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NOS1 nitric oxide synthase 1 (neuronal) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000620 Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001204213 Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001204214 Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001204218 Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719426 PREDICTED: Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719427 PREDICTED: Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006719428 PREDICTED: Homo sapiens nitric oxide synthase 1 (neuronal) (NOS1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol NOS1
Entrez Gene ID 4842
Full Name nitric oxide synthase 1 (neuronal)
Synonyms IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
General protein information
Preferred Names
nitric oxide synthase, brain
Names
nitric oxide synthase, brain
NOS type I
neuronal NOS
constitutive NOS
peptidyl-cysteine S-nitrosylase NOS1
NP_000611.1
NP_001191142.1
NP_001191143.1
NP_001191147.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.22

Summary The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011].
Disorder

MIM: 163731

mRNA Protein Product Sequence Price Select
NM_000620, 323635432 NP_000611, 10835173 nitric oxide synthase, brain isoform 1 ORF Sequence $1500.00
NM_001204213, 323635430 NP_001191142, 323635431 nitric oxide synthase, brain isoform 3 ORF Sequence $1500.00
NM_001204214, 323635433 NP_001191143, 323635434 nitric oxide synthase, brain isoform 3 ORF Sequence $1500.00
NM_001204218, 323635435 NP_001191147, 323635436 nitric oxide synthase, brain isoform 2 ORF Sequence $1500.00
XM_006719426, 578823799 XP_006719489, 578823800 nitric oxide synthase, brain isoform X1 ORF Sequence $1500.00
XM_006719427, 578823801 XP_006719490, 578823802 nitric oxide synthase, brain isoform X2 ORF Sequence $1500.00
XM_006719428, 578823803 XP_006719491, 578823804 nitric oxide synthase, brain isoform X3 ORF Sequence $1500.00
KEGG
hsa00330Arginine and proline metabolism
hsa04020Calcium signaling pathway
hsa04730Long-term depression
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05010Alzheimer's disease
hsa04970Salivary secretion
hsa04145Phagosome
hsa04713Circadian entrainment
WikiPathways
WP289Myometrial Relaxation and Contraction Pathways
WP727Monoamine Transport
WP2059Alzheimers Disease
WP2431Spinal Cord Injury
WP1995Effects of nitric oxide
WP2447Amyotrophic lateral sclerosis (ALS)
WP1455Serotonin Transporter Activity
BIOCYC
META_PWY-4983citrulline-nitric oxide cycle
HUMAN_PWY-5004superpathway of citrulline metabolism
HUMAN_PWY-4983citrulline-nitric oxide cycle
Reactome
REACT_604Hemostasis
REACT_23876Platelet homeostasis
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_116125Disease
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
Homo sapiens (human)NOS1NP_000611.1
Pan troglodytes (chimpanzee)NOS1XP_003314004.2
Macaca mulatta (Rhesus monkey)NOS1XP_001083352.2
Canis lupus familiaris (dog)NOS1NP_001182074.1
Bos taurus (cattle)NOS1XP_002694631.3
Mus musculus (house mouse)Nos1NP_032738.1
Rattus norvegicus (Norway rat)Nos1NP_434686.1
Gallus gallus (chicken)NOS1XP_004934537.1
Danio rerio (zebrafish)nos1NP_571735.1
Drosophila melanogaster (fruit fly)NosNP_523541.2
Xenopus (Silurana) tropicalis (western clawed frog)nos1XP_004910558.1
Process
IDNameEvidence
GO:0001666response to hypoxiaIEP
GO:0006527arginine catabolic processIC
GO:0006809nitric oxide biosynthetic processIBA
GO:0006809nitric oxide biosynthetic processISS
GO:0006941striated muscle contractionIEA
GO:0007263nitric oxide mediated signal transductionIBA
GO:0007520myoblast fusionTAS
GO:0007596blood coagulationTAS
GO:0009408response to heatIDA
GO:0010523negative regulation of calcium ion transport into cytosolTAS
GO:0018119peptidyl-cysteine S-nitrosylationISS
GO:0031284positive regulation of guanylate cyclase activityIBA
GO:0033555multicellular organismal response to stressIMP
GO:0035066positive regulation of histone acetylationIEA
GO:0042136neurotransmitter biosynthetic processTAS
GO:0042738exogenous drug catabolic processIEA
GO:0043267negative regulation of potassium ion transportIEA
GO:0045776negative regulation of blood pressureIBA
GO:0045909positive regulation of vasodilationIDA
GO:0045909positive regulation of vasodilationIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0051346negative regulation of hydrolase activityIEA
GO:0051612negative regulation of serotonin uptakeIEA
GO:0051701interaction with hostTAS
GO:0055114oxidation-reduction processIEA
GO:0055117regulation of cardiac muscle contractionTAS
GO:0071363cellular response to growth factor stimulusIEA
GO:0090382phagosome maturationTAS
GO:1902307positive regulation of sodium ion transmembrane transportISS
Component
IDNameEvidence
GO:0001917photoreceptor inner segmentISS
GO:0005737cytoplasmTAS
GO:0005829cytosolTAS
GO:0005856cytoskeletonISS
GO:0016529sarcoplasmic reticulumIDA
GO:0042383sarcolemmaIDA
GO:0043197dendritic spineIEA
GO:0043234protein complexISS
GO:0045202synapseIEA
GO:0048471perinuclear region of cytoplasmISS
Function
IDNameEvidence
GO:0003958NADPH-hemoprotein reductase activityIBA
GO:0004517nitric-oxide synthase activityIBA
GO:0004517nitric-oxide synthase activityISS
GO:0005506iron ion bindingIEA
GO:0005515protein bindingIPI
GO:0005516calmodulin bindingIEA
GO:0010181FMN bindingISS
GO:0016491oxidoreductase activityIBA
GO:0017080sodium channel regulator activityISS
GO:0020037heme bindingISS
GO:0034617tetrahydrobiopterin bindingNAS
GO:0034618arginine bindingTAS
GO:0044325ion channel bindingISS
GO:0046870cadmium ion bindingISS
GO:0050660flavin adenine dinucleotide bindingISS
GO:0050661NADP bindingISS
GO:0097110scaffold protein bindingISS
GeneCards NOS1
UniProt B3VK56, B4DG68, A0PJJ7, P29475
Vega OTTHUMG00000137376
MIM 163731
Ensembl ENSG00000089250
HGNC 7872
HPRD 01226

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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