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NCF4 neutrophil cytosolic factor 4, 40kDa [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000631 Homo sapiens neutrophil cytosolic factor 4, 40kDa (NCF4), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_013416 Homo sapiens neutrophil cytosolic factor 4, 40kDa (NCF4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol NCF4
Entrez Gene ID 4689
Full Name neutrophil cytosolic factor 4, 40kDa
Synonyms NCF, P40PHOX, SH3PXD4
General protein information
Preferred Names
neutrophil cytosol factor 4
Names
neutrophil cytosol factor 4
NCF-4
p40-phox
neutrophil NADPH oxidase factor 4
SH3 and PX domain-containing protein 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.1

Summary The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601488

mRNA Protein Product Sequence Price Select
NM_000631, 163644268 NP_000622, 47519798 neutrophil cytosol factor 4 isoform 1 ORF Sequence $400.00
NM_013416, 163644266 NP_038202, 163644267 neutrophil cytosol factor 4 isoform 2 ORF Sequence $400.00
KEGG
hsa04670Leukocyte transendothelial migration
hsa05140Leishmaniasis
hsa04145Phagosome
hsa04380Osteoclast differentiation
Reactome
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_111119Antigen processing-Cross presentation
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_116125Disease
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
Homo sapiens (human)NCF4NP_000622.2
Pan troglodytes (chimpanzee)NCF4XP_001159332.2
Canis lupus familiaris (dog)NCF4XP_538398.2
Bos taurus (cattle)NCF4NP_001039448.1
Mus musculus (house mouse)Ncf4NP_032703.2
Rattus norvegicus (Norway rat)Ncf4NP_001120776.1
Gallus gallus (chicken)NCF4NP_001034361.1
Danio rerio (zebrafish)ncf4NP_991274.2
Xenopus (Silurana) tropicalis (western clawed frog)ncf4NP_001025692.1
Process
IDNameEvidence
GO:0002474antigen processing and presentation of peptide antigen via MHC class ITAS
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTAS
GO:0006955immune responseTAS
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class ITAS
GO:0043085positive regulation of catalytic activityIMP
GO:0051701interaction with hostTAS
GO:0055114oxidation-reduction processTAS
GO:0090382phagosome maturationTAS
Component
IDNameEvidence
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0010008endosome membraneIDA
GO:0016020membraneIDA
GO:0032010phagolysosomeTAS
GO:0043020NADPH oxidase complexIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0016176superoxide-generating NADPH oxidase activator activityIMP
GO:0032266phosphatidylinositol-3-phosphate bindingIDA
GO:0046983protein dimerization activityTAS
GeneCards NCF4
UniProt Q15080
Vega OTTHUMG00000150548
MIM 601488
Ensembl ENSG00000100365
HGNC 7662
HPRD 03289

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NCF4 gene?

The NCF4 gene provides instructions for making a protein called neutrophil cytosolic factor 4 (also known as p40-phox). This protein is one part (subunit) of a group of proteins that forms an enzyme complex called NADPH oxidase, which plays an essential role in the immune system. Specifically, NADPH oxidase is primarily active in immune system cells called phagocytes. These cells catch and destroy foreign invaders such as bacteria and fungi. NADPH oxidase is also thought to regulate the activity of immune cells called neutrophils. These cells play a role in adjusting the inflammatory response to optimize healing and reduce injury to the body.

The presence of foreign invaders stimulates phagocytes and triggers the assembly of NADPH oxidase. This enzyme participates in a chemical reaction that converts oxygen to a toxic molecule called superoxide. Superoxide is used to generate several other compounds, including hydrogen peroxide (a strong disinfectant) and hypochlorous acid (the active ingredient in bleach). These highly reactive, toxic substances are known as reactive oxygen species. Phagocytes use these substances to kill foreign invaders, preventing them from reproducing in the body and causing illness.

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