NCF4 neutrophil cytosolic factor 4, 40kDa [Homo sapiens (human)]
| Gene Symbol | NCF4 |
| Entrez Gene ID | 4689 |
| Full Name | neutrophil cytosolic factor 4, 40kDa |
| Synonyms | MGC3810, NCF, P40PHOX, SH3PXD4 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
22 22q13.1 |
| Summary | The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]. |
| Disorder | MIM: 601488 |
| mRNA | NM_013416, 163644266 |
| Protein | NP_038202, 163644267 |
| Product | neutrophil cytosol factor 4 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_000631, 163644268 |
| Protein | NP_000622, 47519798 |
| Product | neutrophil cytosol factor 4 isoform 1 |
| RefSeq Status | REVIEWED |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04145 | Phagosome |
| hsa04380 | Osteoclast differentiation |
| hsa05140 | Leishmaniasis |
| Homo sapiens (human) | NCF4 | NP_000622.2 |
| Pan troglodytes (chimpanzee) | NCF4 | XP_001159332.1 |
| Canis lupus familiaris (dog) | NCF4 | XP_538398.2 |
| Bos taurus (cattle) | NCF4 | NP_001039448.1 |
| Mus musculus (house mouse) | Ncf4 | NP_032703.1 |
| Rattus norvegicus (Norway rat) | Ncf4 | XP_576306.2 |
| Gallus gallus (chicken) | NCF4 | NP_001034361.1 |
| Danio rerio (zebrafish) | ncf4 | NP_991274.1 |
| ID | Name | Evidence |
| GO:0006955 | immune response | TAS |
| GO:0007154 | cell communication | IEA |
| GO:0055114 | oxidation-reduction process | TAS |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005829 | cytosol | IDA |
| GO:0016020 | membrane | IDA |
| GO:0043020 | NADPH oxidase complex | IDA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
| GO:0035091 | phosphatidylinositol binding | IEA |
| GO:0046983 | protein dimerization activity | TAS |
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