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MSX2 msh homeobox 2 [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu21502D NM_002449 Homo sapiens msh homeobox 2 (MSX2), mRNA. pcDNA3.1-C-(k)DYK In-stock TBD Starting from $99
OHu21502D XM_006714868 PREDICTED: Homo sapiens msh homeobox 2 (MSX2), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK In-stock TBD Starting from $99
OHu21502C NM_002449 Homo sapiens msh homeobox 2 (MSX2), mRNA. Customized vector In-stock TBD Starting from $99
OHu21502C XM_006714868 PREDICTED: Homo sapiens msh homeobox 2 (MSX2), transcript variant X1, mRNA. Customized vector In-stock TBD Starting from $99

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Gene Symbol MSX2
Entrez Gene ID 4488
Full Name msh homeobox 2
Synonyms CRS2, FPP, HOX8, MSH, PFM, PFM1
General protein information
Preferred Names
homeobox protein MSX-2
homeobox protein MSX-2
msh homeo box 2
homeobox protein Hox-8
msh homeobox homolog 2
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008].

MIM: 123101

Craniosynostosis, type 2, 604757 (3); Parietal foramina 1, 168500

mRNA Protein Product Sequence Price Select
NM_002449, 84452153 NP_002440, 27886557 homeobox protein MSX-2 ORF Sequence $199.00
XM_006714868, 578811121 XP_006714931, 578811122 homeobox protein MSX-2 isoform X1 ORF Sequence $300.00
hsa05166HTLV-I infection
WP2064Neural Crest Differentiation
Homo sapiens (human)MSX2NP_002440.2
Pan troglodytes (chimpanzee)MSX2NP_001129097.2
Macaca mulatta (Rhesus monkey)MSX2XP_001082405.1
Canis lupus familiaris (dog)MSX2NP_001003098.1
Bos taurus (cattle)MSX2NP_001073082.1
Mus musculus (house mouse)Msx2NP_038629.2
Rattus norvegicus (Norway rat)Msx2NP_037114.2
Gallus gallus (chicken)MSX2NP_989890.1
Danio rerio (zebrafish)msxdNP_571351.2
Xenopus (Silurana) tropicalis (western clawed frog)msx2XP_002936749.1
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0001649osteoblast differentiationISS
GO:0002063chondrocyte developmentIEA
GO:0002076osteoblast developmentIEA
GO:0003148outflow tract septum morphogenesisIEA
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formationIEA
GO:0003416endochondral bone growthIEA
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0008285negative regulation of cell proliferationIEA
GO:0009952anterior/posterior pattern specificationIEA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0030513positive regulation of BMP signaling pathwayIEA
GO:0032792negative regulation of CREB transcription factor activityIEA
GO:0035115embryonic forelimb morphogenesisIEA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035313wound healing, spreading of epidermal cellsIEA
GO:0035880embryonic nail plate morphogenesisIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0045599negative regulation of fat cell differentiationIEA
GO:0045617negative regulation of keratinocyte differentiationIEA
GO:0045669positive regulation of osteoblast differentiationIEA
GO:0045892negative regulation of transcription, DNA-templatedISS
GO:0051795positive regulation of catagenIEA
GO:0060346bone trabecula formationIEA
GO:0060363cranial suture morphogenesisTAS
GO:0060364frontal suture morphogenesisIEA
GO:0060444branching involved in mammary gland duct morphogenesisIEA
GO:0061312BMP signaling pathway involved in heart developmentIEA
GO:0070166enamel mineralizationIEA
GO:0071363cellular response to growth factor stimulusIEA
GO:0071392cellular response to estradiol stimulusIEA
GO:0090427activation of meiosisIEA
GO:2000678negative regulation of transcription regulatory region DNA bindingISS
GO:2001055positive regulation of mesenchymal cell apoptotic processIEA
GO:0005667transcription factor complexIEA
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEA
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIEA
GO:0003712transcription cofactor activityISS
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIEA
GO:0043565sequence-specific DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingISS
GeneCards MSX2
UniProt P35548
Vega OTTHUMG00000130556
MIM 123101
Ensembl ENSG00000120149
HGNC 7392
HPRD 00421

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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