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ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001256213 Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001256214 Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_152296 Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005258953 PREDICTED: Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol ATP1A3
Entrez Gene ID 478
Full Name ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms AHC2, DYT12, RDP
General protein information
Preferred Names
sodium/potassium-transporting ATPase subunit alpha-3
Names
sodium/potassium-transporting ATPase subunit alpha-3
Na+/K+ ATPase 3
sodium pump subunit alpha-3
Na(+)/K(+) ATPase alpha-3 subunit
Na(+)/K(+) ATPase alpha(III) subunit
sodium-potassium-ATPase, alpha 3 polypeptide
sodium-potassium ATPase catalytic subunit alpha-3
sodium/potassium-transporting ATPase alpha-3 chain
NP_001243142.1
NP_001243143.1
NP_689509.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.31

Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Disorder

MIM: 182350

Dystonia-12, 128235 (3)

mRNA Protein Product Sequence Price Select
NM_001256213, 371940937 NP_001243142, 371940938 sodium/potassium-transporting ATPase subunit alpha-3 isoform 2 ORF Sequence $1500.00
NM_001256214, 371940939 NP_001243143, 371940940 sodium/potassium-transporting ATPase subunit alpha-3 isoform 3 ORF Sequence $1500.00
NM_152296, 371940934 NP_689509, 22748667 sodium/potassium-transporting ATPase subunit alpha-3 isoform 1 ORF Sequence $1500.00
XM_005258953, 530416618 XP_005259010, 530416619 sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 ORF Sequence $1500.00
KEGG
hsa04260Cardiac muscle contraction
hsa04964Proximal tubule bicarbonate reclamation
hsa04973Carbohydrate digestion and absorption
hsa04960Aldosterone-regulated sodium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
hsa04978Mineral absorption
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04976Bile secretion
hsa04918Thyroid hormone synthesis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04911Insulin secretion
hsa04919Thyroid hormone signaling pathway
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP706SIDS Susceptibility Pathways
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25149Ion transport by P-type ATPases
REACT_25300Ion channel transport
Homo sapiens (human)ATP1A3NP_001243143.1
Pan troglodytes (chimpanzee)ATP1A3XP_003316427.1
Macaca mulatta (Rhesus monkey)ATP1A3XP_002801302.1
Canis lupus familiaris (dog)ATP1A3XP_005616573.1
Bos taurus (cattle)ATP1A3XP_002695120.2
Mus musculus (house mouse)Atp1a3NP_659170.1
Rattus norvegicus (Norway rat)Atp1a3NP_036638.1
Gallus gallus (chicken)ATP1A3NP_990806.1
Danio rerio (zebrafish)atp1a3aNP_571759.2
Danio rerio (zebrafish)atp1a3bNP_571760.2
Drosophila melanogaster (fruit fly)AtpalphaNP_732572.1
Caenorhabditis eleganseat-6NP_506269.1
Xenopus (Silurana) tropicalis (western clawed frog)atp1a3NP_001120366.1
Process
IDNameEvidence
GO:0006754ATP biosynthetic processIEA
GO:0006813potassium ion transportIEA
GO:0007613memoryIEA
GO:0008344adult locomotory behaviorIEA
GO:0008542visual learningIEA
GO:0034220ion transmembrane transportTAS
GO:0035235ionotropic glutamate receptor signaling pathwayIEA
GO:0035725sodium ion transmembrane transportIEA
GO:0035725sodium ion transmembrane transportIMP
GO:0042493response to drugIEA
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005783endoplasmic reticulumIDA
GO:0005794Golgi apparatusIDA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005890sodium:potassium-exchanging ATPase complexIC
GO:0016021integral component of membraneNAS
GO:0030424axonIEA
GO:0043209myelin sheathIEA
GO:0044326dendritic spine neckIEA
GO:0044327dendritic spine headIEA
GO:0045202synapseISS
Function
IDNameEvidence
GO:0005391sodium:potassium-exchanging ATPase activityIMP
GO:0005524ATP bindingNAS
GO:0031748D1 dopamine receptor bindingIEA
GO:0046872metal ion bindingIEA
GeneCards ATP1A3
UniProt Q53ES0, P13637
Vega OTTHUMG00000137384
MIM 182350
Ensembl ENSG00000105409
HGNC 801
HPRD 01666

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ATP1A3 gene?

The ATP1A3 gene provides instructions for making one part (the alpha-3 subunit) of a protein known as Na+/K+ ATPase or the sodium pump. This protein uses energy from a molecule called adenosine triphosphate (ATP) to transport charged atoms (ions) into and out of cells. Specifically, it pumps sodium ions (Na+) out of cells and potassium ions (K+) into cells.

Na+/K+ ATPases that include the alpha-3 subunit are primarily found in nerve cells (neurons) in the brain and are critical for their normal function. The movement of sodium and potassium ions helps regulate the electrical activity of these cells and plays an important role in the signaling process that controls muscle movement. The activity of Na+/K+ ATPase also helps regulate cell size (volume).

Additionally, Na+/K+ ATPase helps regulate a process called neurotransmitter reuptake. Neurotransmitters are chemicals that transmit signals from one neuron to another. After a neurotransmitter has had its effect, it must be removed quickly from the space between the neurons. The reuptake of neurotransmitters is carefully controlled to ensure that signals are sent and received accurately throughout the nervous system.

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