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SMAD3 SMAD family member 3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19966 NM_005902 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu23553 NM_001145104 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 4, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu23803 NM_001145102 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu23848 NM_001145103 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu48294 XM_006720506 PREDICTED: Homo sapiens SMAD family member 3 (SMAD3), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu19966C NM_005902 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu23553C NM_001145104 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 4, mRNA. Customized vector In-stock 5-7 $149.00
OHu23803C NM_001145102 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu23848C NM_001145103 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu48294C XM_006720506 PREDICTED: Homo sapiens SMAD family member 3 (SMAD3), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol SMAD3
Entrez Gene ID 4088
Full Name SMAD family member 3
Synonyms HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3
General protein information
Preferred Names
mothers against decapentaplegic homolog 3
Names
mothers against decapentaplegic homolog 3
mad3
hMAD-3
hSMAD3
MAD homolog 3
mad homolog JV15-2
mad protein homolog
mothers against DPP homolog 3
SMA- and MAD-related protein 3
SMAD, mothers against DPP homolog 3
MAD, mothers against decapentaplegic homolog 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22.33

Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009].
Disorder

MIM: 603109

mRNA Protein Product Sequence Price Select
NM_001145102, 223029439 NP_001138574, 223029440 mothers against decapentaplegic homolog 3 isoform 2 ORF Sequence $269.00
NM_001145103, 223029441 NP_001138575, 223029442 mothers against decapentaplegic homolog 3 isoform 3 ORF Sequence $400.00
NM_001145104, 223029443 NP_001138576, 223029444 mothers against decapentaplegic homolog 3 isoform 4 ORF Sequence $159.00
NM_005902, 52352808 NP_005893, 5174513 mothers against decapentaplegic homolog 3 isoform 1 ORF Sequence $550.00
XM_006720506, 578826919 XP_006720569, 578826920 mothers against decapentaplegic homolog 3 isoform X1 ORF Sequence $400.00
KEGG
hsa04110Cell cycle
hsa04310Wnt signaling pathway
hsa04520Adherens junction
hsa04350TGF-beta signaling pathway
hsa05212Pancreatic cancer
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05220Chronic myeloid leukemia
hsa04144Endocytosis
hsa05142Chagas disease (American trypanosomiasis)
hsa05166HTLV-I infection
hsa05161Hepatitis B
hsa04390Hippo signaling pathway
hsa05321Inflammatory bowel disease (IBD)
hsa04068FoxO signaling pathway
WikiPathways
WP437EGFR1 Signaling Pathway
WP138Androgen receptor signaling pathway
WP34Ovarian Infertility Genes
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP366TGF-beta Receptor Signaling Pathway
WP615Senescence and Autophagy
WP560TGF Beta Signaling Pathway
WP363Wnt Signaling Pathway NetPath
WP179Cell cycle
WP61Delta-Notch Signaling Pathway
WP710DNA damage response (only ATM dependent)
WP236Adipogenesis
WP53Id Signaling Pathway
WP2324AGE/RAGE pathway
WP1971Integrated Cancer pathway
WP2263Prostate Cancer
Pathway Interaction Database
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
telomerasepathwayRegulation of Telomerase
smad2_3pathwayRegulation of cytoplasmic and nuclear SMAD2/3 signaling
tgfbrpathwayTGF-beta receptor signaling
hif1_tfpathwayHIF-1-alpha transcription factor network
myc_activpathwayValidated targets of C-MYC transcriptional activation
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_111045Developmental Biology
REACT_111102Signal Transduction
REACT_111057Signaling by NODAL
REACT_116125Disease
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_121111Downregulation of SMAD2/3:SMAD4 transcriptional activity
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_150238Signaling by Activin
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
Homo sapiens (human)SMAD3NP_005893.1
Pan troglodytes (chimpanzee)SMAD3XP_001159972.2
Macaca mulatta (Rhesus monkey)SMAD3XP_001111262.1
Canis lupus familiaris (dog)SMAD3NP_001164300.1
Bos taurus (cattle)SMAD3NP_001192734.1
Mus musculus (house mouse)Smad3NP_058049.3
Rattus norvegicus (Norway rat)Smad3NP_037227.1
Gallus gallus (chicken)SMAD3NP_989806.1
Danio rerio (zebrafish)smad3bNP_778258.1
Drosophila melanogaster (fruit fly)SmoxNP_511079.1
Xenopus (Silurana) tropicalis (western clawed frog)smad3NP_001008436.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIMP
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS
GO:0001657ureteric bud developmentIEA
GO:0001666response to hypoxiaIMP
GO:0001701in utero embryonic developmentIEA
GO:0001707mesoderm formationIEA
GO:0001756somitogenesisIEA
GO:0001889liver developmentIEA
GO:0001933negative regulation of protein phosphorylationIMP
GO:0001947heart loopingIEA
GO:0002076osteoblast developmentIEA
GO:0002520immune system developmentIEA
GO:0006351transcription, DNA-templatedTAS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0006810transportIDA
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIMP
GO:0006955immune responseIMP
GO:0007050cell cycle arrestIMP
GO:0007179transforming growth factor beta receptor signaling pathwayIDA
GO:0007179transforming growth factor beta receptor signaling pathwayTAS
GO:0007183SMAD protein complex assemblyIDA
GO:0007492endoderm developmentIEA
GO:0009880embryonic pattern specificationIEA
GO:0010467gene expressionTAS
GO:0010694positive regulation of alkaline phosphatase activityIEA
GO:0010718positive regulation of epithelial to mesenchymal transitionIDA
GO:0010718positive regulation of epithelial to mesenchymal transitionIMP
GO:0016202regulation of striated muscle tissue developmentIEA
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0019049evasion or tolerance of host defenses by virusIDA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0030308negative regulation of cell growthIDA
GO:0030335positive regulation of cell migrationIEA
GO:0030501positive regulation of bone mineralizationIEA
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayTAS
GO:0030878thyroid gland developmentIEA
GO:0031053primary miRNA processingTAS
GO:0032332positive regulation of chondrocyte differentiationIEA
GO:0032731positive regulation of interleukin-1 beta productionIEA
GO:0032909regulation of transforming growth factor beta2 productionIMP
GO:0032916positive regulation of transforming growth factor beta3 productionIEA
GO:0032924activin receptor signaling pathwayIMP
GO:0033689negative regulation of osteoblast proliferationIEA
GO:0035413positive regulation of catenin import into nucleusIMP
GO:0035556intracellular signal transductionIDA
GO:0038092nodal signaling pathwayIMP
GO:0042060wound healingTAS
GO:0042110T cell activationIEA
GO:0042177negative regulation of protein catabolic processIMP
GO:0042993positive regulation of transcription factor import into nucleusIDA
GO:0043066negative regulation of apoptotic processIEA
GO:0045216cell-cell junction organizationIMP
GO:0045668negative regulation of osteoblast differentiationIEA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045930negative regulation of mitotic cell cycleIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterTAS
GO:0048340paraxial mesoderm morphogenesisIEA
GO:0048589developmental growthIEA
GO:0048617embryonic foregut morphogenesisIEA
GO:0048701embryonic cranial skeleton morphogenesisIEA
GO:0050678regulation of epithelial cell proliferationIEA
GO:0050728negative regulation of inflammatory responseIEA
GO:0050776regulation of immune responseIEA
GO:0050821protein stabilizationIMP
GO:0050927positive regulation of positive chemotaxisIEA
GO:0051098regulation of bindingIEA
GO:0051496positive regulation of stress fiber assemblyIEA
GO:0051894positive regulation of focal adhesion assemblyIEA
GO:0060039pericardium developmentIEA
GO:0060290transdifferentiationIEA
GO:0061045negative regulation of wound healingIEA
GO:0070306lens fiber cell differentiationIEA
GO:0090263positive regulation of canonical Wnt signaling pathwayIMP
GO:0097191extrinsic apoptotic signaling pathwayIMP
GO:0097296activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayIEA
GO:1901313positive regulation of gene expression involved in extracellular matrix organizationIMP
Component
IDNameEvidence
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005637nuclear inner membraneIDA
GO:0005654nucleoplasmTAS
GO:0005667transcription factor complexIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005886plasma membraneIEA
GO:0043235receptor complexIMP
GO:0071141SMAD protein complexIDA
GO:0071144SMAD2-SMAD3 protein complexIDA
Function
IDNameEvidence
GO:0000987core promoter proximal region sequence-specific DNA bindingIDA
GO:0000988protein binding transcription factor activityIDA
GO:0001102RNA polymerase II activating transcription factor bindingIPI
GO:0003690double-stranded DNA bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0005160transforming growth factor beta receptor bindingIPI
GO:0005515protein bindingIPI
GO:0005518collagen bindingIEA
GO:0008013beta-catenin bindingIPI
GO:0008134transcription factor bindingIPI
GO:0008270zinc ion bindingIDA
GO:0019901protein kinase bindingIPI
GO:0019902phosphatase bindingIPI
GO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityIDA
GO:0031490chromatin DNA bindingIEA
GO:0031625ubiquitin protein ligase bindingIPI
GO:0035326enhancer bindingIC
GO:0042803protein homodimerization activityIPI
GO:0043130ubiquitin bindingIDA
GO:0043425bHLH transcription factor bindingIPI
GO:0043565sequence-specific DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingIDA
GO:0070410co-SMAD bindingIPI
GO:0070412R-SMAD bindingIPI
GeneCards SMAD3
UniProt Q9P0T0, P84022
Vega OTTHUMG00000133230
MIM 603109
Ensembl ENSG00000166949
HGNC 6769
HPRD 08533

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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