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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


MAPT microtubule-associated protein tau [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001123066 Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001123067 Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 5, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001203251 Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 7, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001203252 Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 8, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_005910 Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_016834 Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_016835 Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_016841 Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
XM_005257362 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005257364 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005257365 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005257366 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005257367 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005257368 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005257369 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005257370 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005257371 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005257372 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X11, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_005275647 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005275648 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006725265 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725266 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725267 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725268 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725269 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725270 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006725271 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006725272 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X11, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006725273 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X12, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006725274 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X13, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006725275 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X14, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006725616 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X12, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725617 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X13, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725618 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X14, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725619 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X15, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725620 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X16, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006725621 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X17, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006725622 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X18, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006725623 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X19, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006725624 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X20, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006725625 PREDICTED: Homo sapiens microtubule-associated protein tau (MAPT), transcript variant X21, mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

Related Services

Gene Symbol MAPT
Entrez Gene ID 4137
Full Name microtubule-associated protein tau
Synonyms DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
General protein information
Preferred Names
microtubule-associated protein tau
Names
microtubule-associated protein tau
PHF-tau
paired helical filament-tau
neurofibrillary tangle protein
microtubule-associated protein tau, isoform 4
G protein beta1/gamma2 subunit-interacting factor 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21.1

Summary This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].
Disorder

MIM: 157140

Dementia, frontotemporal, with or without parkinsonism, 600274 (3);

mRNA Protein Product Sequence Price Select
NM_001123066, 294862257 NP_001116538, 294862258 microtubule-associated protein tau isoform 6 ORF Sequence $750.00
NM_001123067, 294862254 NP_001116539, 178557736 microtubule-associated protein tau isoform 5 ORF Sequence $269.00
NM_001203251, 322303719 NP_001190180, 322303720 microtubule-associated protein tau isoform 7 ORF Sequence $269.00
NM_001203252, 322303746 NP_001190181, 322303747 microtubule-associated protein tau isoform 8 ORF Sequence $269.00
NM_005910, 294862262 NP_005901, 6754638 microtubule-associated protein tau isoform 2 ORF Sequence $360.00
NM_016834, 294862264 NP_058518, 8400711 microtubule-associated protein tau isoform 3 ORF Sequence $269.00
NM_016835, 294862260 NP_058519, 294862261 microtubule-associated protein tau isoform 1 ORF Sequence $700.00
NM_016841, 294862259 NP_058525, 8400715 microtubule-associated protein tau isoform 4 ORF Sequence $269.00
XM_005257362, 578830934 XP_005257419, 530412219 microtubule-associated protein tau isoform X1 ORF Sequence $750.00
XM_005257364, 578830935 XP_005257421, 530412223 microtubule-associated protein tau isoform X3 ORF Sequence $750.00
XM_005257365, 578830936 XP_005257422, 530412225 microtubule-associated protein tau isoform X4 ORF Sequence $750.00
XM_005257366, 578830937 XP_005257423, 530412227 microtubule-associated protein tau isoform X5 ORF Sequence $750.00
XM_005257367, 578830938 XP_005257424, 530412229 microtubule-associated protein tau isoform X6 ORF Sequence $750.00
XM_005257368, 578830939 XP_005257425, 530412231 microtubule-associated protein tau isoform X7 ORF Sequence $700.00
XM_005257369, 578830940 XP_005257426, 530412233 microtubule-associated protein tau isoform X8 ORF Sequence $550.00
XM_005257370, 578830941 XP_005257427, 530412235 microtubule-associated protein tau isoform X9 ORF Sequence $550.00
XM_005257371, 578830942 XP_005257428, 530412237 microtubule-associated protein tau isoform X10 ORF Sequence $550.00
XM_005257372, 578841193 XP_005257429, 578841194 microtubule-associated protein tau isoform X11 ORF Sequence $400.00
XM_005275647, 530429799 XP_005275704, 530429800 microtubule-associated protein tau isoform X2 ORF Sequence $550.00
XM_005275648, 578840200 XP_005275705, 530429802 microtubule-associated protein tau isoform X3 ORF Sequence $400.00
XM_006725265, 578840182 XP_006725328, 578840183 microtubule-associated protein tau isoform X4 ORF Sequence $750.00
XM_006725266, 578840184 XP_006725329, 578840185 microtubule-associated protein tau isoform X5 ORF Sequence $750.00
XM_006725267, 578840186 XP_006725330, 578840187 microtubule-associated protein tau isoform X6 ORF Sequence $750.00
XM_006725268, 578840188 XP_006725331, 578840189 microtubule-associated protein tau isoform X7 ORF Sequence $750.00
XM_006725269, 578840190 XP_006725332, 578840191 microtubule-associated protein tau isoform X8 ORF Sequence $750.00
XM_006725270, 578840192 XP_006725333, 578840193 microtubule-associated protein tau isoform X9 ORF Sequence $550.00
XM_006725271, 578840194 XP_006725334, 578840195 microtubule-associated protein tau isoform X10 ORF Sequence $550.00
XM_006725272, 578840196 XP_006725335, 578840197 microtubule-associated protein tau isoform X11 ORF Sequence $550.00
XM_006725273, 578840198 XP_006725336, 578840199 microtubule-associated protein tau isoform X12 ORF Sequence $400.00
XM_006725274, 578840201 XP_006725337, 578840202 microtubule-associated protein tau isoform X13 ORF Sequence $400.00
XM_006725275, 578840203 XP_006725338, 578840204 microtubule-associated protein tau isoform X14 ORF Sequence $400.00
XM_006725616, 578841175 XP_006725679, 578841176 microtubule-associated protein tau isoform X12 ORF Sequence $750.00
XM_006725617, 578841177 XP_006725680, 578841178 microtubule-associated protein tau isoform X13 ORF Sequence $750.00
XM_006725618, 578841179 XP_006725681, 578841180 microtubule-associated protein tau isoform X14 ORF Sequence $750.00
XM_006725619, 578841181 XP_006725682, 578841182 microtubule-associated protein tau isoform X15 ORF Sequence $750.00
XM_006725620, 578841183 XP_006725683, 578841184 microtubule-associated protein tau isoform X16 ORF Sequence $750.00
XM_006725621, 578841185 XP_006725684, 578841186 microtubule-associated protein tau isoform X17 ORF Sequence $700.00
XM_006725622, 578841187 XP_006725685, 578841188 microtubule-associated protein tau isoform X18 ORF Sequence $550.00
XM_006725623, 578841189 XP_006725686, 578841190 microtubule-associated protein tau isoform X19 ORF Sequence $550.00
XM_006725624, 578841191 XP_006725687, 578841192 microtubule-associated protein tau isoform X20 ORF Sequence $550.00
XM_006725625, 578841195 XP_006725688, 578841196 microtubule-associated protein tau isoform X21 ORF Sequence $400.00
KEGG
hsa04010MAPK signaling pathway
hsa05010Alzheimer's disease
WikiPathways
WP382MAPK signaling pathway
WP49IL-2 Signaling pathway
WP364IL-6 Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2380BDNF signaling pathway
WP2059Alzheimers Disease
WP2038Regulation of Microtubule Cytoskeleton
Pathway Interaction Database
lysophospholipid_pathwayLPA receptor mediated events
reelinpathwayReelin signaling pathway
Reactome
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_13541Caspase-mediated cleavage of cytoskeletal proteins
REACT_995Apoptotic execution phase
Homo sapiens (human)MAPTNP_001116538.2
Pan troglodytes (chimpanzee)MAPTNP_001009068.1
Macaca mulatta (Rhesus monkey)MAPTXP_002800599.1
Canis lupus familiaris (dog)MAPTNP_001104271.1
Bos taurus (cattle)MAPTNP_776531.1
Mus musculus (house mouse)MaptNP_001033698.1
Rattus norvegicus (Norway rat)MaptNP_058908.2
Gallus gallus (chicken)MAPTNP_001186122.1
Xenopus (Silurana) tropicalis (western clawed frog)maptNP_001072465.1
Process
IDNameEvidence
GO:0000226microtubule cytoskeleton organizationIDA
GO:0001764neuron migrationIEA
GO:0006915apoptotic processTAS
GO:0006921cellular component disassembly involved in execution phase of apoptosisTAS
GO:0007628adult walking behaviorIEA
GO:0008088axon cargo transportIEA
GO:0010506regulation of autophagyIGI
GO:0031113regulation of microtubule polymerizationNAS
GO:0031116positive regulation of microtubule polymerizationIDA
GO:0032387negative regulation of intracellular transportIEA
GO:0045773positive regulation of axon extensionIDA
GO:0047497mitochondrion transport along microtubuleIEA
GO:0048675axon extensionIEA
GO:0048699generation of neuronsNAS
GO:0060632regulation of microtubule-based movementIEA
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0005874microtubuleIEA
GO:0005875microtubule associated complexTAS
GO:0005886plasma membraneIDA
GO:0030424axonIDA
GO:0030426growth coneIDA
GO:0034399nuclear peripheryIDA
GO:0036464cytoplasmic ribonucleoprotein granuleIDA
GO:0045298tubulin complexIDA
Function
IDNameEvidence
GO:0005200structural constituent of cytoskeletonTAS
GO:0005515protein bindingIPI
GO:0008017microtubule bindingIDA
GO:0017124SH3 domain bindingIPI
GO:0019899enzyme bindingIPI
GO:0019901protein kinase bindingIEA
GO:0034185apolipoprotein bindingIPI
GO:0071813lipoprotein particle bindingIPI
GeneCards MAPT
UniProt B3KTM0, P10636
Vega OTTHUMG00000168833
MIM 157140
Ensembl ENSG00000186868
HGNC 6893
HPRD 01142

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the MAPT gene?

The MAPT gene provides instructions for making a protein called tau. This protein is found throughout the nervous system, including in nerve cells (neurons) in the brain. It is involved in assembling and stabilizing microtubules, which are rigid, hollow fibers that make up the cell's structural framework (the cytoskeleton). Microtubules help cells maintain their shape, assist in the process of cell division, and are essential for the transport of materials within cells.

Six different versions (isoforms) of the tau protein are produced in the adult brain. The isoforms vary in length from 352 to 441 protein building blocks (amino acids). A region of the protein called the microtubule-binding domain, which is the part of the protein that attaches (binds) to microtubules, also varies among the isoforms. In three of the isoforms, the microtubule-binding domain contains three repeated segments. In the other three isoforms, this domain contains four repeated segments. Typically, the brain has approximately the same amount of three-repeat isoforms and four-repeat isoforms. This balance appears to be essential for the normal function of neurons.

Interactant

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