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MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001244937 Homo sapiens macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (MST1R), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_002447 Homo sapiens macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (MST1R), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $1198.00 $1149.00 16
XM_005265170 PREDICTED: Homo sapiens macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (MST1R), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol MST1R
Entrez Gene ID 4486
Full Name macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms CD136, CDw136, PTK8, RON
General protein information
Preferred Names
macrophage-stimulating protein receptor
macrophage-stimulating protein receptor
MSP receptor
RON variant 21
RON variant E2E3
MST1R variant RON30
MST1R variant RON62
soluble RON variant 1
soluble RON variant 2
soluble RON variant 3
soluble RON variant 4
c-met-related tyrosine kinase
PTK8 protein tyrosine kinase 8
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011].

MIM: 600168

mRNA Protein Product Sequence Price Select
NM_001244937, 349732250 NP_001231866, 349732251 macrophage-stimulating protein receptor isoform 2 precursor ORF Sequence $1500.00
NM_002447, 153946392 NP_002438, 153946393 macrophage-stimulating protein receptor isoform 1 preproprotein ORF Sequence $999.00
XM_005265170, 578806144 XP_005265227, 578806145 macrophage-stimulating protein receptor isoform X1 ORF Sequence $1500.00
WP244Alpha6-Beta4 Integrin Signaling Pathway
Pathway Interaction Database
amb2_neutrophils_pathwayamb2 Integrin signaling
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
Homo sapiens (human)MST1RNP_002438.2
Pan troglodytes (chimpanzee)MST1RXP_001166551.1
Macaca mulatta (Rhesus monkey)MST1RXP_001105208.2
Canis lupus familiaris (dog)MST1RXP_533823.2
Bos taurus (cattle)MST1RXP_002697081.1
Mus musculus (house mouse)Mst1rNP_033100.2
Rattus norvegicus (Norway rat)Mst1rNP_001100325.2
Gallus gallus (chicken)MST1RNP_001026634.1
Danio rerio (zebrafish)mst1raXP_005166175.1
Danio rerio (zebrafish)mst1rbXP_002663858.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100496572XP_002935671.1
GO:0006928cellular component movementTAS
GO:0006952defense responseTAS
GO:0007165signal transductionTAS
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA
GO:0007275multicellular organismal developmentIEA
GO:0007338single fertilizationTAS
GO:0008284positive regulation of cell proliferationTAS
GO:0009615response to virusIDA
GO:0018108peptidyl-tyrosine phosphorylationIEA
GO:0038145macrophage colony-stimulating factor signaling pathwayTAS
GO:0043406positive regulation of MAP kinase activityIDA
GO:0045087innate immune responseIEA
GO:0051897positive regulation of protein kinase B signalingIDA
GO:0001725stress fiberIEA
GO:0005887integral component of plasma membraneTAS
GO:0005011macrophage colony-stimulating factor receptor activityTAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0019899enzyme bindingIPI
GeneCards MST1R
UniProt B4E058, Q04912
Vega OTTHUMG00000156709
MIM 600168
Ensembl ENSG00000164078
HGNC 7381
HPRD 02545

GeneRIFs: Gene References Into Functions What's a GeneRIF?


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