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MYH9 myosin, heavy chain 9, non-muscle [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22915 NM_002473 Homo sapiens myosin, heavy chain 9, non-muscle (MYH9), mRNA. pcDNA3.1+-DYK On-demand 30 $2699.00
OHu22915C NM_002473 Homo sapiens myosin, heavy chain 9, non-muscle (MYH9), mRNA. Customized vector On-demand 30 $2699.00

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Gene Symbol MYH9
Entrez Gene ID 4627
Full Name myosin, heavy chain 9, non-muscle
Synonyms BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA
General protein information
Preferred Names
myosin-9
Names
myosin-9
myosin heavy chain 9
non-muscle myosin heavy chain A
non-muscle myosin heavy chain IIa
nonmuscle myosin heavy chain II-A
myosin heavy chain, non-muscle IIa
cellular myosin heavy chain, type A
non-muscle myosin heavy polypeptide 9
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.1

Summary This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011].
Disorder

MIM: 160775

May-Hegglin anomaly, 155100 (3); Fechtner syndrome, 153640 (3);

mRNA Protein Product Sequence Price Select
NM_002473, 225703132 NP_002464, 12667788 myosin-9 ORF Sequence $2500.00
KEGG
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
hsa05132Salmonella infection
Reactome
REACT_18266Axon guidance
REACT_19259Sema4D in semaphorin signaling
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19271Semaphorin interactions
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_111045Developmental Biology
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160086Regulation of actin dynamics for phagocytic cup formation
Homo sapiens (human)MYH9NP_002464.1
Pan troglodytes (chimpanzee)MYH9XP_003953928.1
Canis lupus familiaris (dog)MYH9NP_001104237.1
Bos taurus (cattle)MYH9NP_001179691.1
Mus musculus (house mouse)Myh9NP_071855.2
Rattus norvegicus (Norway rat)LOC100911597XP_003750426.1
Gallus gallus (chicken)MYH9NP_990808.1
Danio rerio (zebrafish)myh9aNP_001091647.2
Xenopus (Silurana) tropicalis (western clawed frog)myh9XP_002934764.2
Process
IDNameEvidence
GO:0000212meiotic spindle organizationIEA
GO:0000910cytokinesisIMP
GO:0001525angiogenesisIDA
GO:0001701in utero embryonic developmentIEA
GO:0001768establishment of T cell polarityIEA
GO:0006200ATP catabolic processIDA
GO:0006509membrane protein ectodomain proteolysisIDA
GO:0007229integrin-mediated signaling pathwayNAS
GO:0007411axon guidanceTAS
GO:0007520myoblast fusionIEA
GO:0008360regulation of cell shapeIMP
GO:0015031protein transportIMP
GO:0016337single organismal cell-cell adhesionIEA
GO:0030048actin filament-based movementIDA
GO:0030220platelet formationIMP
GO:0030224monocyte differentiationIEP
GO:0031032actomyosin structure organizationIDA
GO:0031532actin cytoskeleton reorganizationIMP
GO:0032796uropod organizationIEA
GO:0038032termination of G-protein coupled receptor signaling pathwayIEA
GO:0043534blood vessel endothelial cell migrationIMP
GO:0050900leukocyte migrationNAS
GO:0051295establishment of meiotic spindle localizationIEA
Component
IDNameEvidence
GO:0001725stress fiberIDA
GO:0001726ruffleIDA
GO:0001772immunological synapseIDA
GO:0001931uropodIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005819spindleIEA
GO:0005826actomyosin contractile ringIDA
GO:0005829cytosolIDA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneIDA
GO:0005913cell-cell adherens junctionIEA
GO:0008180COP9 signalosomeIDA
GO:0008305integrin complexIDA
GO:0015629actin cytoskeletonIDA
GO:0016020membraneIDA
GO:0016460myosin II complexIDA
GO:0030863cortical cytoskeletonIEA
GO:0031252cell leading edgeIDA
GO:0031594neuromuscular junctionIEA
GO:0032154cleavage furrowIDA
GO:0042641actomyosinIDA
GO:0043234protein complexIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0097513myosin II filamentIDA
Function
IDNameEvidence
GO:0000146microfilament motor activityIDA
GO:0003774motor activityNAS
GO:0003779actin bindingIDA
GO:0005515protein bindingIPI
GO:0005516calmodulin bindingIEA
GO:0005524ATP bindingIDA
GO:0016887ATPase activityIDA
GO:0030898actin-dependent ATPase activityIDA
GO:0030898actin-dependent ATPase activityIDA
GO:0042803protein homodimerization activityIDA
GO:0043495protein anchorIMP
GO:0043531ADP bindingIDA
GO:0044822poly(A) RNA bindingIDA
GO:0051015actin filament bindingIDA
GO:0051015actin filament bindingIDA
GO:0051015actin filament bindingNAS
GeneCards MYH9
UniProt P35579
Vega OTTHUMG00000030429
MIM 160775
Ensembl ENSG00000100345
HGNC 7579
HPRD 01177

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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