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NGF nerve growth factor (beta polypeptide) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002506 Homo sapiens nerve growth factor (beta polypeptide) (NGF), mRNA. ORF Sequence $210.54
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Gene Symbol NGF
Entrez Gene ID 4803
Full Name nerve growth factor (beta polypeptide)
Synonyms Beta-NGF, HSAN5, MGC161426, MGC161428, NGFB
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p13.1

Summary This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008].
Disorder

MIM: 162030

Neuropathy, hereditary sensory and autonomic, type V, 608654 (3)

mRNA Protein Product Sequence Price Select
NM_002506, 70995318 NP_002497, 70995319 beta-nerve growth factor precursor Full Length $305.08
ORF Sequence $210.54
KEGG
hsa04151PI3K-Akt signaling pathway
hsa04010MAPK signaling pathway
hsa04210Apoptosis
hsa04722Neurotrophin signaling pathway
Pathway Interaction Database
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
p75ntrpathwayp75(NTR)-mediated signaling
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
WikiPathways
WP706SIDS Susceptibility Pathways
WP382MAPK signaling pathway
WP53Id Signaling Pathway
Reactome
REACT_13779Axonal growth stimulation
REACT_12058Signalling to ERKs
REACT_12079PLC-gamma1 signalling
REACT_13696NF-kB is activated and signals survival
REACT_13620p75NTR regulates axonogenesis
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_12076Frs2-mediated activation
REACT_13806Ceramide signalling
REACT_12464PI3K/AKT activation
REACT_13643NRIF signals cell death from the nucleus
REACT_12049Signalling to STAT3
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_13724NFG and proNGF binds to p75NTR
REACT_12033Signalling to RAS
REACT_13638NRAGE signals death through JNK
REACT_13695p75NTR negatively regulates cell cycle via SC1
REACT_11062NGF processing
REACT_13415p75NTR recruits signalling complexes
REACT_12077Signalling to p38 via RIT and RIN
REACT_11064Activation of TRKA receptors
REACT_13526NADE modulates death signalling
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_13537p75NTR signals via NF-kB
REACT_11060TRKA activation by NGF
REACT_12005Prolonged ERK activation events
REACT_12002ARMS-mediated activation
REACT_12435Retrograde neurotrophin signalling
REACT_111102Signal Transduction
Homo sapiens (human)NGFNP_002497.2
Pan troglodytes (chimpanzee)NGFNP_001012439.1
Macaca mulatta (Rhesus monkey)LOC711681XP_001100522.2
Canis lupus familiaris (dog)NGFNP_001181879.1
Bos taurus (cattle)NGFNP_001092832.1
Mus musculus (house mouse)NgfNP_038637.1
Rattus norvegicus (Norway rat)NgfXP_227525.4
Gallus gallus (chicken)NGFXP_418016.3
GeneCards NGF
PDB 2IFG, 1WWW, 1SG1
UniProt P01138
MIM 162030
Ensembl ENSG00000134259
HGNC 7808
HPRD 08874

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
beta-nerve growth factor
Names
beta-nerve growth factor
nerve growth factor, beta subunit

Interactant

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