MYH9 myosin, heavy chain 9, non-muscle [Homo sapiens (human)]

Gene Symbol	MYH9
Entrez Gene ID	4627
Full Name	myosin, heavy chain 9, non-muscle
Synonyms	DFNA17, EPSTS, FTNS, MGC104539, MHA, NMHC-II-A, NMMHCA
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:22 Map Location:22q13.1
Summary	This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq].
Disorder	MIM: 160775 May-Hegglin anomaly, 155100 (3); Fechtner syndrome, 153640 (3);

KEGG

hsa05416	Viral myocarditis
hsa04530	Tight junction
hsa04810	Regulation of actin cytoskeleton

Reactome

REACT_18266	Axon guidance
REACT_19277	Sema4D induced cell migration and growth-cone collapse
REACT_19259	Sema4D in semaphorin signaling
REACT_19271	Semaphorin interactions

Homo sapiens (human)	MYH9	NP_002464.1
Canis lupus familiaris (dog)	MYH9	XP_861941.1
Mus musculus (house mouse)	Myh9	NP_071855.2
Rattus norvegicus (Norway rat)	Myh9	NP_037326.1
Gallus gallus (chicken)	MYH9	NP_990808.1
Danio rerio (zebrafish)	myh9l1	XP_001920098.2

Process

ID	Name	Evidence
GO:0000212	meiotic spindle organization	IEA
GO:0000904	cell morphogenesis involved in differentiation	IEA
GO:0000910	cytokinesis	IMP
GO:0001525	angiogenesis	IDA
GO:0001701	in utero embryonic development	IEA
GO:0001768	establishment of T cell polarity	IEA
GO:0006200	ATP catabolic process	IDA
GO:0006509	membrane protein ectodomain proteolysis	IDA
GO:0006928	cellular component movement	IEA
GO:0007132	meiotic metaphase I	IEA
GO:0007229	integrin-mediated signaling pathway	NAS
GO:0007411	axon guidance	TAS
GO:0007520	myoblast fusion	IEA
GO:0008360	regulation of cell shape	IMP
GO:0015031	protein transport	IMP
GO:0016337	cell-cell adhesion	IEA
GO:0030048	actin filament-based movement	IDA
GO:0030220	platelet formation	IMP
GO:0030224	monocyte differentiation	IEP
GO:0031532	actin cytoskeleton reorganization	IMP
GO:0032796	uropod organization	IEA
GO:0043534	blood vessel endothelial cell migration	IMP
GO:0050900	leukocyte migration	NAS
GO:0051295	establishment of meiotic spindle localization	IEA

Component

ID	Name	Evidence
GO:0001725	stress fiber	IDA
GO:0001726	ruffle	IDA
GO:0001772	immunological synapse	IDA
GO:0001931	uropod	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005819	spindle	IEA
GO:0005826	actomyosin contractile ring	IDA
GO:0005829	cytosol	IDA
GO:0005886	plasma membrane	IDA
GO:0005886	plasma membrane	IDA
GO:0005913	cell-cell adherens junction	IEA
GO:0005938	cell cortex	IEA
GO:0008305	integrin complex	IDA
GO:0015629	actin cytoskeleton	IDA
GO:0016459	myosin complex	IEA
GO:0030863	cortical cytoskeleton	IEA
GO:0031252	cell leading edge	IDA
GO:0031594	neuromuscular junction	IEA
GO:0032154	cleavage furrow	IDA
GO:0043234	protein complex	IDA

Function

ID	Name	Evidence
GO:0000146	microfilament motor activity	IDA
GO:0000166	nucleotide binding	IEA
GO:0003774	motor activity	NAS
GO:0003779	actin binding	IDA
GO:0005515	protein binding	IPI
GO:0005516	calmodulin binding	IEA
GO:0005524	ATP binding	IDA
GO:0016887	ATPase activity	IDA
GO:0030898	actin-dependent ATPase activity	IDA
GO:0042803	protein homodimerization activity	IDA
GO:0043495	protein anchor	IMP
GO:0043531	ADP binding	IDA
GO:0051015	actin filament binding	IDA
GO:0051015	actin filament binding	NAS

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RefSeq Accession	Definition	Sequence	Price	Select
NM_002473	Homo sapiens myosin, heavy chain 9, non-muscle (MYH9), mRNA.	Full Length	$3377.25
NM_002473		ORF Sequence	$2647.35