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NR3C2 nuclear receptor subfamily 3, group C, member 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000901 Homo sapiens nuclear receptor subfamily 3, group C, member 2 (NR3C2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001166104 Homo sapiens nuclear receptor subfamily 3, group C, member 2 (NR3C2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol NR3C2
Entrez Gene ID 4306
Full Name nuclear receptor subfamily 3, group C, member 2
Synonyms FLJ41052, MCR, MGC133092, MLR, MR, NR3C2VIT
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

MIM: 600983

Pseudohypoaldosteronism type I, autosomal dominant, 177735 (3);

mRNA Protein Product Sequence Price Select
NM_000901, 260656018 NP_000892, 158508572 mineralocorticoid receptor isoform 1 ORF Sequence $750.00
NM_001166104, 260656019 NP_001159576, 260656020 mineralocorticoid receptor isoform 2 ORF Sequence $750.00
hsa04960Aldosterone-regulated sodium reabsorption
WP554ACE Inhibitor Pathway
REACT_15525Nuclear Receptor transcription pathway
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
Homo sapiens (human)NR3C2NP_000892.2
Pan troglodytes (chimpanzee)NR3C2XP_001150516.1
Macaca mulatta (Rhesus monkey)NR3C2XP_001099855.2
Canis lupus familiaris (dog)NR3C2XP_003639585.1
Bos taurus (cattle)NR3C2NP_001178278.1
Mus musculus (house mouse)Nr3c2NP_001077375.1
Rattus norvegicus (Norway rat)Nr3c2NP_037263.1
Gallus gallus (chicken)NR3C2NP_001152817.1
Danio rerio (zebrafish)nr3c2NP_001093873.1
Danio rerio (zebrafish)LOC100534796XP_003197725.1
GeneCards NR3C2
PDB 3VHV, 1Y9R, 2AB2, 1YA3, 3VHU, 2AAX, 2A3I, 2OAX, 2AA5, 2AA2, 2AA7, 2ABI, 2AA6
UniProt P08235, B0ZBF6
MIM 600983
Ensembl ENSG00000151623
HGNC 7979
HPRD 02991

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
mineralocorticoid receptor
mineralocorticoid receptor
aldosterone receptor
mineralocorticoid receptor 1
mineralocorticoid receptor delta


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