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Sequence in raw or FASTA format:

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SMAD3 SMAD family member 3 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001145102 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 2, mRNA. ORF Sequence $279.27
Peptide Services
Antibody Services
Protein Services
NM_001145103 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 3, mRNA. ORF Sequence $332.34
Peptide Services
Antibody Services
Protein Services
NM_001145104 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 4, mRNA. ORF Sequence $200.97
Peptide Services
Antibody Services
Protein Services
NM_005902 Homo sapiens SMAD family member 3 (SMAD3), transcript variant 1, mRNA. ORF Sequence $370.62
Peptide Services
Antibody Services
Protein Services


Gene Symbol SMAD3
Entrez Gene ID 4088
Full Name SMAD family member 3
Synonyms DKFZp586N0721, DKFZp686J10186, HSPC193, HsT17436, JV15-2, MADH3, MGC60396
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22.33

Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009].
Disorder

MIM: 603109

mRNA Protein Product Sequence Price Select
NM_001145102, 223029439 NP_001138574, 223029440 mothers against decapentaplegic homolog 3 isoform 2 Full Length $2698.65
ORF Sequence $279.27
NM_001145103, 223029441 NP_001138575, 223029442 mothers against decapentaplegic homolog 3 isoform 3 Full Length $2613.60
ORF Sequence $332.34
NM_001145104, 223029443 NP_001138576, 223029444 mothers against decapentaplegic homolog 3 isoform 4 Full Length $2448.45
ORF Sequence $200.97
NM_005902, 52352808 NP_005893, 5174513 mothers against decapentaplegic homolog 3 isoform 1 Full Length $2815.20
ORF Sequence $370.62
KEGG
hsa05166HTLV-I infection
hsa05142Chagas disease (American trypanosomiasis)
hsa04310Wnt signaling pathway
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway
hsa05161Hepatitis B
hsa04520Adherens junction
hsa04144Endocytosis
hsa05220Chronic myeloid leukemia
hsa05210Colorectal cancer
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
WikiPathways
WP2324AGE/RAGE pathway
WP236Adipogenesis
WP437EGFR1 Signaling Pathway
WP138Androgen receptor signaling pathway
WP179Cell cycle
WP61Delta-Notch Signaling Pathway
WP710DNA damage response (only ATM dependent)
WP53Id Signaling Pathway
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP1971Integrated Cancer pathway
WP363Wnt Signaling Pathway NetPath
WP34Ovarian Infertility Genes
WP560TGF Beta Signaling Pathway
WP366TGF-beta Receptor Signaling Pathway
Pathway Interaction Database
smad2_3pathwayRegulation of cytoplasmic and nuclear SMAD2/3 signaling
myc_activpathwayValidated targets of C-MYC transcriptional activation
tgfbrpathwayTGF-beta receptor signaling
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
hif1_tfpathwayHIF-1-alpha transcription factor network
telomerasepathwayRegulation of Telomerase
Reactome
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_111057Signaling by NODAL
REACT_71Gene Expression
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_111102Signal Transduction
REACT_12627Generic Transcription Pathway
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_121111Downregulation of SMAD2/3:SMAD4 transcriptional activity
REACT_111045Developmental Biology
Homo sapiens (human)SMAD3NP_005893.1
Pan troglodytes (chimpanzee)SMAD3XP_001159972.2
Macaca mulatta (Rhesus monkey)SMAD3XP_001111262.1
Canis lupus familiaris (dog)SMAD3NP_001164300.1
Bos taurus (cattle)SMAD3NP_001192734.1
Mus musculus (house mouse)Smad3NP_058049.3
Rattus norvegicus (Norway rat)Smad3NP_037227.1
Gallus gallus (chicken)SMAD3NP_989806.1
Danio rerio (zebrafish)smad3bNP_778258.1
Drosophila melanogaster (fruit fly)SmoxNP_511079.1
GeneCards SMAD3
PDB 1U7F, 1OZJ, 1MHD, 1MJS, 2LAJ, 2LB2, 1MK2
UniProt Q9P0T0, P84022
MIM 603109
Ensembl ENSG00000166949
HGNC 6769
HPRD 08533

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
mothers against decapentaplegic homolog 3
Names
mothers against decapentaplegic homolog 3
mad3
hMAD-3
hSMAD3
MAD homolog 3
mad homolog JV15-2
mad protein homolog
mothers against DPP homolog 3
SMA- and MAD-related protein 3
SMAD, mothers against DPP homolog 3
MAD, mothers against decapentaplegic homolog 3

Interactant

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