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MBL2 mannose-binding lectin (protein C) 2, soluble [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19370 NM_000242 Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu44346 XM_006717860 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu44346 XM_005269844 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu19370 XM_006717861 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu44347 XM_006717862 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu19370C NM_000242 Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), mRNA. Customized vector In-stock 5-7 $149.00
OHu44346C XM_006717860 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu44346C XM_005269844 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu19370C XM_006717861 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X3, mRNA. Customized vector On-demand 7-9 $209.00
OHu44347C XM_006717862 PREDICTED: Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), transcript variant X4, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol MBL2
Entrez Gene ID 4153
Full Name mannose-binding lectin (protein C) 2, soluble
Synonyms COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD
General protein information
Preferred Names
mannose-binding protein C
Names
mannose-binding protein C
collectin-1
mannan-binding lectin
mannose-binding lectin 2, soluble (opsonic defect)
mannose-binding lectin (protein C) 2, soluble (opsonic defect)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q11.2

Summary This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008].
Disorder

MIM: 154545

Mannose-binding protein deficiency (3); {Diabetes mellitus,

mRNA Protein Product Sequence Price Select
NM_000242, 171906615 NP_000233, 4557739 mannose-binding protein C precursor ORF Sequence $159.00
XM_005269844, 578819484 XP_005269901, 578819485 mannose-binding protein C isoform X1 ORF Sequence $300.00
XM_006717860, 578819482 XP_006717923, 578819483 mannose-binding protein C isoform X2 ORF Sequence $300.00
XM_006717861, 578819486 XP_006717924, 578819487 mannose-binding protein C isoform X3 ORF Sequence $250.00
XM_006717862, 578819488 XP_006717925, 578819489 mannose-binding protein C isoform X4 ORF Sequence $150.00
KEGG
hsa04610Complement and coagulation cascades
hsa04145Phagosome
hsa05150Staphylococcus aureus infection
Reactome
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_6932Complement cascade
REACT_8012Creation of C4 and C2 activators
REACT_8024Initial triggering of complement
REACT_7964Lectin pathway of complement activation
Homo sapiens (human)MBL2NP_000233.1
Pan troglodytes (chimpanzee)MBL2NP_001009005.1
Macaca mulatta (Rhesus monkey)MBL2NP_001099005.1
Bos taurus (cattle)MBL2NP_776532.1
Mus musculus (house mouse)Mbl2NP_034906.1
Rattus norvegicus (Norway rat)Mbl2NP_073195.2
Rattus norvegicus (Norway rat)LOC100911854XP_003749136.1
Gallus gallus (chicken)MBL2NP_989680.2
Danio rerio (zebrafish)hbl3NP_571645.2
Danio rerio (zebrafish)hbl4NP_001108197.1
Danio rerio (zebrafish)hbl1XP_001341915.1
Danio rerio (zebrafish)hbl2XP_695347.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100496214XP_002933943.1
Process
IDNameEvidence
GO:0001867complement activation, lectin pathwayIDA
GO:0001867complement activation, lectin pathwayIPI
GO:0001867complement activation, lectin pathwayTAS
GO:0006953acute-phase responseTAS
GO:0006956complement activationTAS
GO:0006958complement activation, classical pathwayIEA
GO:0006979response to oxidative stressNAS
GO:0008228opsonizationTAS
GO:0042742defense response to bacteriumTAS
GO:0044130negative regulation of growth of symbiont in hostIDA
GO:0045087innate immune responseIDA
GO:0045087innate immune responseTAS
GO:0048525negative regulation of viral processIDA
GO:0050766positive regulation of phagocytosisIEA
GO:0050830defense response to Gram-positive bacteriumIDA
GO:0051873killing by host of symbiont cellsIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005581collagen trimerIEA
GO:0005615extracellular spaceIDA
GO:0009986cell surfaceTAS
Function
IDNameEvidence
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GO:0005537mannose bindingIDA
GO:0005537mannose bindingNAS
GO:0005537mannose bindingTAS
GO:0048306calcium-dependent protein bindingIPI
GeneCards MBL2
PDB 1HUP
UniProt P11226, Q5SQS3
Vega OTTHUMG00000150270
MIM 154545
Ensembl ENSG00000165471
HGNC 6922
HPRD 01107

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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