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MPL myeloproliferative leukemia virus oncogene [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_005373 Homo sapiens myeloproliferative leukemia virus oncogene (MPL), mRNA. ORF Sequence $553.32
Peptide Services
Antibody Services
Protein Services


Gene Symbol MPL
Entrez Gene ID 4352
Full Name myeloproliferative leukemia virus oncogene
Synonyms C-MPL, CD110, MPLV, TPOR
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p34

Summary In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].
Disorder

MIM: 159530

Thrombocytopenia, congenital amegakaryocytic, 604498 (3);

mRNA Protein Product Sequence Price Select
NM_005373, 172072641 NP_005364, 4885491 thrombopoietin receptor precursor Full Length $1275.75
ORF Sequence $553.32
KEGG
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Reactome
REACT_278Platelet Aggregation (Plug Formation)
REACT_604Hemostasis
REACT_798Platelet activation, signaling and aggregation
Homo sapiens (human)MPLNP_005364.1
Macaca mulatta (Rhesus monkey)MPLXP_002801551.1
Bos taurus (cattle)MPLNP_001179592.1
Mus musculus (house mouse)MplNP_001116421.1
Rattus norvegicus (Norway rat)MplXP_345573.4
Gallus gallus (chicken)MPLNP_001001782.1
Danio rerio (zebrafish)mplNP_001003858.1
GeneCards MPL
UniProt P40238
MIM 159530
Ensembl ENSG00000117400
HGNC 7217
HPRD 01161

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
thrombopoietin receptor
Names
thrombopoietin receptor
TPO-R
proto-oncogene c-Mpl
myeloproliferative leukemia protein

Interactant

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