CXCL9 chemokine (C-X-C motif) ligand 9 [Homo sapiens (human)]
| Gene Symbol | CXCL9 |
| Entrez Gene ID | 4283 |
| Full Name | chemokine (C-X-C motif) ligand 9 |
| Synonyms | CMK, Humig, MIG, SCYB9, crg-10 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
4 4q21 |
| Summary | The function of this gene has not been specifically defined; however, it is thought to be involved in T cell trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of cytokines. [provided by RefSeq]. |
| Disorder | MIM: 601704 |
| mRNA | NM_002416, 4505186 |
| Protein | NP_002407, 4505187 |
| Product | C-X-C motif chemokine 9 precursor |
| RefSeq Status | REVIEWED |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04062 | Chemokine signaling pathway |
WikiPathways
| WP75 | Toll-like receptor signaling pathway |
| WP619 | Type II interferon signaling (IFNG) |
Pathway Interaction Database
| cxcr3pathway | CXCR3-mediated signaling events |
| il23pathway | IL23-mediated signaling events |
Reactome
| REACT_21340 | GPCR ligand binding |
| REACT_14819 | Peptide ligand-binding receptors |
| REACT_14828 | Class A/1 (Rhodopsin-like receptors) |
| REACT_19184 | GPCR downstream signaling |
| REACT_19231 | G alpha (i) signalling events |
| REACT_15344 | Chemokine receptors bind chemokines |
| REACT_14797 | Signaling by GPCR |
| Homo sapiens (human) | CXCL9 | NP_002407.1 |
| Pan troglodytes (chimpanzee) | CXCL9 | XP_526582.1 |
| Bos taurus (cattle) | CXCL9 | XP_001789938.1 |
| Mus musculus (house mouse) | Cxcl9 | NP_032625.2 |
| Rattus norvegicus (Norway rat) | Cxcl9 | NP_663705.1 |
| ID | Name | Evidence |
| GO:0006935 | chemotaxis | TAS |
| GO:0006952 | defense response | TAS |
| GO:0006954 | inflammatory response | IEA |
| GO:0006955 | immune response | IEA |
| GO:0006968 | cellular defense response | TAS |
| GO:0007165 | signal transduction | TAS |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | TAS |
| GO:0007267 | cell-cell signaling | TAS |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | EXP |
| GO:0005576 | extracellular region | TAS |
| GO:0005615 | extracellular space | IEA |
| GO:0009897 | external side of plasma membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0005125 | cytokine activity | TAS |
| GO:0008009 | chemokine activity | IEA |
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