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MPL MPL proto-oncogene, thrombopoietin receptor [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28553 NM_005373 Homo sapiens MPL proto-oncogene, thrombopoietin receptor (MPL), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu28553C NM_005373 Homo sapiens MPL proto-oncogene, thrombopoietin receptor (MPL), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol MPL
Entrez Gene ID 4352
Full Name MPL proto-oncogene, thrombopoietin receptor
Synonyms C-MPL, CD110, MPLV, THCYT2, TPOR
General protein information
Preferred Names
thrombopoietin receptor
Names
thrombopoietin receptor
TPO-R
proto-oncogene c-Mpl
myeloproliferative leukemia protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p34

Summary In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].
Disorder

MIM: 159530

Thrombocytopenia, congenital amegakaryocytic, 604498 (3);

mRNA Protein Product Sequence Price Select
NM_005373, 172072641 NP_005364, 4885491 thrombopoietin receptor precursor ORF Sequence $490.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_278Platelet Aggregation (Plug Formation)
Homo sapiens (human)MPLNP_005364.1
Macaca mulatta (Rhesus monkey)MPLXP_002801551.1
Bos taurus (cattle)MPLNP_001179592.1
Mus musculus (house mouse)MplNP_001116421.1
Rattus norvegicus (Norway rat)MplXP_345573.5
Gallus gallus (chicken)MPLNP_001001782.1
Danio rerio (zebrafish)mplNP_001003858.1
Process
IDNameEvidence
GO:0007166cell surface receptor signaling pathwayTAS
GO:0007596blood coagulationTAS
GO:0008283cell proliferationTAS
GO:0019221cytokine-mediated signaling pathwayIEA
GO:0030168platelet activationTAS
GO:0032642regulation of chemokine productionIEA
GO:0048872homeostasis of number of cellsIEA
Component
IDNameEvidence
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
Function
IDNameEvidence
GO:0004888transmembrane signaling receptor activityTAS
GO:0004896cytokine receptor activityIEA
GeneCards MPL
UniProt P40238
Vega OTTHUMG00000007429
MIM 159530
Ensembl ENSG00000117400
HGNC 7217
HPRD 01161

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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