MPL myeloproliferative leukemia virus oncogene [Homo sapiens (human)]
| Gene Symbol | MPL |
| Entrez Gene ID | 4352 |
| Full Name | myeloproliferative leukemia virus oncogene |
| Synonyms | C-MPL, CD110, MPLV, TPOR |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p34 |
| Summary | In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq]. |
| Disorder | MIM: 159530 Thrombocytopenia, congenital amegakaryocytic, 604498 (3); |
| mRNA | NM_005373, 172072641 |
| Protein | NP_005364, 4885491 |
| Product | thrombopoietin receptor precursor |
| RefSeq Status | REVIEWED |
| hsa04630 | Jak-STAT signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
Reactome
| REACT_604 | Hemostasis |
| REACT_622 | Platelet activation triggers |
| REACT_798 | Platelet Activation |
| REACT_20 | Formation of Platelet plug |
| Homo sapiens (human) | MPL | NP_005364.1 |
| Pan troglodytes (chimpanzee) | MPL | XP_001173359.1 |
| Bos taurus (cattle) | MPL | XP_606917.3 |
| Mus musculus (house mouse) | Mpl | NP_034953.1 |
| Rattus norvegicus (Norway rat) | Mpl | XP_345573.3 |
| Gallus gallus (chicken) | MPL | NP_001001782.1 |
| Danio rerio (zebrafish) | mpll | NP_001003858.1 |
| ID | Name | Evidence |
| GO:0007166 | cell surface receptor linked signaling pathway | TAS |
| GO:0007596 | blood coagulation | TAS |
| GO:0008283 | cell proliferation | TAS |
| GO:0030168 | platelet activation | TAS |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | IDA |
| GO:0005887 | integral to plasma membrane | TAS |
Function
| ID | Name | Evidence |
| GO:0004888 | transmembrane receptor activity | TAS |
| GO:0004896 | cytokine receptor activity | IEA |
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