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MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18428 NM_005360 Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu31519 NM_001031804 Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18428C NM_005360 Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu31519C NM_001031804 Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol MAF
Entrez Gene ID 4094
Full Name v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
Synonyms CCA4, c-MAF
General protein information
Preferred Names
transcription factor Maf
Names
transcription factor Maf
c-maf proto-oncogene
proto-oncogene c-Maf
T lymphocyte c-maf long form
Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q22-q23

Summary The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
Disorder

MIM: 177075

Cataract, pulverulent or cerulean, with or without microcornea (3)

mRNA Protein Product Sequence Price Select
NM_001031804, 197313769 NP_001026974, 73427806 transcription factor Maf isoform b ORF Sequence $400.00
NM_005360, 197313768 NP_005351, 5453736 transcription factor Maf isoform a ORF Sequence $400.00
KEGG
hsa05202Transcriptional misregulation in cancer
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP3Keap1-Nrf2 Pathway
Pathway Interaction Database
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
cmyb_pathwayC-MYB transcription factor network
Homo sapiens (human)MAFNP_001026974.1
Pan troglodytes (chimpanzee)MAFXP_511123.2
Bos taurus (cattle)MAFNP_001099107.1
Mus musculus (house mouse)MafNP_001020748.2
Rattus norvegicus (Norway rat)MafNP_062191.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001816cytokine productionIEA
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0032330regulation of chondrocyte differentiationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048468cell developmentIEA
GO:0048839inner ear developmentIEA
GO:0070306lens fiber cell differentiationIEA
Component
IDNameEvidence
GO:0000785chromatinTAS
GO:0005634nucleusIEA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards MAF
UniProt O75444
Vega OTTHUMG00000137621
MIM 177075
Ensembl ENSG00000178573
HGNC 6776
HPRD 01518

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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