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NCF4 neutrophil cytosolic factor 4, 40kDa [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16465 NM_000631 Homo sapiens neutrophil cytosolic factor 4, 40kDa (NCF4), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18835 NM_013416 Homo sapiens neutrophil cytosolic factor 4, 40kDa (NCF4), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16465C NM_000631 Homo sapiens neutrophil cytosolic factor 4, 40kDa (NCF4), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu18835C NM_013416 Homo sapiens neutrophil cytosolic factor 4, 40kDa (NCF4), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol NCF4
Entrez Gene ID 4689
Full Name neutrophil cytosolic factor 4, 40kDa
Synonyms NCF, P40PHOX, SH3PXD4
General protein information
Preferred Names
neutrophil cytosol factor 4
Names
neutrophil cytosol factor 4
NCF-4
p40-phox
neutrophil NADPH oxidase factor 4
SH3 and PX domain-containing protein 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.1

Summary The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601488

mRNA Protein Product Sequence Price Select
NM_000631, 163644268 NP_000622, 47519798 neutrophil cytosol factor 4 isoform 1 ORF Sequence $400.00
NM_013416, 163644266 NP_038202, 163644267 neutrophil cytosol factor 4 isoform 2 ORF Sequence $400.00
KEGG
hsa04670Leukocyte transendothelial migration
hsa05140Leishmaniasis
hsa04145Phagosome
hsa04380Osteoclast differentiation
Reactome
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_111119Antigen processing-Cross presentation
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_116125Disease
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
Homo sapiens (human)NCF4NP_000622.2
Pan troglodytes (chimpanzee)NCF4XP_001159332.2
Canis lupus familiaris (dog)NCF4XP_538398.2
Bos taurus (cattle)NCF4NP_001039448.1
Mus musculus (house mouse)Ncf4NP_032703.2
Rattus norvegicus (Norway rat)Ncf4NP_001120776.1
Gallus gallus (chicken)NCF4NP_001034361.1
Danio rerio (zebrafish)ncf4NP_991274.2
Xenopus (Silurana) tropicalis (western clawed frog)ncf4NP_001025692.1
Process
IDNameEvidence
GO:0002474antigen processing and presentation of peptide antigen via MHC class ITAS
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTAS
GO:0006955immune responseTAS
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class ITAS
GO:0043085positive regulation of catalytic activityIMP
GO:0051701interaction with hostTAS
GO:0055114oxidation-reduction processTAS
GO:0090382phagosome maturationTAS
Component
IDNameEvidence
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0010008endosome membraneIDA
GO:0016020membraneIDA
GO:0032010phagolysosomeTAS
GO:0043020NADPH oxidase complexIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0016176superoxide-generating NADPH oxidase activator activityIMP
GO:0032266phosphatidylinositol-3-phosphate bindingIDA
GO:0046983protein dimerization activityTAS
GeneCards NCF4
UniProt Q15080
Vega OTTHUMG00000150548
MIM 601488
Ensembl ENSG00000100365
HGNC 7662
HPRD 03289

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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