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MBL2 mannose-binding lectin (protein C) 2, soluble [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000242 Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
XM_005269844 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006717860 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006717861 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006717862 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $299.00 14

*Business Day

Related Services

Gene Symbol MBL2
Entrez Gene ID 4153
Full Name mannose-binding lectin (protein C) 2, soluble
Synonyms COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD
General protein information
Preferred Names
mannose-binding protein C
Names
mannose-binding protein C
collectin-1
mannan-binding lectin
mannose-binding lectin 2, soluble (opsonic defect)
mannose-binding lectin (protein C) 2, soluble (opsonic defect)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q11.2

Summary This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008].
Disorder

MIM: 154545

Mannose-binding protein deficiency (3); {Diabetes mellitus,

mRNA Protein Product Sequence Price Select
NM_000242, 171906615 NP_000233, 4557739 mannose-binding protein C precursor ORF Sequence $159.00
XM_005269844, 578819484 XP_005269901, 578819485 mannose-binding protein C isoform X1 ORF Sequence $300.00
XM_006717860, 578819482 XP_006717923, 578819483 mannose-binding protein C isoform X2 ORF Sequence $300.00
XM_006717861, 578819486 XP_006717924, 578819487 mannose-binding protein C isoform X3 ORF Sequence $250.00
XM_006717862, 578819488 XP_006717925, 578819489 mannose-binding protein C isoform X4 ORF Sequence $150.00
KEGG
hsa04610Complement and coagulation cascades
hsa04145Phagosome
hsa05150Staphylococcus aureus infection
Reactome
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_6932Complement cascade
REACT_8012Creation of C4 and C2 activators
REACT_8024Initial triggering of complement
REACT_7964Lectin pathway of complement activation
Homo sapiens (human)MBL2NP_000233.1
Pan troglodytes (chimpanzee)MBL2NP_001009005.1
Macaca mulatta (Rhesus monkey)MBL2NP_001099005.1
Bos taurus (cattle)MBL2NP_776532.1
Mus musculus (house mouse)Mbl2NP_034906.1
Rattus norvegicus (Norway rat)Mbl2NP_073195.2
Rattus norvegicus (Norway rat)LOC100911854XP_003749136.1
Gallus gallus (chicken)MBL2NP_989680.2
Danio rerio (zebrafish)hbl3NP_571645.2
Danio rerio (zebrafish)hbl4NP_001108197.1
Danio rerio (zebrafish)hbl1XP_001341915.1
Danio rerio (zebrafish)hbl2XP_695347.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100496214XP_002933943.1
Process
IDNameEvidence
GO:0001867complement activation, lectin pathwayIDA
GO:0001867complement activation, lectin pathwayIPI
GO:0001867complement activation, lectin pathwayTAS
GO:0006953acute-phase responseTAS
GO:0006956complement activationTAS
GO:0006958complement activation, classical pathwayIEA
GO:0006979response to oxidative stressNAS
GO:0008228opsonizationTAS
GO:0042742defense response to bacteriumTAS
GO:0044130negative regulation of growth of symbiont in hostIDA
GO:0045087innate immune responseIDA
GO:0045087innate immune responseTAS
GO:0048525negative regulation of viral processIDA
GO:0050766positive regulation of phagocytosisIEA
GO:0050830defense response to Gram-positive bacteriumIDA
GO:0051873killing by host of symbiont cellsIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005581collagen trimerIEA
GO:0005615extracellular spaceIDA
GO:0009986cell surfaceTAS
Function
IDNameEvidence
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GO:0005537mannose bindingIDA
GO:0005537mannose bindingNAS
GO:0005537mannose bindingTAS
GO:0048306calcium-dependent protein bindingIPI
GeneCards MBL2
PDB 1HUP
UniProt P11226, Q5SQS3
Vega OTTHUMG00000150270
MIM 154545
Ensembl ENSG00000165471
HGNC 6922
HPRD 01107

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the MBL2 gene?

The MBL2 gene provides instructions for making a protein that assembles into a protein complex called mannose-binding lectin. Functional mannose-binding lectins are made up of two to six protein groups called trimers, which are each composed of three of the protein pieces (subunits) produced from the MBL2 gene. This protein complex plays an important role in the immune system's response to foreign invaders (pathogens).

Mannose-binding lectin recognizes and attaches (binds) to sugars, such as mannose, fucose, and glucose, that are found on the surface of bacteria, viruses, and yeast. This binding turns on (activates) the complement system, which is a group of immune system proteins that work together to destroy pathogens, trigger inflammation, and remove debris from cells and tissues. Attachment of mannose-binding lectin also targets the pathogen to be engulfed and broken down by special immune cells. Recognition of foreign invaders by mannose-binding lectin provides one of the body's first lines of defense against infection.

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