Sequence in raw or FASTA format:
MAS1 MAS1 proto-oncogene, G protein-coupled receptor [
Homo sapiens (human)]
Gene Symbol MAS1
Entrez Gene ID
Full Name MAS1 proto-oncogene, G protein-coupled receptor
Synonyms MAS, MGRA
General protein information
Gene Type protein-coding
Homo sapiens (human)
Chromosome:6 Map Location:6q25.3-q26
Summary This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012].
hsa04080 Neuroactive ligand-receptor interaction
hsa04614 Renin-angiotensin system
WP554 ACE Inhibitor Pathway
WP455 GPCRs, Class A Rhodopsin-like
Related articles in PubMed Angiotensin-(1-7)-mediated signaling in cardiomyocytes. Gomes ER, et al. Int J Hypertens, 2012. PMID 22518286. Angiotensin converting enzyme 2, Angiotensin-(1-7), and receptor MAS axis in the kidney. Pinheiro SV, et al. Int J Hypertens, 2012. PMID 22518283. Therapeutic targeting of the angiotensin-converting enzyme 2/Angiotensin-(1-7)/Mas cascade in the renin-angiotensin system: a patent review. Ferreira AJ, et al. Expert Opin Ther Pat, 2012 May. PMID 22510001. New cardiovascular and pulmonary therapeutic strategies based on the Angiotensin-converting enzyme 2/angiotensin-(1-7)/mas receptor axis. Ferreira AJ, et al. Int J Hypertens, 2012. PMID 22319643. Biosynthetic pathways and the role of the MAS receptor in the effects of Angiotensin-(1-7) in smooth muscles. Fressatto de Godoy MA, et al. Int J Hypertens, 2012. PMID 22164327. See all (30) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
MasR was significantly upregulated in colon adenocarcinoma compared with non-neoplastic colon mucosa, which showed little or no expression of it. ACE gene expression and enzymatic activity were also increased in the tumors.
Title: Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma.
Activation of Mas during myocardial infarction contributes to ischemia-reperfusion injury and suggest that inhibition of Mas-G(q) signaling may provide a new therapeutic strategy directed at cardioprotection.
Title: Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection.
Report expression (pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis.
Title: (Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis.
Angiotensin-(1-7), its receptor Mas, and ACE2 are expressed in the human ovary
Title: Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary.
The immunolocalization of Ang-(1-7) and its receptor Mas in testes of fertile and infertile men suggests that this system may be altered when spermatogenesis is severely impaired.
Title: Angiotensin (1-7) and its receptor Mas are expressed in the human testis: implications for male infertility.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Interactions among related genes of renin-angiotensin system associated with type 2 diabetes.
the Mas oncogene acts as a receptor for Angiotensin (1-7)--REVIEW
Title: Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis.
Mas, MrgD, and MRG mediated Ang IV-stimulated AA release that was highest for Mas. While Ang III activated Mas and MrgX2, Ang II stimulated AA release via Mas and MRG.
Title: Angiotensin metabolites can stimulate receptors of the Mas-related genes family.
The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium.
Title: The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium.
Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
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