• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


NCF2 neutrophil cytosolic factor 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000433 Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001127651 Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001190789 Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001190794 Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005245207 PREDICTED: Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol NCF2
Entrez Gene ID 4688
Full Name neutrophil cytosolic factor 2
Synonyms NCF-2, NOXA2, P67-PHOX, P67PHOX
General protein information
Preferred Names
neutrophil cytosol factor 2
Names
neutrophil cytosol factor 2
NADPH oxidase activator 2
67 kDa neutrophil oxidase factor
neutrophil NADPH oxidase factor 2
chronic granulomatous disease, autosomal 2
neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q25

Summary This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010].
Disorder

MIM: 608515

Chronic granulomatous disease due to deficiency of NCF-2, 233710 (3)

mRNA Protein Product Sequence Price Select
NM_000433, 189083740 NP_000424, 67189970 neutrophil cytosol factor 2 isoform 1 ORF Sequence $550.00
NM_001127651, 299829277 NP_001121123, 189083742 neutrophil cytosol factor 2 isoform 1 ORF Sequence $550.00
NM_001190789, 299829278 NP_001177718, 299829279 neutrophil cytosol factor 2 isoform 3 ORF Sequence $550.00
NM_001190794, 299829293 NP_001177723, 299829294 neutrophil cytosol factor 2 isoform 2 ORF Sequence $550.00
XM_005245207, 530364804 XP_005245264, 530364805 neutrophil cytosol factor 2 isoform X1 ORF Sequence $550.00
KEGG
hsa04670Leukocyte transendothelial migration
hsa05140Leishmaniasis
hsa04145Phagosome
hsa04380Osteoclast differentiation
WikiPathways
WP2380BDNF signaling pathway
Pathway Interaction Database
rac1_pathwayRAC1 signaling pathway
Reactome
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_111119Antigen processing-Cross presentation
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_116125Disease
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
Homo sapiens (human)NCF2NP_000424.2
Pan troglodytes (chimpanzee)NCF2XP_001163353.1
Canis lupus familiaris (dog)NCF2NP_001095302.1
Bos taurus (cattle)NCF2NP_776545.1
Mus musculus (house mouse)Ncf2NP_035007.1
Rattus norvegicus (Norway rat)Ncf2NP_001094454.1
Gallus gallus (chicken)NCF2XP_422288.2
Danio rerio (zebrafish)ncf2NP_001103932.1
Xenopus (Silurana) tropicalis (western clawed frog)ncf2NP_001029119.1
Process
IDNameEvidence
GO:0002474antigen processing and presentation of peptide antigen via MHC class ITAS
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTAS
GO:0006801superoxide metabolic processTAS
GO:0006968cellular defense responseTAS
GO:0007568agingIEA
GO:0009749response to glucoseIEA
GO:0014823response to activityIEA
GO:0032496response to lipopolysaccharideIEA
GO:0032570response to progesteroneIEA
GO:0032870cellular response to hormone stimulusIEA
GO:0034616response to laminar fluid shear stressIEA
GO:0042493response to drugIEA
GO:0042554superoxide anion generationTAS
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class ITAS
GO:0043525positive regulation of neuron apoptotic processIEA
GO:0045087innate immune responseTAS
GO:0045730respiratory burstTAS
GO:0045777positive regulation of blood pressureIEA
GO:0051701interaction with hostTAS
GO:0055093response to hyperoxiaIEA
GO:0090382phagosome maturationTAS
Component
IDNameEvidence
GO:0001669acrosomal vesicleIEA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0032010phagolysosomeTAS
GO:0043020NADPH oxidase complexTAS
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0008022protein C-terminus bindingIPI
GO:0009055electron carrier activityTAS
GO:0048365Rac GTPase bindingIEA
GeneCards NCF2
UniProt P19878
Vega OTTHUMG00000035329
MIM 608515
Ensembl ENSG00000116701
HGNC 7661
HPRD 01991

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NCF2 gene?

The NCF2 gene provides instructions for making a protein called neutrophil cytosolic factor 2 (also known as p67-phox). This protein is one part (subunit) of a group of proteins that forms an enzyme complex called NADPH oxidase, which plays an essential role in the immune system. Specifically, NADPH oxidase is primarily active in immune system cells called phagocytes. These cells catch and destroy foreign invaders such as bacteria and fungi. NADPH oxidase is also thought to regulate the activity of immune cells called neutrophils. These cells play a role in adjusting the inflammatory response to optimize healing and reduce injury to the body.

The presence of foreign invaders stimulates phagocytes and triggers the assembly of NADPH oxidase. This enzyme participates in a chemical reaction that converts oxygen to a toxic molecule called superoxide. Superoxide is used to generate several other compounds, including hydrogen peroxide (a strong disinfectant) and hypochlorous acid (the active ingredient in bleach). These highly reactive, toxic substances are known as reactive oxygen species. Phagocytes use these substances to kill foreign invaders, preventing them from reproducing in the body and causing illness.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.