LHX8 LIM homeobox 8 [Homo sapiens (human)]
| Gene Symbol | LHX8 |
| Entrez Gene ID | 431707 |
| Full Name | LIM homeobox 8 |
| Synonyms | Lhx7 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p31.1 |
| Summary | Members of the LIM homeobox gene family, such as LHX8, encode transcription regulators that share common structural features. They all contain 2 tandemly repeated cysteine-rich double-zinc finger motifs, called LIM domains, in addition to a homeodomain. The homeodomain is a DNA-binding domain, and the LIM domains are essential for regulating the activity of these molecules by interacting with other proteins. Members of the LIM homeobox gene family are required for the patterning or the specification and differentiation of different cell types during embryonic development (Zhao et al., 1999 [PubMed 10611327]).[supplied by OMIM]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 604425 |
| mRNA | NM_001001933, 50083286 |
| Protein | NP_001001933, 50083287 |
| Product | LIM/homeobox protein Lhx8 |
| RefSeq Status | VALIDATED |
| Homo sapiens (human) | LHX8 | NP_001001933.1 |
| Pan troglodytes (chimpanzee) | LHX8 | XP_524738.2 |
| Canis lupus familiaris (dog) | LHX8 | XP_547330.2 |
| Bos taurus (cattle) | LHX8 | XP_589896.4 |
| Mus musculus (house mouse) | Lhx8 | NP_034843.2 |
| Rattus norvegicus (Norway rat) | Lhx8 | NP_001012219.1 |
| Gallus gallus (chicken) | LHX8 | NP_001035556.1 |
| Danio rerio (zebrafish) | lhx8a | NP_001003980.1 |
| Drosophila melanogaster (fruit fly) | Awh | NP_728906.1 |
| ID | Name | Evidence |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0007611 | learning or memory | IEA |
| GO:0008585 | female gonad development | IEA |
| GO:0021884 | forebrain neuron development | IEA |
| GO:0042475 | odontogenesis of dentine-containing tooth | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
Function
| ID | Name | Evidence |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | IEA |
| GO:0008270 | zinc ion binding | IEA |
| GO:0043565 | sequence-specific DNA binding | IEA |
| GO:0046872 | metal ion binding | IEA |
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