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MBL2 mannose-binding lectin (protein C) 2, soluble [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000242 Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), mRNA. ORF Sequence $216.63
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Gene Symbol MBL2
Entrez Gene ID 4153
Full Name mannose-binding lectin (protein C) 2, soluble
Synonyms COLEC1, HSMBPC, MBL, MBP, MBP1, MGC116832, MGC116833
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q11.2

Summary This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008].
Disorder

MIM: 154545

Mannose-binding protein deficiency (3); {Diabetes mellitus,

mRNA Protein Product Sequence Price Select
NM_000242, 171906615 NP_000233, 4557739 mannose-binding protein C precursor Full Length $1249.15
ORF Sequence $216.63
KEGG
hsa04145Phagosome
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
Reactome
REACT_6932Complement cascade
REACT_8012Creation of C4 and C2 activators
REACT_7964Lectin pathway of complement activation
REACT_8024Initial triggering of complement
REACT_6802Innate Immune System
REACT_6900Immune System
Homo sapiens (human)MBL2NP_000233.1
Pan troglodytes (chimpanzee)MBL2NP_001009005.1
Macaca mulatta (Rhesus monkey)MBL2NP_001099005.1
Bos taurus (cattle)MBL2NP_776532.1
Mus musculus (house mouse)Mbl2NP_034906.1
Rattus norvegicus (Norway rat)Mbl2NP_073195.2
Gallus gallus (chicken)MBL2NP_989680.2
Danio rerio (zebrafish)hbl3NP_571645.2
Danio rerio (zebrafish)hbl4NP_001108197.1
Danio rerio (zebrafish)hbl1XP_001341915.1
Danio rerio (zebrafish)LOC566971XP_695347.1
GeneCards MBL2
PDB 1HUP
UniProt P11226, Q5SQS3
MIM 154545
Ensembl ENSG00000165471
HGNC 6922
HPRD 01107

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
mannose-binding protein C
Names
mannose-binding protein C
collectin-1
mannan-binding lectin
mannose-binding lectin 2, soluble (opsonic defect)
mannose-binding lectin (protein C) 2, soluble (opsonic defect)

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