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ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26608 NM_001256213 Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu26791 NM_152296 Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu27445 NM_001256214 Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu52280 XM_005258953 PREDICTED: Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu26608C NM_001256213 Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant 2, mRNA. Customized vector On-demand 25 $1699.00
OHu26791C NM_152296 Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant 1, mRNA. Customized vector On-demand 25 $1699.00
OHu27445C NM_001256214 Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant 3, mRNA. Customized vector On-demand 25 $1699.00
OHu52280C XM_005258953 PREDICTED: Homo sapiens ATPase, Na+/K+ transporting, alpha 3 polypeptide (ATP1A3), transcript variant X1, mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol ATP1A3
Entrez Gene ID 478
Full Name ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms AHC2, DYT12, RDP
General protein information
Preferred Names
sodium/potassium-transporting ATPase subunit alpha-3
Names
sodium/potassium-transporting ATPase subunit alpha-3
Na+/K+ ATPase 3
sodium pump subunit alpha-3
Na(+)/K(+) ATPase alpha-3 subunit
Na(+)/K(+) ATPase alpha(III) subunit
sodium-potassium-ATPase, alpha 3 polypeptide
sodium-potassium ATPase catalytic subunit alpha-3
sodium/potassium-transporting ATPase alpha-3 chain
NP_001243142.1
NP_001243143.1
NP_689509.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.31

Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Disorder

MIM: 182350

Dystonia-12, 128235 (3)

mRNA Protein Product Sequence Price Select
NM_001256213, 371940937 NP_001243142, 371940938 sodium/potassium-transporting ATPase subunit alpha-3 isoform 2 ORF Sequence $1500.00
NM_001256214, 371940939 NP_001243143, 371940940 sodium/potassium-transporting ATPase subunit alpha-3 isoform 3 ORF Sequence $1500.00
NM_152296, 371940934 NP_689509, 22748667 sodium/potassium-transporting ATPase subunit alpha-3 isoform 1 ORF Sequence $1500.00
XM_005258953, 530416618 XP_005259010, 530416619 sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 ORF Sequence $1500.00
KEGG
hsa04260Cardiac muscle contraction
hsa04964Proximal tubule bicarbonate reclamation
hsa04973Carbohydrate digestion and absorption
hsa04960Aldosterone-regulated sodium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
hsa04978Mineral absorption
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04976Bile secretion
hsa04918Thyroid hormone synthesis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04911Insulin secretion
hsa04919Thyroid hormone signaling pathway
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP706SIDS Susceptibility Pathways
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25149Ion transport by P-type ATPases
REACT_25300Ion channel transport
Homo sapiens (human)ATP1A3NP_001243143.1
Pan troglodytes (chimpanzee)ATP1A3XP_003316427.1
Macaca mulatta (Rhesus monkey)ATP1A3XP_002801302.1
Canis lupus familiaris (dog)ATP1A3XP_005616573.1
Bos taurus (cattle)ATP1A3XP_002695120.2
Mus musculus (house mouse)Atp1a3NP_659170.1
Rattus norvegicus (Norway rat)Atp1a3NP_036638.1
Gallus gallus (chicken)ATP1A3NP_990806.1
Danio rerio (zebrafish)atp1a3aNP_571759.2
Danio rerio (zebrafish)atp1a3bNP_571760.2
Drosophila melanogaster (fruit fly)AtpalphaNP_732572.1
Caenorhabditis eleganseat-6NP_506269.1
Xenopus (Silurana) tropicalis (western clawed frog)atp1a3NP_001120366.1
Process
IDNameEvidence
GO:0006754ATP biosynthetic processIEA
GO:0006813potassium ion transportIEA
GO:0007613memoryIEA
GO:0008344adult locomotory behaviorIEA
GO:0008542visual learningIEA
GO:0034220ion transmembrane transportTAS
GO:0035235ionotropic glutamate receptor signaling pathwayIEA
GO:0035725sodium ion transmembrane transportIEA
GO:0035725sodium ion transmembrane transportIMP
GO:0042493response to drugIEA
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005783endoplasmic reticulumIDA
GO:0005794Golgi apparatusIDA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005890sodium:potassium-exchanging ATPase complexIC
GO:0016021integral component of membraneNAS
GO:0030424axonIEA
GO:0043209myelin sheathIEA
GO:0044326dendritic spine neckIEA
GO:0044327dendritic spine headIEA
GO:0045202synapseISS
Function
IDNameEvidence
GO:0005391sodium:potassium-exchanging ATPase activityIMP
GO:0005524ATP bindingNAS
GO:0031748D1 dopamine receptor bindingIEA
GO:0046872metal ion bindingIEA
GeneCards ATP1A3
UniProt Q53ES0, P13637
Vega OTTHUMG00000137384
MIM 182350
Ensembl ENSG00000105409
HGNC 801
HPRD 01666

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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