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Sequence in raw or FASTA format:


Blast Method:


ATM ATM serine/threonine kinase [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000051 Homo sapiens ATM serine/threonine kinase (ATM), mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_005271561 PREDICTED: Homo sapiens ataxia telangiectasia mutated (ATM), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_005271562 PREDICTED: Homo sapiens ataxia telangiectasia mutated (ATM), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_005271564 PREDICTED: Homo sapiens ataxia telangiectasia mutated (ATM), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006718843 PREDICTED: Homo sapiens ataxia telangiectasia mutated (ATM), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006718844 PREDICTED: Homo sapiens ataxia telangiectasia mutated (ATM), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006718845 PREDICTED: Homo sapiens ataxia telangiectasia mutated (ATM), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $2699.00 30

*Business Day

Related Services

Gene Symbol ATM
Entrez Gene ID 472
Full Name ATM serine/threonine kinase
General protein information
Preferred Names
serine-protein kinase ATM
serine-protein kinase ATM
AT mutated
A-T mutated
TEL1, telomere maintenance 1, homolog
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010].

MIM: 607585

Ataxia-telangiectasia, 208900 (3); Lymphoma, B-cell non-Hodgkin,

mRNA Protein Product Sequence Price Select
NM_000051, 71902539 NP_000042, 71902540 serine-protein kinase ATM ORF Sequence $4500.00
XM_005271561, 578822202 XP_005271618, 578822203 serine-protein kinase ATM isoform X1 ORF Sequence $4500.00
XM_005271562, 578822204 XP_005271619, 578822205 serine-protein kinase ATM isoform X2 ORF Sequence $4500.00
XM_005271564, 578822210 XP_005271621, 578822211 serine-protein kinase ATM isoform X4 ORF Sequence $4500.00
XM_006718843, 578822206 XP_006718906, 578822207 serine-protein kinase ATM isoform X5 ORF Sequence $4500.00
XM_006718844, 578822208 XP_006718907, 578822209 serine-protein kinase ATM isoform X6 ORF Sequence $4500.00
XM_006718845, 578822212 XP_006718908, 578822213 serine-protein kinase ATM isoform X7 ORF Sequence $2500.00
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05166HTLV-I infection
hsa_M00295BRCA1-associated genome surveillance complex (BASC)
hsa05202Transcriptional misregulation in cancer
hsa04064NF-kappa B signaling pathway
hsa05206MicroRNAs in cancer
hsa04068FoxO signaling pathway
WP707DNA damage response
WP1984Integrated Breast Cancer Pathway
WP34Ovarian Infertility Genes
WP45G1 to S cell cycle control
WP179Cell cycle
WP710DNA damage response (only ATM dependent)
WP1742TP53 network
WP186Homologous recombination
WP1545miRNAs involved in DDR
WP2377Integrated Pancreatic Cancer Pathway
WP2261Signaling Pathways in Glioblastoma
WP1971Integrated Cancer pathway
WP2263Prostate Cancer
Pathway Interaction Database
p38_mkk3_6pathwayp38 MAPK signaling pathway
bard1pathwayBARD1 signaling events
telomerasepathwayRegulation of Telomerase
e2f_pathwayE2F transcription factor network
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
p53regulationpathwayp53 pathway
REACT_1538Cell Cycle Checkpoints
REACT_2254G1/S DNA Damage Checkpoints
REACT_897G2/M DNA damage checkpoint
REACT_1614Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
REACT_309Stabilization of p53
REACT_1208p53-Independent G1/S DNA damage checkpoint
REACT_2160p53-Independent DNA Damage Response
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_828G2/M Checkpoints
REACT_216DNA Repair
REACT_1587Homologous recombination repair of replication-independent double-strand breaks
REACT_204ATM mediated response to DNA double-strand break
REACT_18410Fanconi Anemia pathway
REACT_18265Regulation of the Fanconi anemia pathway
REACT_97Recruitment of repair and signaling proteins to double-strand breaks
REACT_2054Double-Strand Break Repair
REACT_1874Homologous Recombination Repair
REACT_1924ATM mediated phosphorylation of repair proteins
REACT_20549Autodegradation of the E3 ubiquitin ligase COP1
REACT_27271Meiotic recombination
REACT_115566Cell Cycle
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_169185DNA Damage/Telomere Stress Induced Senescence
REACT_200819Cellular response to heat stress
REACT_200780Regulation of HSF1-mediated heat shock response
Homo sapiens (human)ATMNP_000042.3
Pan troglodytes (chimpanzee)ATMXP_001139405.2
Macaca mulatta (Rhesus monkey)ATMXP_002799825.1
Canis lupus familiaris (dog)ATMNP_001124300.1
Bos taurus (cattle)ATMNP_001192864.1
Mus musculus (house mouse)AtmNP_031525.2
Rattus norvegicus (Norway rat)AtmNP_001100291.1
Gallus gallus (chicken)ATMNP_001155872.1
Danio rerio (zebrafish)atmXP_002664603.2
Xenopus (Silurana) tropicalis (western clawed frog)atmXP_002934974.2
GO:0000723telomere maintenanceIEA
GO:0000724double-strand break repair via homologous recombinationTAS
GO:0001666response to hypoxiaIEA
GO:0002331pre-B cell allelic exclusionISS
GO:0006281DNA repairTAS
GO:0006302double-strand break repairTAS
GO:0006468protein phosphorylationIDA
GO:0006974cellular response to DNA damage stimulusIMP
GO:0006975DNA damage induced protein phosphorylationIDA
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTAS
GO:0007050cell cycle arrestIMP
GO:0007094mitotic spindle assembly checkpointIMP
GO:0007131reciprocal meiotic recombinationTAS
GO:0007165signal transductionTAS
GO:0007420brain developmentIEA
GO:0007507heart developmentIEA
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIEA
GO:0010212response to ionizing radiationIDA
GO:0018105peptidyl-serine phosphorylationIDA
GO:0030889negative regulation of B cell proliferationIMP
GO:0035404histone-serine phosphorylationIEA
GO:0036092phosphatidylinositol-3-phosphate biosynthetic processIMP
GO:0042159lipoprotein catabolic processIEA
GO:0043065positive regulation of apoptotic processIMP
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediatorIMP
GO:0043525positive regulation of neuron apoptotic processIEA
GO:0046777protein autophosphorylationIDA
GO:0048599oocyte developmentIEA
GO:0051402neuron apoptotic processIEA
GO:0071044histone mRNA catabolic processIDA
GO:0071480cellular response to gamma radiationIDA
GO:0072434signal transduction involved in mitotic G2 DNA damage checkpointIMP
GO:0090399replicative senescenceIMP
GO:0000781chromosome, telomeric regionIDA
GO:0016023cytoplasmic membrane-bounded vesicleIEA
GO:0003677DNA bindingIEA
GO:0004674protein serine/threonine kinase activityIDA
GO:0004677DNA-dependent protein kinase activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:00163031-phosphatidylinositol-3-kinase activityIMP
GO:0032403protein complex bindingIDA
GO:0035174histone serine kinase activityIEA
GO:0046983protein dimerization activityIDA
GO:0047485protein N-terminus bindingIDA
GeneCards ATM
UniProt Q13315
Vega OTTHUMG00000166480
MIM 607585
Ensembl ENSG00000149311
HGNC 795
HPRD 06347

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ATM gene?

The ATM gene provides instructions for making a protein that is located primarily in the nucleus of cells, where it helps control the rate at which cells grow and divide. This protein also plays an important role in the normal development and activity of several body systems, including the nervous system and the immune system. Additionally, the ATM protein assists cells in recognizing damaged or broken DNA strands. DNA can be damaged by agents such as toxic chemicals or radiation. Breaks in DNA strands also occur naturally when chromosomes exchange genetic material during cell division. The ATM protein coordinates DNA repair by activating enzymes that fix the broken strands. Efficient repair of damaged DNA strands helps maintain the stability of the cell's genetic information.

Because of its central role in cell division and DNA repair, the ATM protein is of great interest in cancer research.


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