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MTR 5-methyltetrahydrofolate-homocysteine methyltransferase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000254 Homo sapiens 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol MTR
Entrez Gene ID 4548
Full Name 5-methyltetrahydrofolate-homocysteine methyltransferase
Synonyms FLJ33168, FLJ43216, FLJ45386, MS, cblG
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q43

Summary MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. [provided by RefSeq, Jul 2008].
Disorder

MIM: 156570

Methylcobalamin deficiency, cblG type, 250940 (3); {Neural tube

mRNA Protein Product Sequence Price Select
NM_000254, 169790922 NP_000245, 169790923 methionine synthase ORF Sequence $1500.00
KEGG
hsa00450Selenocompound metabolism
hsa00270Cysteine and methionine metabolism
hsa00670One carbon pool by folate
WikiPathways
WP15Selenium Pathway
WP241One Carbon Metabolism
BIOCYC
HUMAN_PWY-5328superpathway of methionine degradation
HUMAN_PWY-2201folate transformations I
HUMAN_ADENOSYLHOMOCYSCAT-PWYmethionine salvage II (mammalia)
Reactome
REACT_6959Phase II conjugation
REACT_13433Biological oxidations
REACT_115639Sulfur amino acid metabolism
REACT_6946Methylation
REACT_111217Metabolism
REACT_13Metabolism of amino acids and derivatives
Homo sapiens (human)MTRNP_000245.2
Pan troglodytes (chimpanzee)MTRXP_514294.2
Macaca mulatta (Rhesus monkey)MTRXP_001109238.1
Canis lupus familiaris (dog)MTRXP_536332.3
Bos taurus (cattle)MTRNP_001025469.1
Mus musculus (house mouse)MtrNP_001074597.1
Rattus norvegicus (Norway rat)MtrNP_110491.1
Gallus gallus (chicken)MTRNP_001026275.1
Danio rerio (zebrafish)mtrNP_932338.1
Caenorhabditis elegansmetr-1NP_496353.1
GeneCards MTR
PDB 2O2K
UniProt Q99707
MIM 156570
Ensembl ENSG00000116984
HGNC 7468
HPRD 01136

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
methionine synthase
Names
methionine synthase
cobalamin-dependent methionine synthase
vitamin-B12 dependent methionine synthase
5-methyltetrahydrofolate-homocysteine methyltransferase 1
NP_000245.2

Interactant



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