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MYL2 myosin, light chain 2, regulatory, cardiac, slow [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000432 Homo sapiens myosin, light chain 2, regulatory, cardiac, slow (MYL2), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol MYL2
Entrez Gene ID 4633
Full Name myosin, light chain 2, regulatory, cardiac, slow
Synonyms CMH10, MLC2
General protein information
Preferred Names
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Names
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
MLC-2
MLC-2v
RLC of myosin
myosin light chain 2
regulatory light chain of myosin
cardiac ventricular myosin light chain 2
slow cardiac myosin regulatory light chain 2
myosin, light polypeptide 2, regulatory, cardiac, slow
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.11

Summary Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].
Disorder

MIM: 160781

Cardiomyopathy, familial hypertrophic, 10, 608758 (3)

mRNA Protein Product Sequence Price Select
NM_000432, 190358510 NP_000423, 94981553 myosin regulatory light chain 2, ventricular/cardiac muscle isoform ORF Sequence $159.00
KEGG
hsa04510Focal adhesion
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
hsa04670Leukocyte transendothelial migration
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04261Adrenergic signaling in cardiomyocytes
WikiPathways
WP289Myometrial Relaxation and Contraction Pathways
WP383Striated Muscle Contraction
WP2406Cardiac Progenitor Differentiation
Pathway Interaction Database
ecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
cdc42_pathwayCDC42 signaling events
ncadherinpathwayN-cadherin signaling events
rhoa_pathwayRhoA signaling pathway
Reactome
REACT_16969Striated Muscle Contraction
REACT_17044Muscle contraction
Homo sapiens (human)MYL2NP_000423.2
Pan troglodytes (chimpanzee)MYL2XP_001144828.2
Macaca mulatta (Rhesus monkey)MYL2XP_001100796.1
Canis lupus familiaris (dog)MYL2NP_001003069.1
Bos taurus (cattle)MYL2NP_001030197.1
Mus musculus (house mouse)Myl2NP_034991.3
Rattus norvegicus (Norway rat)Myl2NP_001030329.2
Gallus gallus (chicken)MYL2NP_001258858.1
Danio rerio (zebrafish)myl2bNP_001035134.1
Danio rerio (zebrafish)LOC100537244XP_003198611.2
Xenopus (Silurana) tropicalis (western clawed frog)myl2NP_001107717.1
Process
IDNameEvidence
GO:0006942regulation of striated muscle contractionTAS
GO:0009791post-embryonic developmentIEA
GO:0030049muscle filament slidingTAS
GO:0030308negative regulation of cell growthIMP
GO:0042694muscle cell fate specificationIEA
GO:0048747muscle fiber developmentIEA
GO:0055003cardiac myofibril assemblyISS
GO:0055010ventricular cardiac muscle tissue morphogenesisIMP
GO:0060047heart contractionISS
GO:0060048cardiac muscle contractionIEA
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0005856cytoskeletonIDA
GO:0015629actin cytoskeletonIDA
GO:0016459myosin complexTAS
GO:0030016myofibrilNAS
GO:0030017sarcomereTAS
GO:0031672A bandIEA
Function
IDNameEvidence
GO:0003785actin monomer bindingIDA
GO:0005509calcium ion bindingIDA
GO:0005515protein bindingIPI
GO:0008307structural constituent of muscleNAS
GO:0032036myosin heavy chain bindingNAS
GeneCards MYL2
UniProt Q6IB42, P10916
Vega OTTHUMG00000169535
MIM 160781
Ensembl ENSG00000111245
HGNC 7583
HPRD 01181

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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