• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


MSX2 msh homeobox 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002449 Homo sapiens msh homeobox 2 (MSX2), mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 TBD
XM_006714868 PREDICTED: Homo sapiens msh homeobox 2 (MSX2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol MSX2
Entrez Gene ID 4488
Full Name msh homeobox 2
Synonyms CRS2, FPP, HOX8, MSH, PFM, PFM1
General protein information
Preferred Names
homeobox protein MSX-2
homeobox protein MSX-2
msh homeo box 2
homeobox protein Hox-8
msh homeobox homolog 2
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008].

MIM: 123101

Craniosynostosis, type 2, 604757 (3); Parietal foramina 1, 168500

mRNA Protein Product Sequence Price Select
NM_002449, 84452153 NP_002440, 27886557 homeobox protein MSX-2 ORF Sequence $199.00
XM_006714868, 578811121 XP_006714931, 578811122 homeobox protein MSX-2 isoform X1 ORF Sequence $300.00
hsa05166HTLV-I infection
WP2064Neural Crest Differentiation
Homo sapiens (human)MSX2NP_002440.2
Pan troglodytes (chimpanzee)MSX2NP_001129097.2
Macaca mulatta (Rhesus monkey)MSX2XP_001082405.1
Canis lupus familiaris (dog)MSX2NP_001003098.1
Bos taurus (cattle)MSX2NP_001073082.1
Mus musculus (house mouse)Msx2NP_038629.2
Rattus norvegicus (Norway rat)Msx2NP_037114.2
Gallus gallus (chicken)MSX2NP_989890.1
Danio rerio (zebrafish)msxdNP_571351.2
Xenopus (Silurana) tropicalis (western clawed frog)msx2XP_002936749.1
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0001649osteoblast differentiationISS
GO:0002063chondrocyte developmentIEA
GO:0002076osteoblast developmentIEA
GO:0003148outflow tract septum morphogenesisIEA
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formationIEA
GO:0003416endochondral bone growthIEA
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0008285negative regulation of cell proliferationIEA
GO:0009952anterior/posterior pattern specificationIEA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0030513positive regulation of BMP signaling pathwayIEA
GO:0032792negative regulation of CREB transcription factor activityIEA
GO:0035115embryonic forelimb morphogenesisIEA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035313wound healing, spreading of epidermal cellsIEA
GO:0035880embryonic nail plate morphogenesisIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0045599negative regulation of fat cell differentiationIEA
GO:0045617negative regulation of keratinocyte differentiationIEA
GO:0045669positive regulation of osteoblast differentiationIEA
GO:0045892negative regulation of transcription, DNA-templatedISS
GO:0051795positive regulation of catagenIEA
GO:0060346bone trabecula formationIEA
GO:0060363cranial suture morphogenesisTAS
GO:0060364frontal suture morphogenesisIEA
GO:0060444branching involved in mammary gland duct morphogenesisIEA
GO:0061312BMP signaling pathway involved in heart developmentIEA
GO:0070166enamel mineralizationIEA
GO:0071363cellular response to growth factor stimulusIEA
GO:0071392cellular response to estradiol stimulusIEA
GO:0090427activation of meiosisIEA
GO:2000678negative regulation of transcription regulatory region DNA bindingISS
GO:2001055positive regulation of mesenchymal cell apoptotic processIEA
GO:0005667transcription factor complexIEA
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEA
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIEA
GO:0003712transcription cofactor activityISS
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIEA
GO:0043565sequence-specific DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingISS
GeneCards MSX2
UniProt P35548
Vega OTTHUMG00000130556
MIM 123101
Ensembl ENSG00000120149
HGNC 7392
HPRD 00421

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the MSX2 gene?

The MSX2 gene provides instructions for producing a protein that is necessary for proper development throughout the body. The MSX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. The presence of the MSX2 protein seems to be particularly critical for the complete development of the skull.


Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.