MYL1 myosin, light chain 1, alkali; skeletal, fast [Homo sapiens (human)]
| Gene Symbol | MYL1 |
| Entrez Gene ID | 4632 |
| Full Name | myosin, light chain 1, alkali; skeletal, fast |
| Synonyms | MLC1F, MLC3F |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
2 2q33-q34 |
| Summary | Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq]. |
| Disorder | MIM: 160780 |
| mRNA | NM_079422, 115527083 |
| Protein | NP_524146, 17986275 |
| Product | myosin light chain 1/3, skeletal muscle isoform isoform 3f |
| RefSeq Status | REVIEWED |
| mRNA | NM_079420, 115527084 |
| Protein | NP_524144, 17986273 |
| Product | myosin light chain 1/3, skeletal muscle isoform isoform 1f |
| RefSeq Status | REVIEWED |
| WP383 | Striated Muscle Contraction |
| WP51 | Regulation of Actin Cytoskeleton |
| WP524 | G13 Signaling Pathway |
Reactome
| REACT_16969 | Striated Muscle Contraction |
| REACT_17044 | Muscle contraction |
| Homo sapiens (human) | MYL1 | NP_524144.1 |
| Pan troglodytes (chimpanzee) | MYL1 | XP_516064.2 |
| Canis lupus familiaris (dog) | MYL1 | XP_536054.2 |
| Bos taurus (cattle) | MYL1 | NP_001073046.1 |
| Mus musculus (house mouse) | Myl1 | NP_067260.1 |
| Rattus norvegicus (Norway rat) | Myl1 | NP_064489.1 |
| Gallus gallus (chicken) | MYL1 | NP_001038097.1 |
| Danio rerio (zebrafish) | zgc:77231 | NP_956294.1 |
| Caenorhabditis elegans | mlc-3 | NP_741145.1 |
| ID | Name | Evidence |
| GO:0006936 | muscle contraction | IDA |
| GO:0007517 | muscle organ development | NAS |
| GO:0030049 | muscle filament sliding | NAS |
| GO:0030049 | muscle filament sliding | TAS |
| GO:0060048 | cardiac muscle contraction | IEA |
Component
| ID | Name | Evidence |
| GO:0005829 | cytosol | TAS |
| GO:0005859 | muscle myosin complex | NAS |
| GO:0016459 | myosin complex | IEA |
| GO:0030016 | myofibril | IDA |
| GO:0030017 | sarcomere | NAS |
Function
| ID | Name | Evidence |
| GO:0005509 | calcium ion binding | IEA |
| GO:0008307 | structural constituent of muscle | NAS |
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