:0046850regulation of bone remodelingIEA
GO:0048539bone marrow developmentIMP
GO:0048596embryonic camera-type eye morphogenesisIBA
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIEA
GO:0060033anatomical structure regressionIEA
GO:0060042retina morphogenesis in camera-type eyeIMP
GO:0060059embryonic retina morphogenesis in camera-type eyeIBA
GO:0060070canonical Wnt signaling pathwayIDA
GO:0060070canonical Wnt signaling pathwayIMP
GO:0060349bone morphogenesisIMP
GO:0060444branching involved in mammary gland duct morphogenesisIBA
GO:0060612adipose tissue developmentIMP
GO:0060764cell-cell signaling involved in mammary gland developmentIEA
GO:0060828regulation of canonical Wnt signaling pathwayIMP
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulusIBA
GO:0061304retinal blood vessel morphogenesisIMP
GO:0071901negative regulation of protein serine/threonine kinase activityIMP
GO:1902262apoptotic process involved in patterning of blood vesselsIEA
GO:0005783endoplasmic reticulumIEA
GO:0005886plasma membraneIDA
GO:0016021integral component of membraneIEA
GO:0043235receptor complexIDA
GO:0005515protein bindingIPI
GO:0015026coreceptor activityIBA
GO:0017147Wnt-protein bindingIBA
GO:0019534toxin transporter activityIMP
GO:0042813Wnt-activated receptor activityIBA
GeneCards LRP5
UniProt O75197
Vega OTTHUMG00000167570
MIM 603506
Ensembl ENSG00000162337
HGNC 6697
HPRD 04616

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the LRP5 gene?

The LRP5 gene provides instructions for making a protein that is embedded in the outer membrane of many types of cells. It is known as a co-receptor because it works with another receptor protein, frizzled-4 (produced from the FZD4 gene), to transmit chemical signals from outside the cell to the cell's nucleus. Frizzled-4 and the LRP5 protein participate in the Wnt signaling pathway, a series of steps that affect the way cells and tissues develop. Wnt signaling is important for cell division (proliferation), attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities.

The LRP5 protein plays an important role in the development and maintenance of several tissues. During early development, it helps guide the specialization of cells in the retina, which is the light-sensitive tissue at the back of the eye. The LRP5 protein is also involved in establishing a blood supply to the retina and the inner ear. Additionally, this protein helps regulate bone mineral density, which is a measure of the amount of calcium and other minerals in bones. The minerals give the bones strength, making them less likely to break.


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