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NCF2 neutrophil cytosolic factor 2 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000433 Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 1, mRNA. ORF Sequence $458.49
Peptide Services
Antibody Services
Protein Services
NM_001127651 Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 2, mRNA. ORF Sequence $458.49
Peptide Services
Antibody Services
Protein Services
NM_001190789 Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 4, mRNA. ORF Sequence $388.02
Peptide Services
Antibody Services
Protein Services
NM_001190794 Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 3, mRNA. ORF Sequence $419.34
Peptide Services
Antibody Services
Protein Services


Gene Symbol NCF2
Entrez Gene ID 4688
Full Name neutrophil cytosolic factor 2
Synonyms FLJ93058, NCF-2, NOXA2, P67-PHOX, P67PHOX
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q25

Summary This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010].
Disorder

MIM: 608515

Chronic granulomatous disease due to deficiency of NCF-2, 233710 (3)

mRNA Protein Product Sequence Price Select
NM_000433, 189083740 NP_000424, 67189970 neutrophil cytosol factor 2 isoform 1 Full Length $704.41
ORF Sequence $458.49
NM_001127651, 299829277 NP_001121123, 189083742 neutrophil cytosol factor 2 isoform 1 Full Length $654.53
ORF Sequence $458.49
NM_001190789, 299829278 NP_001177718, 299829279 neutrophil cytosol factor 2 isoform 3 Full Length $633.94
ORF Sequence $388.02
NM_001190794, 299829293 NP_001177723, 299829294 neutrophil cytosol factor 2 isoform 2 Full Length $662.65
ORF Sequence $419.34
KEGG
hsa04145Phagosome
hsa04670Leukocyte transendothelial migration
hsa04380Osteoclast differentiation
hsa05140Leishmaniasis
Pathway Interaction Database
rac1_pathwayRAC1 signaling pathway
Reactome
REACT_6900Immune System
REACT_111119Antigen processing-Cross presentation
REACT_75774Adaptive Immune System
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_116125Disease
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_121256Phagosomal maturation (early endosomal stage)
Homo sapiens (human)NCF2NP_000424.2
Pan troglodytes (chimpanzee)NCF2XP_001163353.1
Macaca mulatta (Rhesus monkey)NCF2XP_001114105.2
Canis lupus familiaris (dog)NCF2NP_001095302.1
Bos taurus (cattle)NCF2NP_776545.1
Mus musculus (house mouse)Ncf2NP_035007.1
Rattus norvegicus (Norway rat)Ncf2NP_001094454.1
Gallus gallus (chicken)NCF2XP_422288.2
Danio rerio (zebrafish)ncf2NP_001103932.1
GeneCards NCF2
PDB 2DMO, 1K4U, 1OEY, 1WM5, 1E96, 1HH8
UniProt P19878
MIM 608515
Ensembl ENSG00000116701
HGNC 7661
HPRD 01991

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
neutrophil cytosol factor 2
Names
neutrophil cytosol factor 2
NADPH oxidase activator 2
67 kDa neutrophil oxidase factor
neutrophil NADPH oxidase factor 2
chronic granulomatous disease, autosomal 2
neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)

Interactant

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