Sequence in raw or FASTA format:
CXCL9 chemokine (C-X-C motif) ligand 9 [
Homo sapiens (human)]
Gene Symbol CXCL9
Entrez Gene ID
Full Name chemokine (C-X-C motif) ligand 9
Synonyms CMK, Humig, MIG, SCYB9, crg-10
General protein information
C-X-C motif chemokine 9
C-X-C motif chemokine 9
small-inducible cytokine B9
monokine induced by gamma interferon
monokine induced by interferon-gamma
Gene Type protein-coding
Homo sapiens (human)
Chromosome:4 Map Location:4q21
Summary The function of this gene has not been specifically defined; however, it is thought to be involved in T cell trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of cytokines. [provided by RefSeq, Jul 2008].
hsa04060 Cytokine-cytokine receptor interaction
hsa04620 Toll-like receptor signaling pathway
hsa04062 Chemokine signaling pathway
WP619 Type II interferon signaling (IFNG)
WP75 Toll-like receptor signaling pathway
WP1449 Regulation of toll-like receptor signaling pathway
Pathway Interaction Database
Related articles in PubMed Expression of CXCR3 and its ligands CXCL9, -10 and -11 in paediatric opsoclonus-myoclonus syndrome. Pranzatelli MR, et al. Clin Exp Immunol, 2013 Jun. PMID 23600831. Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy. Nawaz MI, et al. Exp Eye Res, 2013 Apr. PMID 23352833. Bortezomib regulates the chemotactic characteristics of T cells through downregulation of CXCR3/CXCL9 expression and induction of apoptosis. Liu W, et al. Int J Hematol, 2012 Dec. PMID 23179902. Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10. Nogueira LG, et al. PLoS Negl Trop Dis, 2012. PMID 23150742. Chemokine-mediated tissue recruitment of CXCR3+ CD4+ T cells plays a major role in the pathogenesis of chronic GVHD. Croudace JE, et al. Blood, 2012 Nov 15. PMID 23012327. See all (110) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
CXCR3 ligands CXCL10, CXCL9 and CXCL11 were measured in 245 children with opsoclonus-myoclonus syndrome and 81 controls.
Title: Expression of CXCR3 and its ligands CXCL9, -10 and -11 in paediatric opsoclonus-myoclonus syndrome.
This study aimed at examining the presence and role of chemokines (angiogenic CCL2/MCP-1 and angiostatic CXCL4/PF-4, CXCL9/Mig, CXCL10/IP-10) in proliferative diabetic retinopathy.
Title: Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy.
The secretion of CXCL9 by activated T cells is also increasingly downregulated with increasing concentrations of bortezomib.
Title: Bortezomib regulates the chemotactic characteristics of T cells through downregulation of CXCR3/CXCL9 expression and induction of apoptosis.
Report high serum levels of CXCL9/TNF-alpha/interferon-gamma in patients with mixed cryoglobulinaemia and chronic hepatitis C.
Title: Chemokine (CXC motif) ligand 9 serum levels in mixed cryoglobulinaemia are associated with circulating levels of IFN-gamma and TNF-alpha.
Expression of CXCL9, -10, and -11 chemokines and their receptor CXCR3 increases in the aqueous humor of patients with herpetic endotheliitis.
Title: Expression of CXCL9, -10, and -11 in the aqueous humor of patients with herpetic endotheliitis.
Intragraft CXCL9 mRNA has a functionally important role in T-cell activation in liver allograft and serves as biomarker for acute cellular rejection.
Title: Intragraft transcriptome level of CXCL9 as biomarker of acute cellular rejection after liver transplantation.
These results may suggest that CXCL9 and CXCL10 are master regulators of myocardial inflammatory cell migration, perhaps affecting clinical progression to the life-threatening form of chronic Chagas cardiomyopathy.
Title: Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10.
CXCL9/10 have antifibrotic roles on liver non-parenchymal cells
Title: Gene profile of chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9/10 on liver non-parenchymal cells.
CXCL9 is localized predominantly in the cytoplasm of breast cancer cells and prostaglandin E2 inhibits cytokine induced CXCL9 secretion.
Title: Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer.
In chronic graft-vs-host disease, increased levels of the Th1-associated chemokines CXCL9, CXCL10, and CXCL11 led to recruitment of CXCR3+ T cells from the peripheral blood into affected tissues.
Title: Chemokine-mediated tissue recruitment of CXCR3+ CD4+ T cells plays a major role in the pathogenesis of chronic GVHD.
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