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NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_020529 Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

*Business Day

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Gene Symbol NFKBIA
Entrez Gene ID 4792
Full Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Synonyms IKBA, MAD-3, NFKBI
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q13

Summary This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011].
Disorder

MIM: 164008

Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency,

mRNA Protein Product Sequence Price Select
NM_020529, 168693660 NP_065390, 10092619 NF-kappa-B inhibitor alpha ORF Sequence $269.00
KEGG
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05162Measles
hsa04660T cell receptor signaling pathway
hsa05215Prostate cancer
hsa05222Small cell lung cancer
hsa04622RIG-I-like receptor signaling pathway
hsa05161Hepatitis B
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa05131Shigellosis
hsa05145Toxoplasmosis
hsa04623Cytosolic DNA-sensing pathway
hsa04920Adipocytokine signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04210Apoptosis
hsa05220Chronic myeloid leukemia
hsa05160Hepatitis C
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa04062Chemokine signaling pathway
hsa05134Legionellosis
hsa05140Leishmaniasis
hsa05168Herpes simplex infection
hsa04064NF-kappa B signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04662B cell receptor signaling pathway
hsa05203Viral carcinogenesis
hsa04621NOD-like receptor signaling pathway
WikiPathways
WP2374Oncostatin M Signaling Pathway
WP2324AGE/RAGE pathway
WP2256Integrated Pancreatic Cancer Pathway
WP127IL-5 Signaling Pathway
WP2203TSLP Signaling Pathway
WP254Apoptosis
WP61Delta-Notch Signaling Pathway
WP2036TWEAK Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP69TCR Signaling Pathway
WP1772Apoptosis Modulation and Signaling
WP75Toll-like receptor signaling pathway
WP2037Prolactin Signaling Pathway
WP231TNF-alpha/NF-kB Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP1433NOD pathway
WP2018RANKL/RANK Signaling Pathway
Pathway Interaction Database
nfkappabatypicalpathwayAtypical NF-kappaB pathway
aurora_a_pathwayAurora A signaling
avb3_opn_pathwayOsteopontin-mediated events
hivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
cd40_pathwayCD40/CD40L signaling
hdac_classi_pathwaySignaling events mediated by HDAC Class I
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
lysophospholipid_pathwayLPA receptor mediated events
il23pathwayIL23-mediated signaling events
ceramide_pathwayCeramide signaling pathway
bcr_5pathwayBCR signaling pathway
Reactome
REACT_11061Signalling by NGF
REACT_25281NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_13776p75 NTR receptor-mediated signalling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_6802Innate Immune System
REACT_12555Downstream TCR signaling
REACT_6809MyD88-independent cascade
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_118764DAI mediated induction of type I IFNs
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_13696NF-kB is activated and signals survival
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6890Activated TLR4 signalling
REACT_75774Adaptive Immune System
REACT_13537p75NTR signals via NF-kB
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_111102Signal Transduction
REACT_12526TCR signaling
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_6900Immune System
REACT_6966Toll Receptor Cascades
REACT_24969TRAF6 mediated NF-kB activation
REACT_118656Activation of NF-kappaB in B Cells
REACT_118563RIP-mediated NFkB activation via DAI
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
Homo sapiens (human)NFKBIANP_065390.1
Pan troglodytes (chimpanzee)NFKBIAXP_522823.2
Macaca mulatta (Rhesus monkey)NFKBIAXP_001087842.1
Canis lupus familiaris (dog)NFKBIAXP_537413.3
Bos taurus (cattle)NFKBIANP_001039333.1
Mus musculus (house mouse)NfkbiaNP_035037.2
Rattus norvegicus (Norway rat)NfkbiaNP_001099190.2
Gallus gallus (chicken)NFKBIANP_001001472.2
Drosophila melanogaster (fruit fly)cactNP_476942.1
GeneCards NFKBIA
PDB 1IKN, 1NFI
UniProt P25963
MIM 164008
Ensembl ENSG00000100906
HGNC 7797
HPRD 01235

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
NF-kappa-B inhibitor alpha
Names
NF-kappa-B inhibitor alpha
ikB-alpha
IkappaBalpha
I-kappa-B-alpha
nuclear factor of kappa light chain gene enhancer in B-cells
major histocompatibility complex enhancer-binding protein MAD3

Interactant



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