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MPL MPL proto-oncogene, thrombopoietin receptor [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005373 Homo sapiens MPL proto-oncogene, thrombopoietin receptor (MPL), mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15

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Gene Symbol MPL
Entrez Gene ID 4352
Full Name MPL proto-oncogene, thrombopoietin receptor
Synonyms C-MPL, CD110, MPLV, THCYT2, TPOR
General protein information
Preferred Names
thrombopoietin receptor
thrombopoietin receptor
proto-oncogene c-Mpl
myeloproliferative leukemia protein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].

MIM: 159530

Thrombocytopenia, congenital amegakaryocytic, 604498 (3);

mRNA Protein Product Sequence Price Select
NM_005373, 172072641 NP_005364, 4885491 thrombopoietin receptor precursor ORF Sequence $490.00
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
Homo sapiens (human)MPLNP_005364.1
Macaca mulatta (Rhesus monkey)MPLXP_002801551.1
Bos taurus (cattle)MPLNP_001179592.1
Mus musculus (house mouse)MplNP_001116421.1
Rattus norvegicus (Norway rat)MplXP_345573.5
Gallus gallus (chicken)MPLNP_001001782.1
Danio rerio (zebrafish)mplNP_001003858.1
GO:0007166cell surface receptor signaling pathwayTAS
GO:0007596blood coagulationTAS
GO:0008283cell proliferationTAS
GO:0019221cytokine-mediated signaling pathwayIEA
GO:0030168platelet activationTAS
GO:0032642regulation of chemokine productionIEA
GO:0048872homeostasis of number of cellsIEA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0004888transmembrane signaling receptor activityTAS
GO:0004896cytokine receptor activityIEA
GeneCards MPL
UniProt P40238
Vega OTTHUMG00000007429
MIM 159530
Ensembl ENSG00000117400
HGNC 7217
HPRD 01161

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the MPL gene?

The MPL gene provides instructions for making the thrombopoietin receptor protein, which promotes the growth and division (proliferation) of cells. This receptor is especially important for the proliferation of certain blood cells called megakaryocytes, which produce platelets, the cells involved in blood clotting. Research suggests that the thrombopoietin receptor may also play a role in the maintenance of hematopoietic stem cells, which are stem cells located within the bone marrow that have the potential to develop into red blood cells, white blood cells, and platelets.

The thrombopoietin receptor is turned on (activated) when a protein called thrombopoietin attaches (binds) to it. The activated thrombopoietin receptor stimulates a signaling pathway called the JAK/STAT pathway, which transmits chemical signals from outside the cell to the cell's nucleus and is important for controlling the production of blood cells.


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