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NF2 neurofibromin 2 (merlin) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000268 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_016418 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_181825 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 12, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_181828 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_181829 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_181830 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 7, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_181831 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 13, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_181832 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_181833 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

Related Services

Gene Symbol NF2
Entrez Gene ID 4771
Full Name neurofibromin 2 (merlin)
Synonyms ACN, BANF, SCH
General protein information
Preferred Names
merlin
Names
merlin
schwannomin
schwannomerlin
neurofibromin-2
moesin-ezrin-radixin like
moesin-ezrin-radixin-like protein
moesin-ezrin-radizin-like protein
neurofibromin 2 (bilateral acoustic neuroma)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q12.2

Summary This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008].
Disorder

MIM: 607379

Neurofibromatosis, type 2, 101000 (3); Meningioma, NF2-related,

mRNA Protein Product Sequence Price Select
NM_000268, 163644284 NP_000259, 4557795 merlin isoform 1 ORF Sequence $700.00
NM_016418, 163644285 NP_057502, 32451486 merlin isoform 2 ORF Sequence $700.00
NM_181825, 163644291 NP_861546, 32967254 merlin isoform 2 ORF Sequence $700.00
NM_181828, 163644286 NP_861966, 32967260 merlin isoform 5 ORF Sequence $550.00
NM_181829, 163644287 NP_861967, 32967262 merlin isoform 6 ORF Sequence $550.00
NM_181830, 163644288 NP_861968, 32967264 merlin isoform 7 ORF Sequence $360.00
NM_181831, 163644292 NP_861969, 32967514 merlin isoform 7 ORF Sequence $360.00
NM_181832, 163644289 NP_861970, 32967266 merlin isoform 2 ORF Sequence $700.00
NM_181833, 163644290 NP_861971, 32967268 merlin isoform 8 ORF Sequence $250.00
KEGG
hsa04390Hippo signaling pathway
Pathway Interaction Database
erbb2erbb3pathwayErbB2/ErbB3 signaling events
Homo sapiens (human)NF2NP_000259.1
Macaca mulatta (Rhesus monkey)NF2XP_001106489.1
Canis lupus familiaris (dog)NF2XP_534729.2
Bos taurus (cattle)NF2XP_003587221.1
Mus musculus (house mouse)Nf2NP_035028.2
Rattus norvegicus (Norway rat)Nf2NP_037325.1
Gallus gallus (chicken)NF2NP_989828.2
Danio rerio (zebrafish)nf2aNP_001122179.1
Drosophila melanogaster (fruit fly)MerNP_523413.1
Xenopus (Silurana) tropicalis (western clawed frog)nf2NP_001072362.1
Process
IDNameEvidence
GO:0001707mesoderm formationIEA
GO:0001953negative regulation of cell-matrix adhesionTAS
GO:0006469negative regulation of protein kinase activityIEA
GO:0007398ectoderm developmentIEA
GO:0008156negative regulation of DNA replicationIMP
GO:0008285negative regulation of cell proliferationIDA
GO:0008285negative regulation of cell proliferationIMP
GO:0014010Schwann cell proliferationIMP
GO:0022408negative regulation of cell-cell adhesionIDA
GO:0030036actin cytoskeleton organizationIMP
GO:0030336negative regulation of cell migrationTAS
GO:0035330regulation of hippo signalingIMP
GO:0042475odontogenesis of dentin-containing toothIEA
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0042524negative regulation of tyrosine phosphorylation of Stat5 proteinIDA
GO:0043409negative regulation of MAPK cascadeIEA
GO:0045216cell-cell junction organizationIEA
GO:0046426negative regulation of JAK-STAT cascadeIDA
GO:0051496positive regulation of stress fiber assemblyIMP
GO:0070306lens fiber cell differentiationIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005769early endosomeIDA
GO:0005856cytoskeletonTAS
GO:0005886plasma membraneIDA
GO:0005912adherens junctionIEA
GO:0016020membraneIDA
GO:0019898extrinsic component of membraneIEA
GO:0030027lamellipodiumIEA
GO:0030864cortical actin cytoskeletonIEA
GO:0031527filopodium membraneIEA
GO:0032154cleavage furrowIEA
GO:0032587ruffle membraneIEA
GO:0048471perinuclear region of cytoplasmIDA
Function
IDNameEvidence
GO:0003779actin bindingIEA
GO:0005515protein bindingIPI
GeneCards NF2
UniProt P35240
Vega OTTHUMG00000030727
MIM 607379
Ensembl ENSG00000186575
HGNC 7773
HPRD 06980

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NF2 gene?

The NF2 gene provides instructions for the production of a protein called merlin, also known as schwannomin. This protein is made in the nervous system, particularly in specialized cells that wrap around and insulate nerves (Schwann cells).

Merlin is believed to play a role in controlling cell shape, cell movement, and communication between cells. To carry out these tasks, merlin associates with the internal framework that supports the cell (the cytoskeleton). Merlin also functions as a tumor suppressor protein, which prevents cells from growing and dividing too fast or in an uncontrolled way.

Interactant

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