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NOS1 nitric oxide synthase 1 (neuronal) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000620 Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant 1, mRNA. ORF Sequence $1506.75
Peptide Services
Antibody Services
Protein Services
NM_001204213 Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant 3, mRNA. ORF Sequence $1153.95
Peptide Services
Antibody Services
Protein Services
NM_001204214 Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant 4, mRNA. ORF Sequence $1153.95
Peptide Services
Antibody Services
Protein Services
NM_001204218 Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant 2, mRNA. ORF Sequence $1542.45
Peptide Services
Antibody Services
Protein Services


Gene Symbol NOS1
Entrez Gene ID 4842
Full Name nitric oxide synthase 1 (neuronal)
Synonyms IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.2-q24.31

Summary The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011].
Disorder

MIM: 163731

mRNA Protein Product Sequence Price Select
NM_000620, 323635432 NP_000611, 10835173 nitric oxide synthase, brain isoform 1 Full Length $0.00
ORF Sequence $1506.75
NM_001204213, 323635430 NP_001191142, 323635431 nitric oxide synthase, brain isoform 3 Full Length $0.00
ORF Sequence $1153.95
NM_001204214, 323635433 NP_001191143, 323635434 nitric oxide synthase, brain isoform 3 Full Length $0.00
ORF Sequence $1153.95
NM_001204218, 323635435 NP_001191147, 323635436 nitric oxide synthase, brain isoform 2 Full Length $0.00
ORF Sequence $1542.45
KEGG
hsa04730Long-term depression
hsa04020Calcium signaling pathway
hsa04713Circadian entrainment
hsa04970Salivary secretion
hsa05010Alzheimer's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa00330Arginine and proline metabolism
hsa04145Phagosome
WikiPathways
WP289Myometrial Relaxation and Contraction Pathways
WP727Monoamine Transport
WP2059Alzheimers Disease
BIOCYC
HUMAN_PWY-4983citrulline-nitric oxide cycle
META_PWY-5004superpathway of citrulline metabolism
HUMAN_PWY-5004superpathway of citrulline metabolism
META_PWY-4983citrulline-nitric oxide cycle
Reactome
REACT_116125Disease
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_604Hemostasis
REACT_23876Platelet homeostasis
Homo sapiens (human)NOS1NP_000611.1
Pan troglodytes (chimpanzee)NOS1XP_003314004.2
Macaca mulatta (Rhesus monkey)NOS1XP_001083352.2
Canis lupus familiaris (dog)NOS1NP_001182074.1
Bos taurus (cattle)NOS1XP_002694631.2
Mus musculus (house mouse)Nos1NP_032738.1
Rattus norvegicus (Norway rat)Nos1NP_434686.1
Gallus gallus (chicken)NOS1XP_425296.2
Danio rerio (zebrafish)nos1NP_571735.1
Drosophila melanogaster (fruit fly)NosNP_523541.2
GeneCards NOS1
UniProt B3VK56, B4DG68, A0PJJ7, P29475
MIM 163731
Ensembl ENSG00000089250
HGNC 7872
HPRD 01226

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
nitric oxide synthase, brain
Names
nitric oxide synthase, brain
NOS type I
neuronal NOS
constitutive NOS
peptidyl-cysteine S-nitrosylase NOS1
NP_000611.1
NP_001191142.1
NP_001191143.1
NP_001191147.1

Interactant

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