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ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18298 NM_001677 Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu18298C NM_001677 Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol ATP1B1
Entrez Gene ID 481
Full Name ATPase, Na+/K+ transporting, beta 1 polypeptide
Synonyms ATP1B
General protein information
Preferred Names
sodium/potassium-transporting ATPase subunit beta-1
Names
sodium/potassium-transporting ATPase subunit beta-1
adenosinetriphosphatase
sodium pump subunit beta-1
Na, K-ATPase beta-1 polypeptide
Beta 1-subunit of Na(+),K(+)-ATPase
sodium/potassium-dependent ATPase beta-1 subunit
sodium/potassium-transporting ATPase beta-1 chain
sodium-potassium ATPase subunit beta 1 (non-catalytic)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q24

Summary The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010].
Disorder

MIM: 182330

[Blood pressure regulation QTL], 145500 (2)

mRNA Protein Product Sequence Price Select
NM_001677, 49574487 NP_001668, 4502277 sodium/potassium-transporting ATPase subunit beta-1 ORF Sequence $199.00
KEGG
hsa04260Cardiac muscle contraction
hsa04964Proximal tubule bicarbonate reclamation
hsa04973Carbohydrate digestion and absorption
hsa04960Aldosterone-regulated sodium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
hsa04978Mineral absorption
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04976Bile secretion
hsa04918Thyroid hormone synthesis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04911Insulin secretion
hsa04919Thyroid hormone signaling pathway
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP536Calcium Regulation in the Cardiac Cell
Reactome
REACT_604Hemostasis
REACT_12051Cell surface interactions at the vascular wall
REACT_12560Basigin interactions
REACT_15518Transmembrane transport of small molecules
REACT_25149Ion transport by P-type ATPases
REACT_25300Ion channel transport
Homo sapiens (human)ATP1B1NP_001668.1
Pan troglodytes (chimpanzee)ATP1B1NP_001092025.1
Macaca mulatta (Rhesus monkey)ATP1B1XP_001093541.1
Canis lupus familiaris (dog)ATP1B1NP_001003283.1
Bos taurus (cattle)ATP1B1NP_001030411.1
Mus musculus (house mouse)Atp1b1NP_033851.1
Rattus norvegicus (Norway rat)Atp1b1NP_037245.2
Gallus gallus (chicken)ATP1B1NP_990851.1
Danio rerio (zebrafish)atp1b1bNP_571746.1
Danio rerio (zebrafish)atp1b1aNP_571743.3
Drosophila melanogaster (fruit fly)nrv3NP_001260675.1
Xenopus (Silurana) tropicalis (western clawed frog)atp1b1NP_001016488.1
Process
IDNameEvidence
GO:0001666response to hypoxiaIEA
GO:0006810transportTAS
GO:0006813potassium ion transportIEA
GO:0007155cell adhesionIEA
GO:0007596blood coagulationTAS
GO:0034220ion transmembrane transportTAS
GO:0035725sodium ion transmembrane transportIEA
GO:0035725sodium ion transmembrane transportTAS
GO:0050900leukocyte migrationTAS
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005890sodium:potassium-exchanging ATPase complexIEA
GO:0005901caveolaIEA
GO:0016323basolateral plasma membraneIEA
GO:0016324apical plasma membraneIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005391sodium:potassium-exchanging ATPase activityIEA
GO:0005515protein bindingIPI
GO:0023026MHC class II protein complex bindingIDA
GeneCards ATP1B1
UniProt A3KLL5, P05026
Vega OTTHUMG00000034590
MIM 182330
Ensembl ENSG00000143153
HGNC 804
HPRD 01663

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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