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MYH6 myosin, heavy chain 6, cardiac muscle, alpha [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002471 Homo sapiens myosin, heavy chain 6, cardiac muscle, alpha (MYH6), mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005267694 PREDICTED: Homo sapiens myosin, heavy chain 6, cardiac muscle, alpha (MYH6), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005267695 PREDICTED: Homo sapiens myosin, heavy chain 6, cardiac muscle, alpha (MYH6), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006720151 PREDICTED: Homo sapiens myosin, heavy chain 6, cardiac muscle, alpha (MYH6), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_006720152 PREDICTED: Homo sapiens myosin, heavy chain 6, cardiac muscle, alpha (MYH6), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $2699.00 30

*Business Day

Related Services

Gene Symbol MYH6
Entrez Gene ID 4624
Full Name myosin, heavy chain 6, cardiac muscle, alpha
Synonyms ASD3, CMD1EE, CMH14, MYHC, MYHCA, SSS3, alpha-MHC
General protein information
Preferred Names
myosin heavy chain 6
myosin heavy chain, cardiac muscle alpha isoform
myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Mar 2010].

MIM: 160710

Cardiomyopathy, familial hypertrophic, 14, 613251 (3); Atrial septal

mRNA Protein Product Sequence Price Select
NM_002471, 289803014 NP_002462, 156104908 myosin-6 ORF Sequence $2500.00
XM_005267694, 530403842 XP_005267751, 530403843 myosin-6 isoform X1 ORF Sequence $2500.00
XM_005267695, 578825825 XP_005267752, 530403845 myosin-6 isoform X2 ORF Sequence $750.00
XM_006720151, 578825821 XP_006720214, 578825822 myosin-6 isoform X3 ORF Sequence $2500.00
XM_006720152, 578825823 XP_006720215, 578825824 myosin-6 isoform X4 ORF Sequence $2500.00
hsa04530Tight junction
hsa05416Viral myocarditis
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04261Adrenergic signaling in cardiomyocytes
hsa04919Thyroid hormone signaling pathway
WP383Striated Muscle Contraction
WP2406Cardiac Progenitor Differentiation
REACT_11123Membrane Trafficking
REACT_16969Striated Muscle Contraction
REACT_17044Muscle contraction
REACT_147867Translocation of GLUT4 to the plasma membrane
Homo sapiens (human)MYH6NP_002462.2
Pan troglodytes (chimpanzee)MYH6XP_003952494.1
Macaca mulatta (Rhesus monkey)MYH6XP_001102827.2
Canis lupus familiaris (dog)MYH6XP_003435121.2
Bos taurus (cattle)MYH6XP_002690549.1
Mus musculus (house mouse)Myh6NP_034986.1
Rattus norvegicus (Norway rat)Myh6NP_058935.2
Gallus gallus (chicken)MYH15NP_990097.1
Danio rerio (zebrafish)myh6NP_942118.1
Xenopus (Silurana) tropicalis (western clawed frog)myh6XP_004910815.1
GO:0001701in utero embryonic developmentISS
GO:0002026regulation of the force of heart contractionIDA
GO:0002026regulation of the force of heart contractionISS
GO:0002027regulation of heart rateIDA
GO:0006200ATP catabolic processIDA
GO:0006936muscle contractionIDA
GO:0006941striated muscle contractionIMP
GO:0006941striated muscle contractionISS
GO:0007512adult heart developmentIMP
GO:0007522visceral muscle developmentISS
GO:0008016regulation of heart contractionISS
GO:0008217regulation of blood pressureISS
GO:0030049muscle filament slidingIMP
GO:0030049muscle filament slidingTAS
GO:0030239myofibril assemblyISS
GO:0030509BMP signaling pathwayIEA
GO:0043462regulation of ATPase activityISS
GO:0045214sarcomere organizationISS
GO:0048739cardiac muscle fiber developmentISS
GO:0055009atrial cardiac muscle tissue morphogenesisIMP
GO:0055010ventricular cardiac muscle tissue morphogenesisIMP
GO:0060070canonical Wnt signaling pathwayIEA
GO:0060420regulation of heart growthIEA
GO:0001725stress fiberIEA
GO:0005859muscle myosin complexTAS
GO:0005925focal adhesionIDA
GO:0016459myosin complexTAS
GO:0030018Z discIEA
GO:0032982myosin filamentIEA
GO:0000146microfilament motor activityIDA
GO:0000146microfilament motor activityISS
GO:0003779actin bindingIEA
GO:0005516calmodulin bindingIEA
GO:0005524ATP bindingIEA
GO:0016887ATPase activityIDA
GO:0019901protein kinase bindingIPI
GO:0030898actin-dependent ATPase activityIMP
GeneCards MYH6
UniProt P13533
Vega OTTHUMG00000028753
MIM 160710
Ensembl ENSG00000197616
HGNC 7576
HPRD 01171

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the MYH6 gene?

The MYH6 gene provides instructions for making a protein known as the cardiac alpha (α)-myosin heavy chain. This protein is found in heart (cardiac) muscle cells, where it forms part of a larger protein called type II myosin. Type II myosin helps generate the mechanical force that is needed for cardiac muscle to contract, allowing the heart to pump blood to the rest of the body.

Type II myosin is one of the major components of cell structures called sarcomeres. These structures are the basic units of muscle contraction. Sarcomeres are composed of thick filaments made up of type II myosin and thin filaments made up of another protein called actin. The overlapping thick and thin filaments attach to each other and release, which allows the filaments to move relative to one another so that muscles can contract. Sarcomeres also appear to have an important role in the early development of structures in the heart.


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