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MAS1 MAS1 proto-oncogene, G protein-coupled receptor [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002377 Homo sapiens MAS1 proto-oncogene, G protein-coupled receptor (MAS1), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Gene Symbol MAS1
Entrez Gene ID 4142
Full Name MAS1 proto-oncogene, G protein-coupled receptor
Synonyms MAS, MGRA
General protein information
Preferred Names
proto-oncogene Mas
Names
proto-oncogene Mas
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q25.3-q26

Summary This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012].
Disorder

MIM: 165180

mRNA Protein Product Sequence Price Select
NM_002377, 6006022 NP_002368, 4505105 proto-oncogene Mas ORF Sequence $269.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04614Renin-angiotensin system
WikiPathways
WP554ACE Inhibitor Pathway
WP455GPCRs, Class A Rhodopsin-like
Homo sapiens (human)MAS1NP_002368.1
Pan troglodytes (chimpanzee)MAS1XP_527553.1
Macaca mulatta (Rhesus monkey)MAS1XP_001098523.1
Canis lupus familiaris (dog)MAS1XP_005615616.1
Bos taurus (cattle)MAS1XP_002690422.1
Mus musculus (house mouse)Mas1NP_032578.2
Rattus norvegicus (Norway rat)Mas1NP_036889.1
Gallus gallus (chicken)MAS1XP_426151.2
Xenopus (Silurana) tropicalis (western clawed frog)LOC100494761XP_002938917.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100492282XP_002936476.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100492615XP_002936478.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100492446XP_002936477.1
Process
IDNameEvidence
GO:0001933negative regulation of protein phosphorylationIEA
GO:0007186G-protein coupled receptor signaling pathwayTAS
GO:0007250activation of NF-kappaB-inducing kinase activityIEA
GO:0007283spermatogenesisIEA
GO:0008283cell proliferationTAS
GO:0008284positive regulation of cell proliferationIEA
GO:0008584male gonad developmentIEA
GO:0009653anatomical structure morphogenesisTAS
GO:0014823response to activityIEA
GO:0021766hippocampus developmentIEA
GO:0034698response to gonadotropinIEA
GO:0038166angiotensin-activated signaling pathwayIEA
GO:0042493response to drugIEA
GO:0045740positive regulation of DNA replicationIEA
GO:0050727regulation of inflammatory responseIEA
GO:0060732positive regulation of inositol phosphate biosynthetic processIEA
GO:0070528protein kinase C signalingIMP
GO:0071375cellular response to peptide hormone stimulusIEA
Component
IDNameEvidence
GO:0005886plasma membraneIDA
GO:0005887integral component of plasma membraneTAS
GO:0009986cell surfaceIEA
Function
IDNameEvidence
GO:0001595angiotensin receptor activityISS
GO:0004930G-protein coupled receptor activityIDA
GO:0004945angiotensin type II receptor activityTAS
GO:0017046peptide hormone bindingIEA
GO:0042277peptide bindingISS
GeneCards MAS1
UniProt W8W3P4, P04201
Vega OTTHUMG00000015944
MIM 165180
Ensembl ENSG00000130368
HGNC 6899
HPRD 01306

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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