Sequence in raw or FASTA format:
MMP10 matrix metallopeptidase 10 (stromelysin 2) [Homo sapiens (human)]
| Gene Symbol | MMP10 |
| Entrez Gene ID | 4319 |
| Full Name | matrix metallopeptidase 10 (stromelysin 2) |
| Synonyms | SL-2, STMY2 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
11 11q22.3 |
| Summary | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]. |
| Disorder | MIM: 185260 |
| mRNA | NM_002425, 296080749 |
| Protein | NP_002416, 4505205 |
| Product | stromelysin-2 preproprotein |
| RefSeq Status | REVIEWED |
| WP129 | Matrix Metalloproteinases |
| Homo sapiens (human) | MMP10 | NP_002416.1 |
| Pan troglodytes (chimpanzee) | MMP10 | XP_001153881.1 |
| Mus musculus (house mouse) | Mmp10 | NP_062344.1 |
| Rattus norvegicus (Norway rat) | Mmp10 | NP_598198.1 |
| Danio rerio (zebrafish) | mmp30 | NP_001035381.1 |
| ID | Name | Evidence |
| GO:0006508 | proteolysis | IEA |
| GO:0008152 | metabolic process | IEA |
| GO:0030574 | collagen catabolic process | IEA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0005578 | proteinaceous extracellular matrix | IEA |
| GO:0005615 | extracellular space | TAS |
Function
| ID | Name | Evidence |
| GO:0004222 | metalloendopeptidase activity | IEA |
| GO:0005509 | calcium ion binding | IEA |
| GO:0008233 | peptidase activity | IEA |
| GO:0008270 | zinc ion binding | IEA |
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