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MYH9 myosin, heavy chain 9, non-muscle [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002473 Homo sapiens myosin, heavy chain 9, non-muscle (MYH9), mRNA. GenEZ ORF Cloning On-demand $2699.00 30

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Gene Symbol MYH9
Entrez Gene ID 4627
Full Name myosin, heavy chain 9, non-muscle
Synonyms BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA
General protein information
Preferred Names
myosin-9
Names
myosin-9
myosin heavy chain 9
non-muscle myosin heavy chain A
non-muscle myosin heavy chain IIa
nonmuscle myosin heavy chain II-A
myosin heavy chain, non-muscle IIa
cellular myosin heavy chain, type A
non-muscle myosin heavy polypeptide 9
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.1

Summary This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011].
Disorder

MIM: 160775

May-Hegglin anomaly, 155100 (3); Fechtner syndrome, 153640 (3);

mRNA Protein Product Sequence Price Select
NM_002473, 225703132 NP_002464, 12667788 myosin-9 ORF Sequence $2500.00
KEGG
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
hsa05132Salmonella infection
Reactome
REACT_18266Axon guidance
REACT_19259Sema4D in semaphorin signaling
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19271Semaphorin interactions
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_111045Developmental Biology
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160086Regulation of actin dynamics for phagocytic cup formation
Homo sapiens (human)MYH9NP_002464.1
Pan troglodytes (chimpanzee)MYH9XP_003953928.1
Canis lupus familiaris (dog)MYH9NP_001104237.1
Bos taurus (cattle)MYH9NP_001179691.1
Mus musculus (house mouse)Myh9NP_071855.2
Rattus norvegicus (Norway rat)LOC100911597XP_003750426.1
Gallus gallus (chicken)MYH9NP_990808.1
Danio rerio (zebrafish)myh9aNP_001091647.2
Xenopus (Silurana) tropicalis (western clawed frog)myh9XP_002934764.2
Process
IDNameEvidence
GO:0000212meiotic spindle organizationIEA
GO:0000910cytokinesisIMP
GO:0001525angiogenesisIDA
GO:0001701in utero embryonic developmentIEA
GO:0001768establishment of T cell polarityIEA
GO:0006200ATP catabolic processIDA
GO:0006509membrane protein ectodomain proteolysisIDA
GO:0007229integrin-mediated signaling pathwayNAS
GO:0007411axon guidanceTAS
GO:0007520myoblast fusionIEA
GO:0008360regulation of cell shapeIMP
GO:0015031protein transportIMP
GO:0016337single organismal cell-cell adhesionIEA
GO:0030048actin filament-based movementIDA
GO:0030220platelet formationIMP
GO:0030224monocyte differentiationIEP
GO:0031032actomyosin structure organizationIDA
GO:0031532actin cytoskeleton reorganizationIMP
GO:0032796uropod organizationIEA
GO:0038032termination of G-protein coupled receptor signaling pathwayIEA
GO:0043534blood vessel endothelial cell migrationIMP
GO:0050900leukocyte migrationNAS
GO:0051295establishment of meiotic spindle localizationIEA
Component
IDNameEvidence
GO:0001725stress fiberIDA
GO:0001726ruffleIDA
GO:0001772immunological synapseIDA
GO:0001931uropodIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005819spindleIEA
GO:0005826actomyosin contractile ringIDA
GO:0005829cytosolIDA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneIDA
GO:0005913cell-cell adherens junctionIEA
GO:0008180COP9 signalosomeIDA
GO:0008305integrin complexIDA
GO:0015629actin cytoskeletonIDA
GO:0016020membraneIDA
GO:0016460myosin II complexIDA
GO:0030863cortical cytoskeletonIEA
GO:0031252cell leading edgeIDA
GO:0031594neuromuscular junctionIEA
GO:0032154cleavage furrowIDA
GO:0042641actomyosinIDA
GO:0043234protein complexIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0097513myosin II filamentIDA
Function
IDNameEvidence
GO:0000146microfilament motor activityIDA
GO:0003774motor activityNAS
GO:0003779actin bindingIDA
GO:0005515protein bindingIPI
GO:0005516calmodulin bindingIEA
GO:0005524ATP bindingIDA
GO:0016887ATPase activityIDA
GO:0030898actin-dependent ATPase activityIDA
GO:0030898actin-dependent ATPase activityIDA
GO:0042803protein homodimerization activityIDA
GO:0043495protein anchorIMP
GO:0043531ADP bindingIDA
GO:0044822poly(A) RNA bindingIDA
GO:0051015actin filament bindingIDA
GO:0051015actin filament bindingIDA
GO:0051015actin filament bindingNAS
GeneCards MYH9
UniProt P35579
Vega OTTHUMG00000030429
MIM 160775
Ensembl ENSG00000100345
HGNC 7579
HPRD 01177

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the MYH9 gene?

The MYH9 gene provides instructions for making a protein called myosin-9. This protein is one part (subunit) of the myosin IIA protein.

There are three forms of myosin II, called myosin IIA, myosin IIB and myosin IIC. They play roles in cell movement (cell motility); maintenance of cell shape; and cytokinesis, which is the step in cell division when the fluid surrounding the nucleus (the cytoplasm) divides to form two separate cells. While some cells use more than one type of myosin II, certain blood cells such as platelets and white blood cells (leukocytes) use only myosin IIA.

Each type of myosin II protein consists of two heavy chains and four light chains. The heavy chains each have two parts: a head region and a tail region. The head region interacts with actin, a protein that is important for cell movement and shape. The long tail region interacts with other proteins, including the tail regions of other myosin proteins.

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