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NGF nerve growth factor (beta polypeptide) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002506 Homo sapiens nerve growth factor (beta polypeptide) (NGF), mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006710663 PREDICTED: Homo sapiens nerve growth factor (beta polypeptide) (NGF), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006710664 PREDICTED: Homo sapiens nerve growth factor (beta polypeptide) (NGF), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006710665 PREDICTED: Homo sapiens nerve growth factor (beta polypeptide) (NGF), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Gene Symbol NGF
Entrez Gene ID 4803
Full Name nerve growth factor (beta polypeptide)
Synonyms Beta-NGF, HSAN5, NGFB
General protein information
Preferred Names
beta-nerve growth factor
Names
beta-nerve growth factor
nerve growth factor, beta subunit
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p13.1

Summary This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008].
Disorder

MIM: 162030

Neuropathy, hereditary sensory and autonomic, type V, 608654 (3)

mRNA Protein Product Sequence Price Select
NM_002506, 70995318 NP_002497, 70995319 beta-nerve growth factor precursor ORF Sequence $250.00
XM_006710663, 578799178 XP_006710726, 578799179 beta-nerve growth factor isoform X1 ORF Sequence $250.00
XM_006710664, 578799180 XP_006710727, 578799181 beta-nerve growth factor isoform X2 ORF Sequence $250.00
XM_006710665, 578799182 XP_006710728, 578799183 beta-nerve growth factor isoform X3 ORF Sequence $250.00
KEGG
hsa04010MAPK signaling pathway
hsa04210Apoptosis
hsa04722Neurotrophin signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP382MAPK signaling pathway
WP706SIDS Susceptibility Pathways
WP53Id Signaling Pathway
WP2380BDNF signaling pathway
Pathway Interaction Database
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
p75ntrpathwayp75(NTR)-mediated signaling
Reactome
REACT_11061Signalling by NGF
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_11062NGF processing
REACT_11060TRKA activation by NGF
REACT_12464PI3K/AKT activation
REACT_13638NRAGE signals death through JNK
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12033Signalling to RAS
REACT_13776p75 NTR receptor-mediated signalling
REACT_11064Activation of TRKA receptors
REACT_13724NFG and proNGF binds to p75NTR
REACT_13779Axonal growth stimulation
REACT_12058Signalling to ERKs
REACT_12079PLC-gamma1 signalling
REACT_12049Signalling to STAT3
REACT_13806Ceramide signalling
REACT_13643NRIF signals cell death from the nucleus
REACT_13620p75NTR regulates axonogenesis
REACT_13695p75NTR negatively regulates cell cycle via SC1
REACT_13537p75NTR signals via NF-kB
REACT_12076Frs2-mediated activation
REACT_12002ARMS-mediated activation
REACT_12435Retrograde neurotrophin signalling
REACT_13526NADE modulates death signalling
REACT_13415p75NTR recruits signalling complexes
REACT_13696NF-kB is activated and signals survival
REACT_12077Signalling to p38 via RIT and RIN
REACT_12005Prolonged ERK activation events
REACT_111102Signal Transduction
Homo sapiens (human)NGFNP_002497.2
Pan troglodytes (chimpanzee)NGFNP_001012439.1
Macaca mulatta (Rhesus monkey)LOC711681XP_001100522.2
Canis lupus familiaris (dog)NGFNP_001181879.1
Bos taurus (cattle)NGFNP_001092832.1
Mus musculus (house mouse)NgfNP_038637.1
Rattus norvegicus (Norway rat)NgfNP_001263984.1
Gallus gallus (chicken)NGFXP_004935065.1
Xenopus (Silurana) tropicalis (western clawed frog)ngfNP_001123396.1
Process
IDNameEvidence
GO:0000186activation of MAPKK activityTAS
GO:0006954inflammatory responseIEA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS
GO:0007202activation of phospholipase C activityTAS
GO:0007264small GTPase mediated signal transductionTAS
GO:0007265Ras protein signal transductionTAS
GO:0007422peripheral nervous system developmentIEA
GO:0007613memoryIEA
GO:0008344adult locomotory behaviorIEA
GO:0008625extrinsic apoptotic signaling pathway via death domain receptorsIDA
GO:0009314response to radiationIEA
GO:0009612response to mechanical stimulusIEA
GO:0010193response to ozoneIEA
GO:0010628positive regulation of gene expressionIMP
GO:0019233sensory perception of painIEA
GO:0031954positive regulation of protein autophosphorylationIEA
GO:0032455nerve growth factor processingTAS
GO:0032496response to lipopolysaccharideIEA
GO:0035094response to nicotineIEA
GO:0042493response to drugIEA
GO:0043065positive regulation of apoptotic processTAS
GO:0043066negative regulation of apoptotic processTAS
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic processTAS
GO:0043434response to peptide hormoneIEA
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0045666positive regulation of neuron differentiationIEA
GO:0045773positive regulation of axon extensionIEA
GO:0045786negative regulation of cell cycleTAS
GO:0046928regulation of neurotransmitter secretionIEA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048812neuron projection morphogenesisIDA
GO:0050770regulation of axonogenesisTAS
GO:0050772positive regulation of axonogenesisTAS
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIEA
GO:0051384response to glucocorticoidIEA
GO:0051388positive regulation of neurotrophin TRK receptor signaling pathwayIEA
GO:0051402neuron apoptotic processIEA
GO:0051602response to electrical stimulusIEA
GO:0097190apoptotic signaling pathwayTAS
GO:0097192extrinsic apoptotic signaling pathway in absence of ligandIEA
GO:2000648positive regulation of stem cell proliferationIEA
GO:2000675negative regulation of type B pancreatic cell apoptotic processIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0005768endosomeTAS
GO:0005796Golgi lumenTAS
Function
IDNameEvidence
GO:0005057receptor signaling protein activityIEA
GO:0005163nerve growth factor receptor bindingIPI
GO:0008083growth factor activityIEA
GeneCards NGF
PDB 2IFG, 1WWW, 4EDX, 1SG1, 4EDW
UniProt P01138
Vega OTTHUMG00000011880
MIM 162030
Ensembl ENSG00000134259
HGNC 7808
HPRD 08874

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NGF gene?

The NGF gene provides instructions for making a protein called nerve growth factor beta (NGFβ). This protein is important in the development and survival of nerve cells (neurons), especially those that transmit pain, temperature, and touch sensations (sensory neurons). The NGFβ protein functions by attaching (binding) to its receptors, which initiates signaling pathways inside the cell. The NGFβ protein can bind to two different receptors, the NTRK1 receptor or the p75NTR receptor. Both receptors are found on the surface of sensory neurons and other types of neurons. The binding of the NGFβ protein to the NTRK1 receptor signals these neurons to grow and to mature and take on specialized functions (differentiate). This binding also blocks signals that initiate the process of self-destruction (apoptosis). Additionally, NGFβ signaling through NTRK1 plays a role in pain sensation. It is less clear what binding with the p75NTR receptor signals. Studies suggest that p75NTR signaling can help sensory neurons grow and differentiate but can also trigger apoptosis.

Interactant

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