MBL2 mannose-binding lectin (protein C) 2, soluble [Homo sapiens (human)]
| Gene Symbol | MBL2 |
| Entrez Gene ID | 4153 |
| Full Name | mannose-binding lectin (protein C) 2, soluble |
| Synonyms | COLEC1, HSMBPC, MBL, MBP, MBP1, MGC116832, MGC116833 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
10 10q11.2 |
| Summary | This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq]. |
| Disorder | MIM: 154545 Mannose-binding protein deficiency (3); {Diabetes mellitus, |
| mRNA | NM_000242, 171906615 |
| Protein | NP_000233, 4557739 |
| Product | mannose-binding protein C precursor |
| RefSeq Status | REVIEWED |
| hsa04145 | Phagosome |
| hsa05150 | Staphylococcus aureus infection |
| hsa04610 | Complement and coagulation cascades |
Reactome
| REACT_8024 | Initial triggering of complement |
| REACT_6802 | Innate Immunity Signaling |
| REACT_6900 | Signaling in Immune system |
| REACT_7964 | Lectin pathway of complement activation |
| REACT_6932 | Complement cascade |
| REACT_8012 | Creation of C4 and C2 activators |
| Homo sapiens (human) | MBL2 | NP_000233.1 |
| Pan troglodytes (chimpanzee) | MBL2 | NP_001009005.1 |
| Bos taurus (cattle) | MBL2 | NP_776532.1 |
| Mus musculus (house mouse) | Mbl2 | NP_034906.1 |
| Rattus norvegicus (Norway rat) | Mbl2 | NP_073195.1 |
| Gallus gallus (chicken) | MBL2 | NP_989680.1 |
| Danio rerio (zebrafish) | hbl3 | NP_571645.2 |
| Danio rerio (zebrafish) | hbl4 | NP_001108197.1 |
| Danio rerio (zebrafish) | hbl1 | XP_001341915.1 |
| Danio rerio (zebrafish) | LOC566971 | XP_695347.1 |
| ID | Name | Evidence |
| GO:0001867 | complement activation, lectin pathway | EXP |
| GO:0001867 | complement activation, lectin pathway | IDA |
| GO:0001867 | complement activation, lectin pathway | IPI |
| GO:0006953 | acute-phase response | TAS |
| GO:0006956 | complement activation | TAS |
| GO:0006958 | complement activation, classical pathway | IEA |
| GO:0006979 | response to oxidative stress | NAS |
| GO:0008228 | opsonization | TAS |
| GO:0044130 | negative regulation of growth of symbiont in host | IDA |
| GO:0045087 | innate immune response | TAS |
| GO:0050766 | positive regulation of phagocytosis | IEA |
| GO:0050830 | defense response to Gram-positive bacterium | IDA |
| GO:0051873 | killing by host of symbiont cells | IEA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | EXP |
| GO:0005576 | extracellular region | TAS |
| GO:0005581 | collagen | IEA |
| GO:0005615 | extracellular space | IEA |
Function
| ID | Name | Evidence |
| GO:0005102 | receptor binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0005529 | sugar binding | IEA |
| GO:0005537 | mannose binding | NAS |
| GO:0005537 | mannose binding | TAS |
| GO:0043499 | eukaryotic cell surface binding | TAS |
| GO:0043621 | protein self-association | IEA |
| GO:0048306 | calcium-dependent protein binding | IPI |
| GO:0051635 | bacterial cell surface binding | TAS |
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