• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25891 NM_002415 Homo sapiens macrophage migration inhibitory factor (glycosylation-inhibiting factor) (MIF), mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu25891C NM_002415 Homo sapiens macrophage migration inhibitory factor (glycosylation-inhibiting factor) (MIF), mRNA. Customized vector On-demand 7-9 $209.00

*Business Day

Related Services

Gene Symbol MIF
Entrez Gene ID 4282
Full Name macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Synonyms GIF, GLIF, MMIF
General protein information
Preferred Names
macrophage migration inhibitory factor
Names
macrophage migration inhibitory factor
L-dopachrome isomerase
L-dopachrome tautomerase
phenylpyruvate tautomerase
NP_002406.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q11.23

Summary This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008].
Disorder

MIM: 153620

{Rheumatoid arthritis, systemic juvenile, susceptibility to},

mRNA Protein Product Sequence Price Select
NM_002415, 4505184 NP_002406, 4505185 macrophage migration inhibitory factor ORF Sequence $150.00
KEGG
hsa00350Tyrosine metabolism
hsa00360Phenylalanine metabolism
WikiPathways
WP236Adipogenesis
WP2431Spinal Cord Injury
Homo sapiens (human)MIFNP_002406.1
Macaca mulatta (Rhesus monkey)MIFNP_001028087.1
Bos taurus (cattle)MIFNP_001028780.1
Mus musculus (house mouse)MifNP_034928.1
Rattus norvegicus (Norway rat)MifNP_112313.1
Gallus gallus (chicken)MIFXP_003642282.1
Danio rerio (zebrafish)mifNP_001036786.1
Xenopus (Silurana) tropicalis (western clawed frog)mifNP_001107147.1
Process
IDNameEvidence
GO:0001516prostaglandin biosynthetic processIDA
GO:0002906negative regulation of mature B cell apoptotic processIEA
GO:0006954inflammatory responseIEA
GO:0007166cell surface receptor signaling pathwayIDA
GO:0007569cell agingIEA
GO:0008283cell proliferationIDA
GO:0010629negative regulation of gene expressionIDA
GO:0010739positive regulation of protein kinase A signalingIDA
GO:0019752carboxylic acid metabolic processIDA
GO:0030330DNA damage response, signal transduction by p53 class mediatorIEA
GO:0030890positive regulation of B cell proliferationIDA
GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathwayIEA
GO:0032269negative regulation of cellular protein metabolic processIEA
GO:0033033negative regulation of myeloid cell apoptotic processIEA
GO:0033138positive regulation of peptidyl-serine phosphorylationIDA
GO:0042327positive regulation of phosphorylationIDA
GO:0043030regulation of macrophage activationNAS
GO:0043066negative regulation of apoptotic processIDA
GO:0043406positive regulation of MAP kinase activityIEA
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediatorIDA
GO:0045087innate immune responseIEA
GO:0048146positive regulation of fibroblast proliferationIDA
GO:0050715positive regulation of cytokine secretionIDA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA
GO:0050918positive chemotaxisIDA
GO:0061078positive regulation of prostaglandin secretion involved in immune responseIEA
GO:0061081positive regulation of myeloid leukocyte cytokine production involved in immune responseIEA
GO:0070207protein homotrimerizationIPI
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0071157negative regulation of cell cycle arrestIDA
GO:0090238positive regulation of arachidonic acid secretionIEA
GO:0090344negative regulation of cell agingIDA
GO:1902166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIDA
GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 productionIEA
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005615extracellular spaceIEA
GO:0005737cytoplasmIEA
GO:0009986cell surfaceIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004167dopachrome isomerase activityIDA
GO:0005102receptor bindingIPI
GO:0005125cytokine activityIDA
GO:0005126cytokine receptor bindingIPI
GO:0005515protein bindingIPI
GO:0042056chemoattractant activityIDA
GO:0050178phenylpyruvate tautomerase activityIDA

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.