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ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001677 Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10

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Gene Symbol ATP1B1
Entrez Gene ID 481
Full Name ATPase, Na+/K+ transporting, beta 1 polypeptide
Synonyms ATP1B, MGC1798
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q24

Summary The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010].
Disorder

MIM: 182330

[Blood pressure regulation QTL], 145500 (2)

mRNA Protein Product Sequence Price Select
NM_001677, 49574487 NP_001668, 4502277 sodium/potassium-transporting ATPase subunit beta-1 ORF Sequence $199.00
KEGG
hsa04971Gastric acid secretion
hsa04973Carbohydrate digestion and absorption
hsa04260Cardiac muscle contraction
hsa04964Proximal tubule bicarbonate reclamation
hsa04978Mineral absorption
hsa04976Bile secretion
hsa04960Aldosterone-regulated sodium reabsorption
hsa04974Protein digestion and absorption
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04970Salivary secretion
hsa04972Pancreatic secretion
WikiPathways
WP536Calcium Regulation in the Cardiac Cell
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25300Ion channel transport
REACT_604Hemostasis
REACT_25149Ion transport by P-type ATPases
REACT_12051Cell surface interactions at the vascular wall
REACT_12560Basigin interactions
Homo sapiens (human)ATP1B1NP_001668.1
Pan troglodytes (chimpanzee)ATP1B1NP_001092025.1
Macaca mulatta (Rhesus monkey)ATP1B1XP_001093541.1
Canis lupus familiaris (dog)ATP1B1NP_001003283.1
Bos taurus (cattle)ATP1B1NP_001030411.1
Mus musculus (house mouse)Atp1b1NP_033851.1
Rattus norvegicus (Norway rat)Atp1b1NP_037245.2
Gallus gallus (chicken)ATP1B1NP_990851.1
Danio rerio (zebrafish)atp1b1bNP_571746.1
Danio rerio (zebrafish)atp1b1aNP_571743.3
Drosophila melanogaster (fruit fly)nrv1NP_477167.1
GeneCards ATP1B1
UniProt A3KLL5, P05026
MIM 182330
Ensembl ENSG00000143153
HGNC 804
HPRD 01663

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-1
Names
sodium/potassium-transporting ATPase subunit beta-1
adenosinetriphosphatase
sodium pump subunit beta-1
Na, K-ATPase beta-1 polypeptide
Beta 1-subunit of Na(+),K(+)-ATPase
sodium/potassium-dependent ATPase beta-1 subunit
sodium/potassium-transporting ATPase beta-1 chain
sodium-potassium ATPase subunit beta 1 (non-catalytic)

Interactant



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