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SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000488 Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
XM_005245198 PREDICTED: Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol SERPINC1
Entrez Gene ID 462
Full Name serpin peptidase inhibitor, clade C (antithrombin), member 1
Synonyms AT3, AT3D, ATIII, THPH7
General protein information
Preferred Names
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009].

MIM: 107300

Antithrombin III deficiency, 613118 (3)

mRNA Protein Product Sequence Price Select
NM_000488, 254588059 NP_000479, 4502261 antithrombin-III precursor ORF Sequence $360.00
XM_005245198, 578800975 XP_005245255, 530364787 antithrombin-III isoform X1 ORF Sequence $550.00
hsa04610Complement and coagulation cascades
Pathway Interaction Database
glypican_1pathwayGlypican 1 network
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1439Common Pathway
Homo sapiens (human)SERPINC1NP_000479.1
Pan troglodytes (chimpanzee)SERPINC1XP_001151521.1
Macaca mulatta (Rhesus monkey)SERPINC1NP_001098053.1
Canis lupus familiaris (dog)SERPINC1XP_537187.4
Bos taurus (cattle)SERPINC1NP_001029870.1
Mus musculus (house mouse)Serpinc1NP_543120.1
Rattus norvegicus (Norway rat)Serpinc1NP_001012027.1
Gallus gallus (chicken)SERPINC1XP_422282.3
Danio rerio (zebrafish)serpinc1NP_878283.1
Xenopus (Silurana) tropicalis (western clawed frog)serpinc1NP_001008153.1
GO:0007584response to nutrientIEA
GO:0007596blood coagulationTAS
GO:0010951negative regulation of endopeptidase activityIBA
GO:0030162regulation of proteolysisIBA
GO:0050728negative regulation of inflammatory responseIEA
GO:2000266regulation of blood coagulation, intrinsic pathwayIEA
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
GO:0002020protease bindingIPI
GO:0004867serine-type endopeptidase inhibitor activityIBA
GO:0004867serine-type endopeptidase inhibitor activityNAS
GO:0005515protein bindingIPI
GO:0008201heparin bindingIEA
GeneCards SERPINC1
PDB 1SR5, 2HIJ, 1AZX, 1BR8, 2GD4, 2BEH, 3EVJ, 1JVQ, 2B5T, 1ANT, 1E04, 1ATH, 1DZH, 2ZNH, 1TB6, 1E03, 2ANT, 1OYH, 1R1L, 4EB1, 3KCG, 2B4X, 1E05, 1T1F, 1LK6, 1DZG, 1NQ9
UniProt P01008
Vega OTTHUMG00000037276
MIM 107300
Ensembl ENSG00000117601
HGNC 775
HPRD 00122

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SERPINC1 gene?

The SERPINC1 gene provides instructions for making a protein called antithrombin (previously known as antithrombin III), which is a type of serine protease inhibitor (serpin). Serpins help control several types of chemical reactions by blocking the activity of certain proteins. Antithrombin is found in the bloodstream and is important for controlling blood clotting.

Antithrombin blocks the activity of proteins that promote blood clotting, especially a protein called thrombin. Antithrombin attaches (binds) to thrombin and certain other clotting proteins, which are then cleared from the bloodstream by the liver.

While one part of antithrombin binds to thrombin and other clotting proteins, another part of the protein binds to a substance called heparin. Antithrombin changes its shape when it binds to heparin. This change in shape allows antithrombin to inactivate clotting proteins at a much faster rate.


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