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SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000488 Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol SERPINC1
Entrez Gene ID 462
Full Name serpin peptidase inhibitor, clade C (antithrombin), member 1
Synonyms AT3, ATIII, MGC22579
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009].

MIM: 107300

Antithrombin III deficiency, 613118 (3)

mRNA Protein Product Sequence Price Select
NM_000488, 254588059 NP_000479, 4502261 antithrombin-III precursor ORF Sequence $360.00
hsa04610Complement and coagulation cascades
Pathway Interaction Database
glypican_1pathwayGlypican 1 network
WP558Complement and Coagulation Cascades
REACT_1439Common Pathway
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
Homo sapiens (human)SERPINC1NP_000479.1
Pan troglodytes (chimpanzee)SERPINC1XP_001151521.1
Macaca mulatta (Rhesus monkey)SERPINC1NP_001098053.1
Canis lupus familiaris (dog)SERPINC1XP_537187.4
Bos taurus (cattle)SERPINC1NP_001029870.1
Mus musculus (house mouse)Serpinc1NP_543120.1
Rattus norvegicus (Norway rat)Serpinc1NP_001012027.1
Gallus gallus (chicken)SERPINC1XP_422282.3
Danio rerio (zebrafish)serpinc1NP_878283.1
Arabidopsis thaliana (thale cress)SRP3NP_176586.1
Arabidopsis thaliana (thale cress)AT1G62160NP_176407.2
Arabidopsis thaliana (thale cress)AT1G62170NP_176408.1
Arabidopsis thaliana (thale cress)SRP2NP_179060.1
Arabidopsis thaliana (thale cress)AT2G35580NP_181101.1
Arabidopsis thaliana (thale cress)AT1G64010NP_176584.1
GeneCards SERPINC1
PDB 1SR5, 2HIJ, 1AZX, 1BR8, 2GD4, 2BEH, 3EVJ, 1JVQ, 2B5T, 1ANT, 1E04, 1ATH, 1DZH, 2ZNH, 1TB6, 1E03, 2ANT, 1OYH, 1R1L, 4EB1, 3KCG, 2B4X, 1E05, 1T1F, 1LK6, 1DZG, 1NQ9
UniProt P01008
MIM 107300
Ensembl ENSG00000117601
HGNC 775
HPRD 00122

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1


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