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NF2 neurofibromin 2 (merlin) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000268 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_016418 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_181825 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 12, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_181828 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_181829 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_181830 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 7, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_181831 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 13, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_181832 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_181833 Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

Related Services

Gene Symbol NF2
Entrez Gene ID 4771
Full Name neurofibromin 2 (merlin)
Synonyms ACN, BANF, SCH
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q12.2

Summary This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008].
Disorder

MIM: 607379

Neurofibromatosis, type 2, 101000 (3); Meningioma, NF2-related,

mRNA Protein Product Sequence Price Select
NM_000268, 163644284 NP_000259, 4557795 merlin isoform 1 ORF Sequence $700.00
NM_016418, 163644285 NP_057502, 32451486 merlin isoform 2 ORF Sequence $700.00
NM_181825, 163644291 NP_861546, 32967254 merlin isoform 2 ORF Sequence $700.00
NM_181828, 163644286 NP_861966, 32967260 merlin isoform 5 ORF Sequence $550.00
NM_181829, 163644287 NP_861967, 32967262 merlin isoform 6 ORF Sequence $550.00
NM_181830, 163644288 NP_861968, 32967264 merlin isoform 7 ORF Sequence $360.00
NM_181831, 163644292 NP_861969, 32967514 merlin isoform 7 ORF Sequence $360.00
NM_181832, 163644289 NP_861970, 32967266 merlin isoform 2 ORF Sequence $700.00
NM_181833, 163644290 NP_861971, 32967268 merlin isoform 8 ORF Sequence $250.00
Pathway Interaction Database
erbb2erbb3pathwayErbB2/ErbB3 signaling events
Homo sapiens (human)NF2NP_000259.1
Macaca mulatta (Rhesus monkey)NF2XP_001106489.1
Canis lupus familiaris (dog)NF2XP_534729.2
Bos taurus (cattle)NF2XP_003587221.1
Mus musculus (house mouse)Nf2NP_035028.2
Rattus norvegicus (Norway rat)Nf2NP_037325.1
Gallus gallus (chicken)NF2NP_989828.2
Danio rerio (zebrafish)nf2aNP_001122179.1
Drosophila melanogaster (fruit fly)MerNP_523413.1
GeneCards NF2
PDB 3U8Z, 1H4R
UniProt P35240
MIM 607379
Ensembl ENSG00000186575
HGNC 7773
HPRD 06980

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
merlin
Names
merlin
schwannomin
schwannomerlin
neurofibromin-2
moesin-ezrin-radixin like
moesin-ezrin-radixin-like protein
moesin-ezrin-radizin-like protein
neurofibromin 2 (bilateral acoustic neuroma)

Interactant



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